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Biosensors, Volume 8, Issue 1 (March 2018)
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Cover Story (view full-size image) As competitors of neurotransmitters like dopamine (DA), antipsychotic drugs (APD) bind to the [...] Read more. As competitors of neurotransmitters like dopamine (DA), antipsychotic drugs (APD) bind to the receptor sites in neurons and block the biological responses in vivo. Currently available in vitro APD screening platforms are developed on the basis of drug-receptor interaction monitoring with fluorescent or radioactive methods that require lengthy and troublesome labelling steps. In this work, we unraveled the unique potentials of label-free electrochemical and optical biosensors for cost-efficient and simpler APD screening. Specifically, we demonstrate the utility of electrochemical impedance spectroscopy and nanoplasmonic sensing for rapid analysis and identification of APD candidates via drug-receptor in vitro assays. View this paper