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Diseases, Volume 12, Issue 9

September 2024 - 32 articles

Cover Story: Obesity is a chronic disease known to be associated with several medical and psychosocial comorbidities, as well as adverse alterations in terms of body composition. Currently, different strategies are available and used for the management of obesity; one of these is the anti-obesity drugs strategy. This strategy is in continuous evolvement and advancement, determining a new era of obesity treatment. In particular, Tirzepatide a new drug that has been recently developed, showed a high effectiveness in terms of weight loss and was also shown to have beneficial effects in terms of obesity comorbidities that go beyond weight loss, such as improvements in type 2 diabetes and cardiovascular diseases. However, despite this fact, little is known about the effect of this drug on body composition compartments during weight loss in people with obesity. View this paper

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Articles (32)

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Case Report

1 Citations

1,561 Views

9 Pages

Malignant Epithelioid Neoplasm versus Dedifferentiated Malignant Melanoma: A Case Report

Angela Rosenberg,
Chapman Wei,
Yisroel Grabie,
Stephanie Chain,
Sakura Thapa and
Gita Vatandoust

Diseases2024, 12(9), 196;https://doi.org/10.3390/diseases12090196

24 August 2024

The metastasis of poorly differentiated epithelioid carcinoma to the axillary node is uncommon. This tumor has heterogeneous expression and is challenging to diagnose with certainty. Often, it necessitates immunoperoxidase staining to ascertain the t...

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Review

14 Citations

5,055 Views

12 Pages

Ceramides—Emerging Biomarkers of Lipotoxicity in Obesity, Diabetes, Cardiovascular Diseases, and Inflammation

Ginka Delcheva,
Katya Stefanova and
Teodora Stankova

Diseases2024, 12(9), 195;https://doi.org/10.3390/diseases12090195

23 August 2024

Abnormalities in lipid homeostasis have been associated with many human diseases, and the interrelation between lipotoxicity and cellular dysfunction has received significant attention in the past two decades. Ceramides (Cers) are bioactive lipid mol...

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