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Biosensors, Volume 12, Issue 2

February 2022 - 89 articles

Cover Story: In the era of personalized medicine, liquid biopsy represents a minimally invasive valuable tool for mutational profiling of tumors. It involves the detection of mutations in circulating tumor DNA (ctDNA) that represents a challenging analyte. In this study, a rapid, gold nanoparticle-based multiplex strip test was developed for visual detection of mutations in ctDNA. The strip-test achieved visual multiplex detection of clinically relevant KRAS mutations in blood samples of colorectal cancer patients with high specificity, repeatability, and a 15 min analysis time. This test represents a simple, rapid, cost-effective, portable, universal test with advanced multiplexing potential that shows great promise as a diagnostic tool for liquid biopsy applications. View this paper
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Articles (89)

  • Article
  • Open Access
19 Citations
4,915 Views
13 Pages

Colorimetric Biosensor Based on Magnetic Enzyme and Gold Nanorods for Visual Detection of Fish Freshness

  • Xia Xu,
  • Xiaotian Wu,
  • Shunqian Zhuang,
  • Yucong Zhang,
  • Yuting Ding and
  • Xuxia Zhou

21 February 2022

Histamine, an important safety index for aquatic products, can also be used as a freshness indicator for red-fleshed fish. In this work, magnetic graphene oxide (Fe3O4@GO, MGO) was applied to immobilize diamine oxidase (DAO) through a method of adsor...

  • Article
  • Open Access
13 Citations
4,313 Views
17 Pages

Radiometal-Based PET/MRI Contrast Agents for Sensing Tumor Extracellular pH

  • Alyssa C. Pollard,
  • Jorge de la Cerda,
  • F. William Schuler,
  • Tyler R. Pollard,
  • Aikaterini Kotrotsou,
  • Federica Pisaneschi and
  • Mark D. Pagel

20 February 2022

Acidosis is a useful biomarker for tumor diagnoses and for evaluating early response to anti-cancer treatments. Despite these useful applications, there are few methods for non-invasively measuring tumor extracellular pH, and none are routinely used...

  • Article
  • Open Access
26 Citations
6,785 Views
18 Pages

A Wearable and Real-Time Pulse Wave Monitoring System Based on a Flexible Compound Sensor

  • Xiaoxiao Kang,
  • Jun Zhang,
  • Zheming Shao,
  • Guotai Wang,
  • Xingguang Geng,
  • Yitao Zhang and
  • Haiying Zhang

20 February 2022

Continuous monitoring of pulse waves plays a significant role in reflecting physical conditions and disease diagnosis. However, the current collection equipment cannot simultaneously achieve wearable and continuous monitoring under varying pressure a...

  • Communication
  • Open Access
19 Citations
8,845 Views
11 Pages

The Introduction of a New Diagnostic Tool in Forensic Pathology: LiDAR Sensor for 3D Autopsy Documentation

  • Aniello Maiese,
  • Alice Chiara Manetti,
  • Costantino Ciallella and
  • Vittorio Fineschi

19 February 2022

Autopsy is a complex and unrepeatable procedure. It is essential to have the possibility of reviewing the autoptic findings, especially when it is done for medico-legal purposes. Traditional photography is not always adequate to record forensic pract...

  • Review
  • Open Access
23 Citations
5,935 Views
25 Pages

19 February 2022

Lanthanide-doped nanoparticles possess numerous advantages including tunable luminescence emission, narrow peak width and excellent optical and thermal stability, especially concerning the long lifetime from microseconds to milliseconds. Differing fr...

  • Communication
  • Open Access
16 Citations
3,360 Views
10 Pages

Carnation-like Morphology of BiVO4-7 Enables Sensitive Photoelectrochemical Determination of Cr(VI) in the Food and Environment

  • Wenqin Wu,
  • Zhao Tan,
  • Xiao Chen,
  • Xiaomei Chen,
  • Ling Cheng,
  • Huimin Wu,
  • Peiwu Li and
  • Zhaowei Zhang

19 February 2022

Hexavalent chromium, namely, Cr(VI), is a significant threat to ecological and food safety. Current detection methods are not sensitive to Cr(VI). A photoelectrochemical (PEC) sensor based on bismuth vanadate (BiVO4) was developed for sensitive detec...

  • Article
  • Open Access
8 Citations
5,308 Views
20 Pages

A Hybrid Titanium-Softmaterial, High-Strength, Transparent Cranial Window for Transcranial Injection and Neuroimaging

  • Nana Yang,
  • Fengyu Liu,
  • Xinyue Zhang,
  • Chenni Chen,
  • Zhiyuan Xia,
  • Su Fu,
  • Jiaxin Wang,
  • Jingjing Xu,
  • Shuang Cui and
  • Yong Zhang
  • + 4 authors

18 February 2022

A transparent and penetrable cranial window is essential for neuroimaging, transcranial injection and comprehensive understanding of cortical functions. For these applications, cranial windows made from glass coverslip, polydimethylsiloxane (PDMS), p...

  • Article
  • Open Access
19 Citations
5,743 Views
14 Pages

FDTD Analysis of Hotspot-Enabling Hybrid Nanohole-Nanoparticle Structures for SERS Detection

  • Juan Gomez-Cruz,
  • Yazan Bdour,
  • Kevin Stamplecoskie and
  • Carlos Escobedo

17 February 2022

Metallic nanoparticles (MNPs) and metallic nanostructures are both commonly used, independently, as SERS substrates due to their enhanced plasmonic activity. In this work, we introduce and investigate a hybrid nanostructure with strong SERS activity...

  • Article
  • Open Access
7 Citations
4,824 Views
15 Pages

Detection and Quantification of Tp53 and p53-Anti-p53 Autoantibody Immune Complex: Promising Biomarkers in Early Stage Lung Cancer Diagnosis

  • Keum-Soo Song,
  • Satish Balasaheb Nimse,
  • Shrikant Dashrath Warkad,
  • Jung-Hoon Kim,
  • Hey-Jin Kim and
  • Taisun Kim

16 February 2022

Lung cancer is a leading cause of death worldwide, claiming nearly 1.80 million lives in 2020. Screening with low-dose computed tomography (LDCT) reduces lung cancer mortality by about 20% compared to standard chest X-rays among current or heavy smok...

  • Perspective
  • Open Access
27 Citations
9,085 Views
10 Pages

Academic User View: Organ-on-a-Chip Technology

  • Mathias Busek,
  • Aleksandra Aizenshtadt,
  • Mikel Amirola-Martinez,
  • Ludivine Delon and
  • Stefan Krauss

16 February 2022

Organ-on-a-Chip (OoC) systems bring together cell biology, engineering, and material science for creating systems that recapitulate the in vivo microenvironment of tissues and organs. The versatility of OoC systems enables in vitro models for studyin...

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Biosensors - ISSN 2079-6374