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Diseases, Volume 12, Issue 9

September 2024 - 32 articles

Cover Story: Obesity is a chronic disease known to be associated with several medical and psychosocial comorbidities, as well as adverse alterations in terms of body composition. Currently, different strategies are available and used for the management of obesity; one of these is the anti-obesity drugs strategy. This strategy is in continuous evolvement and advancement, determining a new era of obesity treatment. In particular, Tirzepatide a new drug that has been recently developed, showed a high effectiveness in terms of weight loss and was also shown to have beneficial effects in terms of obesity comorbidities that go beyond weight loss, such as improvements in type 2 diabetes and cardiovascular diseases. However, despite this fact, little is known about the effect of this drug on body composition compartments during weight loss in people with obesity. View this paper
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Articles (32)

  • Article
  • Open Access
7 Citations
2,747 Views
19 Pages

A 3D Bio-Printed-Based Model for Pancreatic Ductal Adenocarcinoma

  • Claire Godier,
  • Zakaria Baka,
  • Laureline Lamy,
  • Varvara Gribova,
  • Philippe Marchal,
  • Philippe Lavalle,
  • Eric Gaffet,
  • Lina Bezdetnaya and
  • Halima Alem

10 September 2024

Pancreatic ductal adenocarcinoma (PDAC) is a disease with a very poor prognosis, characterized by incidence rates very close to death rates. Despite the efforts of the scientific community, preclinical models that faithfully recreate the PDAC tumor m...

  • Systematic Review
  • Open Access
9 Citations
9,862 Views
35 Pages

Medication-Related Osteonecrosis of the Jaw: A Systematic Review of Case Reports and Case Series

  • Filipa Frutuoso,
  • Filipe Freitas,
  • Miguel Vilares,
  • Helena Francisco,
  • Duarte Marques,
  • João Caramês and
  • André Moreira

9 September 2024

Medication-related osteonecrosis of the jaw (MRONJ) is a rare condition, typically seen in patients receiving antiresorptive or antiangiogenic drugs. This study aims to synthesize reports and case series of MRONJ regarding sociodemographic and clinic...

  • Systematic Review
  • Open Access
15 Citations
18,617 Views
16 Pages

The Effect of Tirzepatide on Body Composition in People with Overweight and Obesity: A Systematic Review of Randomized, Controlled Studies

  • Vincenzo Rochira,
  • Carla Greco,
  • Stefano Boni,
  • Francesco Costantino,
  • Leonardo Dalla Valentina,
  • Eleonora Zanni,
  • Leila Itani and
  • Marwan El Ghoch

5 September 2024

Tirzepatide (TZP) is a new anti-obesity drug, and little is currently known about its effect on body composition (BC) in people with overweight or obesity. The aim of this study is to conduct a systematic review on the impact of TZP on BC compartment...

  • Systematic Review
  • Open Access
9 Citations
5,137 Views
33 Pages

Uptake and Effectiveness of Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine during Pregnancy in Africa: A Scoping Review

  • Gifty Osei Berchie,
  • Patience Fakornam Doe,
  • Theodora Dedo Azu,
  • Joyce Agyeiwaa,
  • Gifty Owusu,
  • Christian Makafui Boso,
  • Naomi Kyeremaa Yeboa,
  • Dorcas Frempomaa Agyare,
  • Irene Korkoi Aboh and
  • Bernard Nabe
  • + 9 authors

4 September 2024

Malaria poses a significant threat to pregnant women in sub-Saharan Africa, necessitating effective interventions like the intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP). However, challenges persist...

  • Review
  • Open Access
24 Citations
24,159 Views
24 Pages

Tuberculosis Diagnosis: Current, Ongoing, and Future Approaches

  • Guilherme Bartolomeu-Gonçalves,
  • Joyce Marinho de Souza,
  • Bruna Terci Fernandes,
  • Laís Fernanda Almeida Spoladori,
  • Guilherme Ferreira Correia,
  • Isabela Madeira de Castro,
  • Paulo Henrique Guilherme Borges,
  • Gislaine Silva-Rodrigues,
  • Eliandro Reis Tavares and
  • Lucy Megumi Yamauchi
  • + 3 authors

3 September 2024

Tuberculosis (TB) remains an impactful infectious disease, leading to millions of deaths every year. Mycobacterium tuberculosis causes the formation of granulomas, which will determine, through the host–pathogen relationship, if the infection w...

  • Systematic Review
  • Open Access
3 Citations
8,475 Views
16 Pages

The Effect of COVID-19 and COVID-19 Vaccination on Assisted Human Reproduction Outcomes: A Systematic Review and Meta-Analysis

  • Andrea Milostić-Srb,
  • Nika Srb,
  • Jasminka Talapko,
  • Tomislav Meštrović,
  • Tihomil Žiger,
  • Stana Pačarić,
  • Rajko Fureš,
  • Vedrana Makarović and
  • Ivana Škrlec

3 September 2024

The most discussed infectious disease is coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Many research endeavors have focused on the effects of the virus on reproductive organs, a...

  • Article
  • Open Access
2 Citations
3,083 Views
12 Pages

Survival Trends for Uterine Sarcomas from a Tertiary Center: The Oxford Experience

  • Aakriti Aggarwal,
  • Federico Ferrari,
  • Andreas Zouridis,
  • Sean Kehoe,
  • Sarah Pratap,
  • Elisa Gozzini and
  • Hooman Soleymani Majd

2 September 2024

Uterine sarcomas are rare and aggressive gynecological malignancies. We evaluated the epidemiology, treatment outcomes and survival rates in uterine sarcoma patients managed in our institute. The medical records of women with histology proven uterine...

  • Article
  • Open Access
2 Citations
1,646 Views
11 Pages

Characteristics of Patients with Persistent COVID-19 Symptoms and Unscheduled Return Visits to a Centre for COVID-19 Evaluation

  • Silvia Nica,
  • Remus Iulian Nica,
  • Horia Alexandru Nica,
  • Daniela Miricescu,
  • Mohamed Abuzied Ali Khattab Abdelfatah,
  • Oana Maria Schiopu,
  • Ioan Cristian Nedelcu,
  • Danut Gheorghe Cimponeriu,
  • Constantin Stefani and
  • Iulia-Ioana Stanescu-Spinu
  • + 1 author

30 August 2024

Background: This retrospective study aimed to evaluate the characteristics of patients with long COVID syndrome. Methods: This study included 457 adults who had at least one persistent symptom after COVID-19 infection. Results: The median time interv...

  • Article
  • Open Access
2,252 Views
15 Pages

Utility of Extraction-Free SARS-CoV-2 Detection by RT–qPCR for COVID-19 Testing in a Resource-Limited Setting

  • Akua K. Yalley,
  • Selasie Ahiatrogah,
  • Iddrisu I. Moro,
  • Peter Gmagna,
  • Isaac K. Yankson,
  • Anna A. Kafintu-Kwashie and
  • Nicholas I. Nii-Trebi

26 August 2024

The COVID-19 epidemic had a profound impact on global health and the economy and Ghana was no exception to its far-reaching consequences. Regarding detection of the causative agent—the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2...

  • Review
  • Open Access
7 Citations
9,279 Views
19 Pages

Current Gallstone Treatment Methods, State of the Art

  • Xiangtian Li,
  • Jun Ouyang and
  • Jingxing Dai

26 August 2024

This study aims to provide valuable references for clinicians in selecting appropriate surgical methods for biliary tract stones based on patient conditions. In this paper, the advantages and disadvantages of various minimally invasive cholelithiasis...

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Diseases - ISSN 2079-9721