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Biology, Volume 9, Issue 2

February 2020 - 18 articles

Cover Story: Diatoms colonize diverse environments including polar regions. Recent genomic data has provided initial insights into some peculiar metabolic features that allow them to strive in harsh environments. Lavoie et al. built the first genome-scale metabolic model of a polar diatom, Fragilariopsis cylindrus, and studied the organism’s resilience through computational sensitivity analysis. The cover image (created with BioRender.com) shows a scheme of the metabolic model across compartments, coupling nutrient uptake and light absorption with algal growth. It was found that growth is robust to a wide array of cellular perturbations including changes in cell biochemical composition and reaction deletions. Interestingly, the expression of highly divergent alleles, which are unique to F. cylindrus, as well as duplicated enzymes, increases its metabolic robustness, shedding new light on its ecological success. View this paper.
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Articles (18)

  • Article
  • Open Access
33 Citations
6,479 Views
25 Pages

β2-Adrenergic Signalling Promotes Cell Migration by Upregulating Expression of the Metastasis-Associated Molecule LYPD3

  • Michael Gruet,
  • Daniel Cotton,
  • Clare Coveney,
  • David J. Boocock,
  • Sarah Wagner,
  • Lucie Komorowski,
  • Robert C. Rees,
  • A. Graham Pockley,
  • A. Christopher Garner and
  • John D. Wallis
  • + 2 authors

22 February 2020

Metastasis is associated with poor prognosis in breast cancer. Although some studies suggest beta-blockers increase survival by delaying metastasis, others have been discordant. This study provides both insights into the anomalous findings and identi...

  • Article
  • Open Access
36 Citations
4,228 Views
18 Pages

21 February 2020

Transport in water is the most common method for achieving high survival rates when transporting cultured fish in China; yet, transport success relies on proper water quality and conditions. This research was designed to explore the effects of ascorb...

  • Review
  • Open Access
45 Citations
8,213 Views
23 Pages

A Review of Diatom Lipid Droplets

  • Ben Leyland,
  • Sammy Boussiba and
  • Inna Khozin-Goldberg

21 February 2020

The dynamic nutrient availability and photon flux density of diatom habitats necessitate buffering capabilities in order to maintain metabolic homeostasis. This is accomplished by the biosynthesis and turnover of storage lipids, which are sequestered...

  • Article
  • Open Access
11 Citations
4,685 Views
17 Pages

19 February 2020

Merkel cell carcinoma (MCC) is a highly lethal skin cancer. MCC tumors rapidly develop resistance to the chemotherapies tested to date. While PD-1/PD-L1 immune checkpoint blockade has demonstrated success in MCC treatment, a significant portion of MC...

  • Article
  • Open Access
8 Citations
4,120 Views
9 Pages

From One Ejaculate to Another: Transference of Sperm Traits via Seminal Plasma Supplementation in the Ram

  • Christine Green,
  • Jessica P. Rickard,
  • Simon P. de Graaf and
  • Angela J. Crean

18 February 2020

Males can adjust sperm motility instantaneously in response to the perceived risk of sperm competition. The speed of this response suggests that sperm motility is regulated by changes in seminal plasma rather than changes in the sperm cells themselve...

  • Review
  • Open Access
45 Citations
6,322 Views
23 Pages

Extracellular Traps: An Ancient Weapon of Multiple Kingdoms

  • Ariane Neumann,
  • Graham Brogden and
  • Maren von Köckritz-Blickwede

18 February 2020

The discovery, in 2004, of extracellular traps released by neutrophils has extended our understanding of the mode of action of various innate immune cells. This fascinating discovery demonstrated the extracellular trapping and killing of various path...

  • Communication
  • Open Access
20 Citations
4,922 Views
10 Pages

17 February 2020

Glioblastoma is the most aggressive and malignant primary brain tumor in adults and has a poor patient survival of only 20 months after diagnosis. This poor patient survival is at least partly caused by glioblastoma stem cells (GSCs), which are slowl...

  • Article
  • Open Access
14 Citations
6,597 Views
20 Pages

Genome-Scale Metabolic Reconstruction and in Silico Perturbation Analysis of the Polar Diatom Fragilariopsis cylindrus Predicts High Metabolic Robustness

  • Michel Lavoie,
  • Blanche Saint-Béat,
  • Jan Strauss,
  • Sébastien Guérin,
  • Antoine Allard,
  • Simon V. Hardy,
  • Angela Falciatore and
  • Johann Lavaud

17 February 2020

Diatoms are major primary producers in polar environments where they can actively grow under extremely variable conditions. Integrative modeling using a genome-scale model (GSM) is a powerful approach to decipher the complex interactions between comp...

  • Article
  • Open Access
9 Citations
7,689 Views
17 Pages

Morphological Features of the Anther Development in Tomato Plants with Non-Specific Male Sterility

  • Inna A. Chaban,
  • Neonila V. Kononenko,
  • Alexander A. Gulevich,
  • Liliya R. Bogoutdinova,
  • Marat R. Khaliluev and
  • Ekaterina N. Baranova

17 February 2020

The study was devoted to morphological and cytoembryological analysis of disorders in the anther and pollen development of transgenic tomato plants with a normal and abnormal phenotype, which is characterized by the impaired development of generative...

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Biology - ISSN 2079-7737