You are currently viewing a new version of our website. To view the old version click .

Diseases, Volume 13, Issue 1

January 2025 - 24 articles

Cover Story: Acute myeloid leukemia (AML) is the most common form of leukemia in adults, yet survival rates remain low. Additionally, patients with AML often experience relapse and develop resistance to chemotherapy, underscoring the urgent need for new therapeutic strategies. Venetoclax, a BH3 mimetic, was recently approved for AML treatment in combination with azacitidine or cytarabine. However, these regimens still leave room for improvement. To enhance venetoclax’s therapeutic efficacy, researchers are exploring combination drug partners. Valproic acid, a long-established medication primarily used to treat epilepsy, has been found to be a promising candidate. Valproic acid can enhance the anti-AML activity of venetoclax. This approach exemplifies how drug combinations can unlock the previously untapped potential of existing medications. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (24)

  • Review
  • Open Access
17 Citations
8,485 Views
25 Pages

Integrating AI into Cancer Immunotherapy—A Narrative Review of Current Applications and Future Directions

  • David B. Olawade,
  • Aanuoluwapo Clement David-Olawade,
  • Temitope Adereni,
  • Eghosasere Egbon,
  • Jennifer Teke and
  • Stergios Boussios

20 January 2025

Background: Cancer remains a leading cause of morbidity and mortality worldwide. Traditional treatments like chemotherapy and radiation often result in significant side effects and varied patient outcomes. Immunotherapy has emerged as a promising alt...

  • Article
  • Open Access
1 Citations
1,486 Views
13 Pages

Prevalence of Respiratory Syncytial Virus Infection in Hospitalized COPD Patients in Spain Between 2018–2022

  • Rosa María Gómez-García,
  • Javier De-Miguel-Díez,
  • Ana López-de-Andrés,
  • Valentín Hernández-Barrera,
  • Ana Jimenez-Sierra,
  • Natividad Cuadrado-Corrales,
  • José J. Zamorano-León,
  • David Carabantes-Alarcón,
  • Andrés Bodas-Pinedo and
  • Rodrigo Jiménez-García

20 January 2025

Background: Respiratory syncytial virus (RSV) infection is a common cause of hospital admission. The association between chronic obstructive pulmonary disease (COPD) exacerbation and RSV infection is not well studied. Objective: To analyze the hospit...

  • Review
  • Open Access
8 Citations
4,477 Views
15 Pages

Resistance to Radiotherapy in Cancer

  • Almaz A. Akhunzianov,
  • Elvira V. Rozhina,
  • Yuliya V. Filina,
  • Albert A. Rizvanov and
  • Regina R. Miftakhova

17 January 2025

Radiation therapy or radiotherapy is a medical treatment that uses high doses of ionizing radiation to eliminate cancer cells and shrink tumors. It works by targeting the DNA within the tumor cells restricting their proliferation. Radiotherapy has be...

  • Review
  • Open Access
2 Citations
1,420 Views
15 Pages

Posterior Urethral Valves and Fertility: Insight on Paternity Rates and Seminal Parameters

  • Marcello Della Corte,
  • Simona Gerocarni Nappo,
  • Antonio Aversa,
  • Sandro La Vignera,
  • Francesco Porpiglia,
  • Cristian Fiori and
  • Nicola Mondaini

17 January 2025

Background: Posterior urethral valves (PUVs) represent the most common cause of male congenital lower urinary tract obstruction, often responsible for renal dysplasia and chronic renal failure. Despite recent improvements in patients’ outcomes...

  • Case Report
  • Open Access
2,123 Views
14 Pages

Hypercalcemia Following Adrenalectomy for Cushing Syndrome in a Patient with Post-Surgical Hypoparathyroidism

  • Pietro Locantore,
  • Alessandro Oliva,
  • Gianluca Cera,
  • Rosa Maria Paragliola,
  • Roberto Novizio,
  • Caterina Policola,
  • Andrea Corsello and
  • Alfredo Pontecorvi

17 January 2025

Background: Hypercalcemia is a frequently encountered laboratory finding in endocrinology, warranting accurate clinical and laboratory evaluation to identify its cause. While primary hyperparathyroidism and malignancies represent the most common caus...

  • Review
  • Open Access
1 Citations
3,515 Views
20 Pages

Elucidating the Role of the T Cell Receptor Repertoire in Myelodysplastic Neoplasms and Acute Myeloid Leukemia

  • Georgios Petros Barakos,
  • Vasileios Georgoulis,
  • Epameinondas Koumpis and
  • Eleftheria Hatzimichael

17 January 2025

T cells, as integral components of the adaptive immune system, recognize diverse antigens through unique T cell receptors (TCRs). To achieve this, during T cell maturation, the thymus generates a wide repertoire of TCRs. This is essential for underst...

  • Article
  • Open Access
7 Citations
2,776 Views
24 Pages

The Relationship Between Cervicovaginal Infection, Human Papillomavirus Infection and Cervical Intraepithelial Neoplasia in Romanian Women

  • Anca Daniela Brăila,
  • Cristian-Viorel Poalelungi,
  • Cristina-Crenguţa Albu,
  • Constantin Marian Damian,
  • Laurențiu Mihai Dȋră,
  • Andreea-Mariana Bănățeanu and
  • Claudia Florina Bogdan-Andreescu

16 January 2025

Cervical intraepithelial neoplasia (CIN) is a premalignant cervical condition closely linked to persistent high-risk HPV infection, a major risk factor for cervical cancer. This study aims to investigate the relationship between cervicovaginal infect...

  • Article
  • Open Access
1,633 Views
9 Pages

16 January 2025

Background/Objective: Neurotoxic soluble amyloid-β (Aβ) oligomers are key drivers of Alzheimer’s pathology, with evidence suggesting that early targeting of these soluble forms may slow disease progression. Traditional intravenous (IV...

  • Article
  • Open Access
4 Citations
2,045 Views
12 Pages

Impact of Preoperative and Intraoperative Factors on Postoperative Outcomes in Patients with Colorectal Cancer: A 10-Year Retrospective Study

  • Lucian Flavius Herlo,
  • Ioana Golu,
  • Alexandra Herlo,
  • Claudia Raluca Balasa Virzob,
  • Ionescu Alin,
  • Stela Iurciuc,
  • Ionut Eduard Iordache,
  • Luana Alexandrescu,
  • Doina Ecaterina Tofolean and
  • Raluca Dumache

15 January 2025

Background and Objectives: Colorectal cancer is a major contributor to global cancer morbidity and mortality. Surgical resection remains the cornerstone of treatment, but postoperative complications can significantly affect patient outcomes. Identify...

  • Article
  • Open Access
2 Citations
2,472 Views
20 Pages

The Development and Initial Validation of the REST Questionnaire: A Multidimensional Tool for Assessing Fatigue in Individuals with and Without a History of Cancer

  • Giuseppe Di Lorenzo,
  • Carlo Buonerba,
  • Raffaele Baio,
  • Eleonora Monteleone,
  • Francesco Passaro,
  • Antonio Tufano,
  • Vittorino Montanaro,
  • Vittorio Riccio,
  • Ilaria Gallo and
  • Francesca Cappuccio
  • + 8 authors

15 January 2025

Background: Fatigue is a prevalent and complex condition with significant impacts on well-being. Existing fatigue assessments often lack comprehensiveness or practicality for general population studies. Methods: This study validated the REST Question...

of 3

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Diseases - ISSN 2079-9721