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Biosensors, Volume 10, Issue 9

September 2020 - 28 articles

Cover Story: Cytokine IL-6 plays a major role in several inflammatory diseases, from rheumatoid arthritis to cancer, and more recently, in COVID-19 pneumonia. In the aim of producing highly sensitive and selective biosensors, we performed a virtual comparison among different IL-6 receptors, two Fabs, an aptamer, a clinical antibody as well as the natural receptors of this protein. The procedure requires translating the biomolecules (the protein alone and complexed with its receptors) into complex elec-trical networks, then allowing a flow of electrons to cross them, in such a way that the electron flux works like a probe exploring the network topology. The selected receptors were ranked accounting for their topological complementarity with IL-6. Two of the analyzed receptors are endorsed in a would-be electrochemical biosensor. View this pa-per.
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Articles (28)

  • Review
  • Open Access
56 Citations
11,599 Views
39 Pages

Electrochemiluminescence Biosensors Using Screen-Printed Electrodes

  • Emiliano Martínez-Periñán,
  • Cristina Gutiérrez-Sánchez,
  • Tania García-Mendiola and
  • Encarnación Lorenzo

9 September 2020

Electrogenerated chemiluminescence (also called electrochemiluminescence (ECL)) has become a great focus of attention in different fields of analysis, mainly as a consequence of the potential remarkably high sensitivity and wide dynamic range. In the...

  • Article
  • Open Access
2 Citations
3,087 Views
11 Pages

9 September 2020

The use of insoluble bismuth salts, typically BiPO4, is known to be a viable alternative to classical Bi3+ ion electrochemical reduction for the preparation of bismuth film electrodes (BiFE) on screen-printed electrodes. The freshly prepared electrod...

  • Article
  • Open Access
5 Citations
3,133 Views
12 Pages

Transient Effect at the Onset of Human Running

  • Christian Weich,
  • Manfred M. Vieten and
  • Randall L. Jensen

8 September 2020

While training and competing as a runner, athletes often sense an unsteady feeling during the first meters on the road. This sensation, termed as transient effect, disappears after a short period as the runners approach their individual running rhyth...

  • Article
  • Open Access
7 Citations
3,864 Views
11 Pages

7 September 2020

A carbon nanofiber enriched 8-channel screen-printed electrochemical array was used for the impedimetric detection of SNP related to Factor V Leiden (FV Leiden) mutation, which is the most common inherited form of thrombophilia. FV Leiden mutation se...

  • Review
  • Open Access
30 Citations
8,301 Views
27 Pages

Printed Electrodes in Microfluidic Arrays for Cancer Biomarker Protein Detection

  • Lasangi Dhanapala,
  • Colleen E. Krause,
  • Abby L. Jones and
  • James F. Rusling

7 September 2020

Medical diagnostics is trending towards a more personalized future approach in which multiple tests can be digitized into patient records. In cancer diagnostics, patients can be tested for individual protein and genomic biomarkers that detect cancers...

  • Article
  • Open Access
22 Citations
5,998 Views
8 Pages

A Self-Powered Biosensor for the Detection of Glutathione

  • Brandon G. Roy,
  • Julia L. Rutherford,
  • Anna E. Weaver,
  • Kevin Beaver and
  • Michelle Rasmussen

3 September 2020

Glutathione is an important biological molecule which can be an indicator of numerous diseases. A method for self-powered detection of glutathione levels in solution has been developed using an enzymatic biofuel cell. The device consists of a glucose...

  • Review
  • Open Access
20 Citations
5,161 Views
19 Pages

Biosensors for Antioxidants Detection: Trends and Perspectives

  • Melinda David,
  • Monica Florescu and
  • Camelia Bala

1 September 2020

Herein we review the recent advances in biosensors for antioxidants detection underlying principles particularly emphasizing advantages along with limitations regarding the ability to discriminate between the specific antioxidant or total content. Re...

  • Article
  • Open Access
16 Citations
5,869 Views
10 Pages

1 September 2020

A colorimetric assay was developed for the detection of biothiols, based on the peroxidase-like activity of iodine-capped gold nanoparticles (AuNPs). These AuNPs show a synergetic effect in the form of peroxidase-mimicking activity at the interface o...

  • Review
  • Open Access
109 Citations
11,618 Views
35 Pages

28 August 2020

Organs-on-chip (OoC), often referred to as microphysiological systems (MPS), are advanced in vitro tools able to replicate essential functions of human organs. Owing to their unprecedented ability to recapitulate key features of the native cellular e...

  • Article
  • Open Access
47 Citations
5,981 Views
10 Pages

28 August 2020

Lactic acid plays an important role as a biochemical indicator for sports medicine and clinical diagnosis. The detection of lactic acid in sweat is a promising technique without any intrusive inconvenience or risk of infection. In this study, we pres...

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Biosensors - ISSN 2079-6374