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Open AccessArticle

Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors

1
Department for Innovation Engineering, University of Salento, Piazza Tancredi, I-73100 Lecce, Italy
2
Department of Mathematics and Physics “Ennio de Giorgi”, University of Salento, Piazza Tancredi, I-73100 Lecce, Italy
3
National Institute for Nuclear Physics, I.N.F.N, Lecce Unit, I-73100 Lecce, Italy
4
Oncology Unit “Vito Fazzi” Hospital-Lecce, I-73100 Lecce, Italy
*
Author to whom correspondence should be addressed.
Biosensors 2020, 10(9), 106; https://doi.org/10.3390/bios10090106
Received: 15 July 2020 / Revised: 15 August 2020 / Accepted: 21 August 2020 / Published: 24 August 2020
(This article belongs to the Section Biosensor and Bioelectronic Devices)
Cytokines are a family of proteins which play a major role in the regulation of the immune system and the development of several diseases, from rheumatoid arthritis to cancer and, more recently, COVID-19. Therefore, many efforts are currently being developed to improve therapy and diagnosis, as well as to produce inhibitory drugs and biosensors for a rapid, minimally invasive, and effective detection. In this regard, even more efficient cytokine receptors are under investigation. In this paper we analyze a set of IL-6 cytokine receptors, investigating their topological features by means of a theoretical approach. Our results suggest a topological indicator that may help in the identification of those receptors having the highest complementarity with the protein, a feature expected to ensure a stable binding. Furthermore, we propose and discuss the use of these receptors in an idealized experimental setup. View Full-Text
Keywords: IL-6 cytokine; biosensors; Proteotronics; aptamers; topological analysis IL-6 cytokine; biosensors; Proteotronics; aptamers; topological analysis
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MDPI and ACS Style

Alfinito, E.; Beccaria, M.; Ciccarese, M. Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors. Biosensors 2020, 10, 106.

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