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Biosensors, Volume 8, Issue 1

2018 March - 26 articles

Cover Story: As competitors of neurotransmitters like dopamine (DA), antipsychotic drugs (APD) bind to the receptor sites in neurons and block the biological responses in vivo. Currently available in vitro APD screening platforms are developed on the basis of drug-receptor interaction monitoring with fluorescent or radioactive methods that require lengthy and troublesome labelling steps. In this work, we unraveled the unique potentials of label-free electrochemical and optical biosensors for cost-efficient and simpler APD screening. Specifically, we demonstrate the utility of electrochemical impedance spectroscopy and nanoplasmonic sensing for rapid analysis and identification of APD candidates via drug-receptor in vitro assays. View this paper
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Articles (26)

  • Article
  • Open Access
21 Citations
6,035 Views
9 Pages

The Use of Biosensors to Explore the Potential of Probiotic Strains to Reduce the SOS Response and Mutagenesis in Bacteria

  • Vladimir Anatolievich Chistyakov,
  • Evgeniya Valer’evna Prazdnova,
  • Maria Sergeevna Mazanko and
  • Anzhelica Borisovna Bren

16 March 2018

A model system based on the Escherichia coli MG1655 (pRecA-lux) Lux-biosensor was used to evaluate the ability of the fermentates of eight probiotic strains to reduce the SOS response stimulated by ciprofloxacin in bacteria and mutagenesis mediated b...

  • Feature Paper
  • Article
  • Open Access
16 Citations
6,803 Views
11 Pages

Fabrication of SrTiO3 Layer on Pt Electrode for Label-Free Capacitive Biosensors

  • Francesca Malvano,
  • Luigi Maritato,
  • Giovanni Carapella,
  • Pasquale Orgiani,
  • Roberto Pilloton,
  • Marisa Di Matteo and
  • Donatella Albanese

16 March 2018

Due to their interesting ferroelectric, conductive and dielectric properties, in recent years, perovskite-structured materials have begun to attract increasing interest in the biosensing field. In this study, a strontium titanate perovskite layer (Sr...

  • Feature Paper
  • Review
  • Open Access
102 Citations
16,573 Views
17 Pages

Calibration of Minimally Invasive Continuous Glucose Monitoring Sensors: State-of-The-Art and Current Perspectives

  • Giada Acciaroli,
  • Martina Vettoretti,
  • Andrea Facchinetti and
  • Giovanni Sparacino

13 March 2018

Minimally invasive continuous glucose monitoring (CGM) sensors are wearable medical devices that provide real-time measurement of subcutaneous glucose concentration. This can be of great help in the daily management of diabetes. Most of the commercia...

  • Review
  • Open Access
221 Citations
25,472 Views
34 Pages

Biosensors for Sustainable Food Engineering: Challenges and Perspectives

  • Suresh Neethirajan,
  • Vasanth Ragavan,
  • Xuan Weng and
  • Rohit Chand

12 March 2018

Current food production faces tremendous challenges from growing human population, maintaining clean resources and food qualities, and protecting climate and environment. Food sustainability is mostly a cooperative effort resulting in technology deve...

  • Feature Paper
  • Article
  • Open Access
46 Citations
10,584 Views
8 Pages

Accuracy of Continuous Glucose Monitoring before, during, and after Aerobic and Anaerobic Exercise in Patients with Type 1 Diabetes Mellitus

  • Lyvia Biagi,
  • Arthur Bertachi,
  • Carmen Quirós,
  • Marga Giménez,
  • Ignacio Conget,
  • Jorge Bondia and
  • Josep Vehí

9 March 2018

Continuous glucose monitoring (CGM) plays an important role in treatment decisions for patients with type 1 diabetes under conventional or closed-loop therapy. Physical activity represents a great challenge for diabetes management as well as for CGM...

  • Article
  • Open Access
9 Citations
9,154 Views
12 Pages

A DNA-Based Assay for Digoxin Detection

  • Michael V. Kjelstrup,
  • Line D. F. Nielsen,
  • Malthe Hansen-Bruhn and
  • Kurt V. Gothelf

6 March 2018

The most common method for quantifying small-molecule drugs in blood samples is by liquid chromatography in combination with mass spectrometry. Few immuno-based assays are available for the detection of small-molecule drugs in blood. Here we report o...

  • Article
  • Open Access
13 Citations
8,610 Views
11 Pages

Amperometric Self-Referencing Ceramic Based Microelectrode Arrays for D-Serine Detection

  • Diana Campos-Beltrán,
  • Åsa Konradsson-Geuken,
  • Jorge E. Quintero and
  • Lisa Marshall

6 March 2018

D-serine is the major D-amino acid in the mammalian central nervous system. As the dominant co-agonist of the endogenous synaptic NMDA receptor, D-serine plays a role in synaptic plasticity, learning, and memory. Alterations in D-serine are linked to...

  • Article
  • Open Access
44 Citations
8,608 Views
13 Pages

A Nanostructured Sensor Based on Gold Nanoparticles and Nafion for Determination of Uric Acid

  • Natalia Stozhko,
  • Maria Bukharinova,
  • Leonid Galperin and
  • Khiena Brainina

6 March 2018

The paper discusses the mechanism of uric acid (UA) electrooxidation occurring on the surface of gold nanoparticles. It has been shown that the electrode process is purely electrochemical, uncomplicated with catalytic stages. The nanoeffects observed...

  • Article
  • Open Access
14 Citations
6,712 Views
10 Pages

28 February 2018

Here, we provide a method and apparatus for real-time compensation of the thermal effect of single free-standing piezoresistive microcantilever-based biosensors. The sensor chip contained an on-chip fixed piezoresistor that served as a temperature se...

  • Feature Paper
  • Review
  • Open Access
79 Citations
22,162 Views
30 Pages

26 February 2018

Designs and applications of microfluidics-based devices for molecular diagnostics (Nucleic Acid Amplification Tests, NAATs) in infectious disease testing are reviewed, with emphasis on minimally instrumented, point-of-care (POC) tests for resource-li...

  • Article
  • Open Access
71 Citations
8,317 Views
12 Pages

Ultrasensitive Determination of Malathion Using Acetylcholinesterase Immobilized on Chitosan-Functionalized Magnetic Iron Nanoparticles

  • Núbia Fernanda Marinho Rodrigues,
  • Sakae Yotsumoto Neto,
  • Rita De Cássia Silva Luz,
  • Flávio Santos Damos and
  • Hideko Yamanaka

13 February 2018

A renewable, disposable, low cost, and sensitive sensor for the detection of organophosphorus pesticides was constructed by immobilizing the acetylcholinesterase enzyme (AChE), via glutaraldehyde, on magnetic iron nanoparticles (Fe3O4) previously syn...

  • Article
  • Open Access
8 Citations
5,978 Views
12 Pages

11 February 2018

The investigation of contaminant impact on algae requires rapid and reliable cell collection and optical detection. The capability of alternative current (AC) dielectrophoresis (DEP) collection of whole cell arrays with combined fluorescence microsco...

  • Communication
  • Open Access
39 Citations
9,407 Views
11 Pages

Self-Organized Nanostructure Modified Microelectrode for Sensitive Electrochemical Glutamate Detection in Stem Cells-Derived Brain Organoids

  • Babak Nasr,
  • Rachael Chatterton,
  • Jason Hsien Ming Yong,
  • Pegah Jamshidi,
  • Giovanna Marisa D’Abaco,
  • Andrew Robin Bjorksten,
  • Omid Kavehei,
  • Gursharan Chana,
  • Mirella Dottori and
  • Efstratios Skafidas

5 February 2018

Neurons release neurotransmitters such as glutamate to communicate with each other and to coordinate brain functioning. As increased glutamate release is indicative of neuronal maturation and activity, a system that can measure glutamate levels over...

  • Article
  • Open Access
5 Citations
8,924 Views
11 Pages

Prolonged Corrosion Stability of a Microchip Sensor Implant during In Vivo Exposure

  • Paul Glogener,
  • Michael Krause,
  • Jens Katzer,
  • Markus A. Schubert,
  • Mario Birkholz,
  • Olaf Bellmann,
  • Claudia Kröger-Koch,
  • Harald M. Hammon,
  • Cornelia C. Metges and
  • Klaus P. Hoffmann
  • + 2 authors

1 February 2018

A microelectronic biosensor was subjected to in vivo exposure by implanting it in the vicinity of m. trapezii (Trapezius muscle) from cattle. The implant is intended for the continuous monitoring of glucose levels, and the study aimed at evaluating t...

  • Article
  • Open Access
32 Citations
10,424 Views
10 Pages

30 January 2018

A polyvinylidene fluoride (PVDF) film-based capacitive biosensor was developed for glucose sensing. This device consists of a PVDF film sandwiched between two electrodes. A capacitive biosensor measures the dielectric properties of the dielectric lay...

  • Feature Paper
  • Review
  • Open Access
124 Citations
14,159 Views
18 Pages

29 January 2018

With the rapid progress in nanotechnology and microengineering, point-of-care and personalised healthcare, based on wearable and implantable diagnostics, is becoming a reality. Enzymatic fuel cells (EFCs) hold great potential as a sustainable means t...

  • Article
  • Open Access
21 Citations
9,263 Views
10 Pages

24 January 2018

Carbon nanotube field-effect transistors are used extensively in ultra-sensitive biomolecule sensing applications. Along with high sensitivity, the possibility of regeneration is highly desired in bio-sensors. An important constituent of such bio-sen...

  • Article
  • Open Access
12 Citations
7,853 Views
13 Pages

24 January 2018

A colorimetric microarray for the multiplexed detection of recurrence of bladder cancer including protein markers interleukin-8 (IL8), decorin (DCN), and vascular endothelial growth factor (VEGF) was established to enable easy and cheap read-out by a...

  • Article
  • Open Access
32 Citations
7,193 Views
16 Pages

19 January 2018

This work reports a very simple approach for creating a synthetic antibody against any protein of interest and its application in potentiometric transduction. The selected protein was Breast Cancer Antigen (CA 15-3), which is implicated in breast can...

  • Feature Paper
  • Article
  • Open Access
66 Citations
15,325 Views
18 Pages

15 January 2018

Recently, inkjet-printing has gained increased popularity in applications such as flexible electronics and disposable sensors, as well as in wearable sensors because of its multifarious advantages. This work presents a novel, low-cost immobilization...

  • Feature Paper
  • Article
  • Open Access
12 Citations
10,658 Views
14 Pages

Mining the Potential of Label-Free Biosensors for In Vitro Antipsychotic Drug Screening

  • Tugba Kilic,
  • Maria Soler,
  • Nafiseh Fahimi-Kashani,
  • Hatice Altug and
  • Sandro Carrara

9 January 2018

The pharmaceutical industry is facing enormous challenges due to high drug attribution rates. For the past decades, novel methods have been developed for safety and efficacy testing, as well as for improving early development stages. In vitro screeni...

  • Article
  • Open Access
34 Citations
10,277 Views
13 Pages

6 January 2018

A cuprous oxide (Cu2O) thin layer served as the base for a non-enzymatic glucose sensor in an alkaline medium, 0.1 NaOH solution, with a linear range of 50–200 mg/dL using differential pulse voltammetry (DPV) measurement. An X-ray photoelectron spect...

  • Review
  • Open Access
214 Citations
27,415 Views
24 Pages

Electronic Tongue—A Tool for All Tastes?

  • Marta Podrażka,
  • Ewa Bączyńska,
  • Magdalena Kundys,
  • Paulina S. Jeleń and
  • Emilia Witkowska Nery

31 December 2017

Electronic tongue systems are traditionally used to analyse: food products, water samples and taste masking technologies for pharmaceuticals. In principle, their applications are almost limitless, as they are able to almost completely reduce the impa...

  • Article
  • Open Access
14 Citations
9,653 Views
14 Pages

An FT-Raman, FT-IR, and Quantum Chemical Investigation of Stanozolol and Oxandrolone

  • Tibebe Lemma,
  • Fabiano De Barros Souza,
  • Claudio A. Tellez Soto and
  • Airton A. Martin

26 December 2017

We have studied the Fourier Transform Infrared (FT-IR) and the Fourier transform Raman (FT-Raman) spectra of stanozolol and oxandrolone, and we have performed quantum chemical calculations based on the density functional theory (DFT) with a B3LYP/6-3...

  • Article
  • Open Access
26 Citations
9,990 Views
15 Pages

Label-Free Biosensor Detection of Endocrine Disrupting Compounds Using Engineered Estrogen Receptors

  • Rita La Spina,
  • Valentina E. V. Ferrero,
  • Venera Aiello,
  • Mattia Pedotti,
  • Luca Varani,
  • Teresa Lettieri,
  • Luigi Calzolai,
  • Willem Haasnoot and
  • Pascal Colpo

22 December 2017

Endocrine Disrupting Compounds (EDCs) are chemical substances shown to interfere with endogenous hormones affecting the endocrine, immune and nervous systems of mammals. EDCs are the causative agents of diseases including reproductive disorders and c...

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Biosensors - ISSN 2079-6374