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Biosensors, Volume 13, Issue 9

September 2023 - 65 articles

Cover Story: In this study, a modular, multi-purpose, and cost-effective electrochemical biosensor based on a five-stranded four-way junction (5S-4WJ) system was developed for SARS-CoV-2 (genes S and N) and influenza A virus (gene M) detection. The 5S-4WJ structure consists of an electrode-immobilized universal stem-loop (USL) strand, two auxiliary DNA strands, and a universal methylene blue redox strand (UMeB). The sequence-specific auxiliary DNA strands (m and f) ensure selectivity of the biosensor for target recognition utilizing the same USL and UMeB components. The biosensor exhibited minimal loss in the signal after rehybridization, demonstrating its potential as a viable multiplex assay for both current and future pathogens, with a low limit of quantification (LOQ) of as low as 17 pM. View this paper
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Articles (65)

  • Review
  • Open Access
13 Citations
4,747 Views
28 Pages

Unraveling the Possibilities: Recent Progress in DNA Biosensing

  • Meng Yu,
  • Tingli He,
  • Qianqian Wang and
  • Cheng Cui

18 September 2023

Due to the advantages of its numerous modification sites, predictable structure, high thermal stability, and excellent biocompatibility, DNA is the ideal choice as a key component of biosensors. DNA biosensors offer significant advantages over existi...

  • Article
  • Open Access
3 Citations
2,055 Views
11 Pages

18 September 2023

The colonization of some bacteria to their host cell is mediated by selective adhesion between adhesin and glycan. The evaluation of antiadhesive carbohydrates in vitro has great significance in discovering new antibacterial drugs. In this paper, a m...

  • Review
  • Open Access
47 Citations
7,842 Views
37 Pages

Immobilization of Enzyme Electrochemical Biosensors and Their Application to Food Bioprocess Monitoring

  • Ganchao Sun,
  • Xiaobo Wei,
  • Dianping Zhang,
  • Liben Huang,
  • Huiyan Liu and
  • Haitian Fang

17 September 2023

Electrochemical biosensors based on immobilized enzymes are among the most popular and commercially successful biosensors. The literature in this field suggests that modification of electrodes with nanomaterials is an excellent method for enzyme immo...

  • Review
  • Open Access
18 Citations
4,982 Views
28 Pages

Recent Uses of Paper Microfluidics in Isothermal Nucleic Acid Amplification Tests

  • Jocelyn Reynolds,
  • Reid S. Loeffler,
  • Preston J. Leigh,
  • Hannah A. Lopez and
  • Jeong-Yeol Yoon

15 September 2023

Isothermal nucleic acid amplification tests have recently gained popularity over polymerase chain reaction (PCR), as they only require a constant temperature and significantly simplify nucleic acid amplification. Recently, numerous attempts have been...

  • Review
  • Open Access
32 Citations
6,702 Views
28 Pages

Advancing Healthcare: Synergizing Biosensors and Machine Learning for Early Cancer Diagnosis

  • Mahtab Kokabi,
  • Muhammad Nabeel Tahir,
  • Darshan Singh and
  • Mehdi Javanmard

13 September 2023

Cancer is a fatal disease and a significant cause of millions of deaths. Traditional methods for cancer detection often have limitations in identifying the disease in its early stages, and they can be expensive and time-consuming. Since cancer typica...

  • Article
  • Open Access
4 Citations
2,053 Views
11 Pages

12 September 2023

Mitochondrial hypochlorite (ClO−) plays important and often contradictory roles in maintaining the redox balance of mitochondria. Abnormal ClO− levels can induce mitochondrial inactivation and further cause cell apoptosis. Herein, we have...

  • Review
  • Open Access
6 Citations
2,792 Views
18 Pages

Circulating Tumor Cells Adhesion: Application in Biosensors

  • Eduarda B. Paglia,
  • Estela K. K. Baldin,
  • Gabriela P. Freitas,
  • Thalyta S. A. Santiago,
  • João B. M. R. Neto,
  • Jorge V. L. Silva,
  • Hernandes F. Carvalho and
  • Marisa M. Beppu

12 September 2023

The early and non-invasive diagnosis of tumor diseases has been widely investigated by the scientific community focusing on the development of sensors/biomarkers that act as a way of recognizing the adhesion of circulating tumor cells (CTCs). As a ch...

  • Article
  • Open Access
14 Citations
3,065 Views
16 Pages

Truncated Electrochemical Aptasensor with Enhanced Antifouling Capability for Highly Sensitive Serotonin Detection

  • Ziheng Hu,
  • Ruifeng Zhu,
  • Gabriela Figueroa-Miranda,
  • Lei Zhou,
  • Lingyan Feng,
  • Andreas Offenhäusser and
  • Dirk Mayer

11 September 2023

Accurate determination of serotonin (ST) provides insight into neurological processes and enables applications in clinical diagnostics of brain diseases. Herein, we present an electrochemical aptasensor based on truncated DNA aptamers and a polyethyl...

  • Review
  • Open Access
17 Citations
5,182 Views
24 Pages

SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease

  • Feng Gao,
  • Fang Li,
  • Jianhao Wang,
  • Hang Yu,
  • Xiang Li,
  • Hongyu Chen,
  • Jiabei Wang,
  • Dongdong Qin,
  • Yiyi Li and
  • Songyan Liu
  • + 2 authors

11 September 2023

Alzheimer’s disease (AD) is a leading cause of dementia, impacting millions worldwide. However, its complex neuropathologic features and heterogeneous pathophysiology present significant challenges for diagnosis and treatment. To address the ur...

  • Article
  • Open Access
3 Citations
2,818 Views
12 Pages

9 September 2023

We report a versatile platform based on an array of porous silicon (PSi) thin films that can identify analytes based on their physical and chemical properties without the use of specific capture agents. The ability of this system to reproducibly clas...

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Biosensors - ISSN 2079-6374Creative Common CC BY license