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Biosensors 2018, 8(1), 26;

Fabrication of SrTiO3 Layer on Pt Electrode for Label-Free Capacitive Biosensors

Department of Industrial Engineering, University of Salerno, 84084 Fisciano, Italy
Department of Physics “ER Caianiello”, University of Salerno, 84084 Fisciano, Italy
Institute of Superconducting oxides and other innovative materials and devices of the National Council of Research (CNR), Unit Operative of Salerno, 84084 Fisciano, Italy
Institute of Crystallography of the National Council of Research (CNR), 00015 Monterotondo Scalo, Italy
Author to whom correspondence should be addressed.
Received: 22 February 2018 / Revised: 9 March 2018 / Accepted: 13 March 2018 / Published: 16 March 2018
(This article belongs to the Special Issue Label-free Biosensing)
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Due to their interesting ferroelectric, conductive and dielectric properties, in recent years, perovskite-structured materials have begun to attract increasing interest in the biosensing field. In this study, a strontium titanate perovskite layer (SrTiO3) has been synthesized on a platinum electrode and exploited for the development of an impedimetric label-free immunosensor for Escherichia coli O157:H7 detection. The electrochemical characterization of the perovskite-modified electrode during the construction of the immunosensor, as well as after the interaction with different E. coli O157:H7 concentrations, showed a reproducible decrease of the total capacitance of the system that was used for the analytical characterization of the immunosensor. Under optimized conditions, the capacitive immunosensor showed a linear relationship from to 1 to 7 log cfu/mL with a low detection limit of 1 log cfu/mL. Moreover, the atomic force microscopy (AFM) technique underlined the increase in roughness of the SrTiO3-modified electrode surface after antibody immobilization, as well as the effective presence of cells with the typical size of E. coli. View Full-Text
Keywords: biosensors; label-free; perovskite; strontium titanium oxide biosensors; label-free; perovskite; strontium titanium oxide

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Malvano, F.; Maritato, L.; Carapella, G.; Orgiani, P.; Pilloton, R.; Di Matteo, M.; Albanese, D. Fabrication of SrTiO3 Layer on Pt Electrode for Label-Free Capacitive Biosensors. Biosensors 2018, 8, 26.

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