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Journal of Functional Biomaterials, Volume 13, Issue 1

2022 March - 32 articles

Cover Story: To combat device-associated infections and drug resistance, a local and controlled-release system which can release antibiotics in response to bacterial infected signals is necessary in antibacterial coating. Herein, a multi-stimulus responsive multilayer antibacterial coating was prepared through layer-by-layer self-assembly of montmorillonite, chlorhexidine acetate, and poly (protocatechuic acid-polyethylene glycol 1000-bis (phenylboronic acid carbamoyl) cystamine). The coating can be covered on various substrates and achieve controlled release of chlorhexidine acetate and kill more than 99% of bacteria within 4 hours. View this paper
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Articles (32)

  • Feature Paper
  • Article
  • Open Access
22 Citations
5,244 Views
11 Pages

Dental Poly(methyl methacrylate)-Based Resin Containing a Nanoporous Silica Filler

  • Kentaro Hata,
  • Hiroshi Ikeda,
  • Yuki Nagamatsu,
  • Chihiro Masaki,
  • Ryuji Hosokawa and
  • Hiroshi Shimizu

Poly(methyl methacrylate) (PMMA)-based resins have been conventionally used in dental prostheses owing to their good biocompatibility. However, PMMA-based resins have relatively poor mechanical properties. In the present study, a novel nanoporous sil...

  • Article
  • Open Access
29 Citations
4,950 Views
14 Pages

Engineering Nanopatterned Structures to Orchestrate Macrophage Phenotype by Cell Shape

  • Kai Li,
  • Lin Lv,
  • Dandan Shao,
  • Youtao Xie,
  • Yunzhen Cao and
  • Xuebin Zheng

Physical features on the biomaterial surface are known to affect macrophage cell shape and phenotype, providing opportunities for the design of novel “immune-instructive” topographies to modulate foreign body response. The work presented...

  • Feature Paper
  • Article
  • Open Access
6 Citations
4,254 Views
19 Pages

Exosomes from cancer cells are implicated in cancer progression and metastasis, carrying immunosuppressive factors that limit the antitumor abilities of immune cells. The development of a real-time, 3D cell/scaffold construct flow perfusion system ha...

  • Article
  • Open Access
6 Citations
4,708 Views
10 Pages

Magnification of Iris through Clear Acrylic Resin in Ocular Prosthesis

  • Dinesh Rokaya,
  • Jidapa Kritsana,
  • Pokpong Amornvit,
  • Nagendra Dhakal,
  • Zohaib Khurshid,
  • Muhammad Sohail Zafar and
  • Preamjit Saonanon

The study on the magnification of the clear acrylic resin in prosthetic dentistry is important but lacking. Hence, this research aimed to investigate the magnification of the iris in the ocular prosthesis with various thicknesses of clear heat cure a...

  • Article
  • Open Access
21 Citations
7,718 Views
13 Pages

Bone is a complex hierarchical tissue composed of organic and inorganic materials that provide structure, support, and protection to organs. However, there are some critical size defects that are unable to regenerate on their own and therefore requir...

  • Review
  • Open Access
131 Citations
11,225 Views
35 Pages

Two-Dimensional Nanomaterials beyond Graphene for Biomedical Applications

  • Maryam Derakhshi,
  • Sahar Daemi,
  • Pegah Shahini,
  • Afagh Habibzadeh,
  • Ebrahim Mostafavi and
  • Ali Akbar Ashkarran

Two-dimensional (2D) nanomaterials (e.g., graphene) have shown to have a high potential in future biomedical applications due to their unique physicochemical properties such as unusual electrical conductivity, high biocompatibility, large surface are...

  • Article
  • Open Access
16 Citations
4,347 Views
11 Pages

Surface Properties of Ti6Al7Nb Alloy: Surface Free Energy and Bacteria Adhesion

  • Monika Krzywicka,
  • Jolanta Szymańska,
  • Szymon Tofil,
  • Anna Malm and
  • Agnieszka Grzegorczyk

The laser micro-machining was carried out on a station equipped with a TruMicro 5325c laser emitting ultraviolet radiation (343 nm wavelength) in picosecond pulses. On the surface of the Ti6Al7Nb alloy, dimple texturing with a constant diameter of ~2...

  • Feature Paper
  • Article
  • Open Access
11 Citations
3,473 Views
16 Pages

The selection of restorative materials with regard to the longevity and durability of a restoration is of crucial importance for daily dental practice and requires that the degradation of the material in the oral environment can be assessed. The aim...

  • Article
  • Open Access
23 Citations
5,873 Views
17 Pages

Multi-Stimulus Responsive Multilayer Coating for Treatment of Device-Associated Infections

  • Wenlong Li,
  • Guanping Hua,
  • Jingfeng Cai,
  • Yaming Zhou,
  • Xi Zhou,
  • Miao Wang,
  • Xiumin Wang,
  • Baoqing Fu and
  • Lei Ren

Antibacterial coating with antibiotics is highly effective in avoiding device-associated infections (DAIs) which is an unsolved healthcare problem that causes significant morbidity and mortality rates. However, bacterial drug resistance caused by unc...

  • Article
  • Open Access
11 Citations
3,369 Views
18 Pages

The Comparison of Advanced Electrospun Materials Based on Poly(-3-hydroxybutyrate) with Natural and Synthetic Additives

  • Polina Tyubaeva,
  • Ivetta Varyan,
  • Alexey Krivandin,
  • Olga Shatalova,
  • Svetlana Karpova,
  • Anton Lobanov,
  • Anatoly Olkhov and
  • Anatoly Popov

The comparison of the effect of porphyrins of natural and synthetic origin containing the same metal atom on the structure and properties of the semi-crystalline polymer matrix is of current concern. A large number of modifying additives and biodegra...

  • Article
  • Open Access
11 Citations
3,713 Views
16 Pages

Osseointegration at Implants Installed in Composite Bone: A Randomized Clinical Trial on Sinus Floor Elevation

  • Mitsuo Kotsu,
  • Karol Alí Apaza Alccayhuaman,
  • Mauro Ferri,
  • Giovanna Iezzi,
  • Adriano Piattelli,
  • Natalia Fortich Mesa and
  • Daniele Botticelli

Osseointegration of implants installed in conjunction with sinus floor elevation might be affected by the presence of residual graft. The implant surface characteristics and the protection of the access window using a collagen membrane might influenc...

  • Article
  • Open Access
2 Citations
3,547 Views
17 Pages

SpAD Biofunctionalized Cellulose Acetate Scaffolds Inhibit Staphylococcus aureus Adherence in a Coordinating Function with the von Willebrand A1 Domain (vWF A1)

  • Stefanos Pendas,
  • Antonis Asiminas,
  • Alexandros Katranidis,
  • Costas Tsioptsias,
  • Maria Pitou,
  • Georgios Papadopoulos and
  • Theodora Choli-Papadopoulou

Staphylococcus aureus is one of the major pathogens causing and spreading hospital acquired infections. Since it is highly resistant to new generation antibiotics, novel strategies have to be developed such as the construction of biofunctionalized no...

  • Article
  • Open Access
12 Citations
4,216 Views
15 Pages

Numerical Simulation Study on Relationship between the Fracture Mechanisms and Residual Membrane Stresses of Metallic Material

  • Yan Yik Lim,
  • Azizi Miskon,
  • Ahmad Mujahid Ahmad Zaidi,
  • Megat Mohamad Hamdan Megat Ahmad and
  • Muhamad Abu Bakar

The distribution and dissipation energies in fracture mechanisms were a critical challenge to derive, especially for this ultra-thin sample. The membrane failure, which is the end of the fracture mechanisms, is a result of the cone wave reflections f...

  • Article
  • Open Access
18 Citations
7,466 Views
13 Pages

Properties of A Model Self-Healing Microcapsule-Based Dental Composite Reinforced with Silica Nanoparticles

  • Khaled Abid Althaqafi,
  • Abdulrahman Alshabib,
  • Julian Satterthwaite and
  • Nikolaos Silikas

Aim: The purpose of this study was to evaluate the mechanical properties of an experimental self-healing dental composite model (SHDC) composed of SiO2 nanoparticles with varying percentages of triethylene glycol dimethacrylate (TEGDMA) monomer and N...

  • Feature Paper
  • Article
  • Open Access
19 Citations
4,642 Views
14 Pages

Cement discoplasty has been developed to treat patients with advanced intervertebral disc degeneration. In discoplasty, poly(methylmethacrylate) (PMMA) bone cement is injected into the disc, leading to reduced pain and certain spinal alignment correc...

  • Article
  • Open Access
7 Citations
4,074 Views
19 Pages

Inhibitory Effects of Bacterial Silk-like Biopolymer on Herpes Simplex Virus Type 1, Adenovirus Type 7 and Hepatitis C Virus Infection

  • Esmail M. El-Fakharany,
  • Marwa M. Abu-Serie,
  • Noha H. Habashy,
  • Nehal M. El-Deeb,
  • Gadallah M. Abu-Elreesh,
  • Sahar Zaki and
  • Desouky Abd-EL-Haleem

Bacterial polymeric silk is produced by Bacillus sp. strain NE and is composed of two proteins, called fibroin and sericin, with several biomedical and biotechnological applications. In the current study and for the first time, the whole bacterial si...

  • Article
  • Open Access
22 Citations
6,519 Views
12 Pages

Effects of Silver Diamine Nitrate and Silver Diamine Fluoride on Dentin Remineralization and Cytotoxicity to Dental Pulp Cells: An In Vitro Study

  • Surapong Srisomboon,
  • Matana Kettratad,
  • Andrew Stray,
  • Phakkhananan Pakawanit,
  • Catleya Rojviriya,
  • Somying Patntirapong and
  • Piyaphong Panpisut

Silver diamine nitrate (SDN) is expected to help control caries similar to silver diamine fluoride (SDF). The aim of this study was to determine the mineral precipitation in demineralized dentin and the cytotoxicity of SDN and SDF to dental pulp cell...

  • Review
  • Open Access
110 Citations
19,590 Views
21 Pages

Fixed Prosthetic Restorations and Periodontal Health: A Narrative Review

  • Viritpon Srimaneepong,
  • Artak Heboyan,
  • Muhammad Sohail Zafar,
  • Zohaib Khurshid,
  • Anand Marya,
  • Gustavo V. O. Fernandes and
  • Dinesh Rokaya

Periodontal health plays an important role in the longevity of prosthodontic restorations. The issues of comparative assessment of prosthetic constructions are complicated and not fully understood. The aim of this article is to review and present the...

  • Article
  • Open Access
9 Citations
4,565 Views
12 Pages

Demineralized dentin matrix (DDM) treated with gamma irradiation (GR) has shown promising results as an allograft without any adverse effects in in vivo and clinical studies. The purpose of this study was to evaluate the effects of 15 and 25 kGy GR o...

  • Article
  • Open Access
43 Citations
10,273 Views
25 Pages

Biomimetic PLGA/Strontium-Zinc Nano Hydroxyapatite Composite Scaffolds for Bone Regeneration

  • Mozan Hassan,
  • Mohsin Sulaiman,
  • Priya Dharshini Yuvaraju,
  • Emmanuel Galiwango,
  • Ihtesham ur Rehman,
  • Ali H. Al-Marzouqi,
  • Abbas Khaleel and
  • Sahar Mohsin

Synthetic bone graft substitutes have attracted increasing attention in tissue engineering. This study aimed to fabricate a novel, bioactive, porous scaffold that can be used as a bone substitute. Strontium and zinc doped nano-hydroxyapatite (Sr/Zn n...

  • Feature Paper
  • Review
  • Open Access
94 Citations
9,193 Views
26 Pages

The Evolution of Molecular Recognition: From Antibodies to Molecularly Imprinted Polymers (MIPs) as Artificial Counterpart

  • Ortensia Ilaria Parisi,
  • Fabrizio Francomano,
  • Marco Dattilo,
  • Francesco Patitucci,
  • Sabrina Prete,
  • Fabio Amone and
  • Francesco Puoci

Molecular recognition is a useful property shared by various molecules, such as antibodies, aptamers and molecularly imprinted polymers (MIPs). It allows these molecules to be potentially involved in many applications including biological and pharmac...

  • Article
  • Open Access
9 Citations
3,997 Views
11 Pages

Low-diameter blood vessels are challenging to replace with more traditional synthetic vascular grafts. Therefore, the obvious choice is to try to regenerate small veins and arteries through tissue-engineering approaches. However, the layered structur...

  • Article
  • Open Access
4 Citations
4,294 Views
16 Pages

Precipitation is one of the most common processes to synthesize hydroxyapatite, which is the human body’s mineral forming bone and teeth, and the golden bioceramic material for bone repair. Generally, the washing step is important in the precip...

  • Feature Paper
  • Article
  • Open Access
14 Citations
5,582 Views
11 Pages

3D Printing of Hierarchically Porous Lattice Structures Based on Åkermanite Glass Microspheres and Reactive Silicone Binder

  • Arish Dasan,
  • Jozef Kraxner,
  • Luca Grigolato,
  • Gianpaolo Savio,
  • Hamada Elsayed,
  • Dušan Galusek and
  • Enrico Bernardo

The present study illustrates the manufacturing method of hierarchically porous 3D scaffolds based on åkermanite as a promising bioceramic for stereolithography. The macroporosity was designed by implementing 3D models corresponding to differen...

  • Article
  • Open Access
11 Citations
4,737 Views
17 Pages

Hemolytic Performance in Two Generations of the Sputnik Left Ventricular Assist Device: A Combined Numerical and Experimental Study

  • Alexandra N. Romanova,
  • Alexander A. Pugovkin,
  • Maxim V. Denisov,
  • Ivan A. Ephimov,
  • Dmitry V. Gusev,
  • Marian Walter,
  • Thomas Groth,
  • Olga L. Bockeria,
  • Tatyana G. Le and
  • Dmitry V. Telyshev
  • + 2 authors

Background: Currently, left ventricular assist devices (LVADs) are a successful surgical treatment for patients with end-stage heart failure on the waiting list or with contraindicated heart transplantation. In Russia, Sputnik 1 LVAD was also success...

  • Article
  • Open Access
2 Citations
3,816 Views
9 Pages

Do Human iPSC-Derived Cardiomyocytes Cultured on PLA Scaffolds Induce Expression of CD28/CTLA-4 by T Lymphocytes?

  • David Sergeevichev,
  • Victor Balashov,
  • Victoria Kozyreva,
  • Sophia Pavlova,
  • Maria Vasiliyeva,
  • Alexander Romanov and
  • Elena Chepeleva

Many research groups have developed various types of tissue-engineered cardiac constructs. However, the immunological properties of such artificial tissues are not yet fully understood. Previously, we developed microfiber scaffolds carrying human iPS...

  • Article
  • Open Access
1 Citations
3,071 Views
16 Pages

MacGyvered Multiproperty Materials Using Nanocarbon and Jam: A Spectroscopic, Electromagnetic, and Rheological Investigation

  • Antonino Cataldo,
  • Matteo La Pietra,
  • Leonardo Zappelli,
  • Davide Mencarelli,
  • Luca Pierantoni and
  • Stefano Bellucci

As part of a biopolymer matrix, pectin was investigated to obtain an engineered jam, due to its biodegradability. Only a few examples of pectin-based nanocomposites are present in the literature, and even fewer such bionanocomposites utilize nanocarb...

  • Article
  • Open Access
15 Citations
5,072 Views
20 Pages

Surface Functionalization of Poly(l-lactide-co-glycolide) Membranes with RGD-Grafted Poly(2-oxazoline) for Periodontal Tissue Engineering

  • Anna M. Tryba,
  • Małgorzata Krok-Borkowicz,
  • Michał Kula,
  • Natalia Piergies,
  • Mateusz Marzec,
  • Erik Wegener,
  • Justyna Frączyk,
  • Rainer Jordan,
  • Beata Kolesińska and
  • Elżbieta Pamuła
  • + 2 authors

Bone tissue defects resulting from periodontal disease are often treated using guided tissue regeneration (GTR). The barrier membranes utilized here should prevent soft tissue infiltration into the bony defect and simultaneously support bone regenera...

  • Article
  • Open Access
19 Citations
3,665 Views
10 Pages

Polydimethylsiloxane (PDMS) is one of the most superior materials and has been used as a substitute for vitreous humor in the human eye. In previous research, we have succeeded in producing PDMS with low and medium viscosity using octamethylcyclotetr...

  • Review
  • Open Access
95 Citations
19,449 Views
23 Pages

Bone tissue engineering strategies attempt to regenerate bone tissue lost due to injury or disease. Three-dimensional (3D) scaffolds maintain structural integrity and provide support, while improving tissue regeneration through amplified cellular res...

  • Feature Paper
  • Review
  • Open Access
646 Citations
34,715 Views
20 Pages

Properties and Applications of PDMS for Biomedical Engineering: A Review

  • Inês Miranda,
  • Andrews Souza,
  • Paulo Sousa,
  • João Ribeiro,
  • Elisabete M. S. Castanheira,
  • Rui Lima and
  • Graça Minas

Polydimethylsiloxane (PDMS) is an elastomer with excellent optical, electrical and mechanical properties, which makes it well-suited for several engineering applications. Due to its biocompatibility, PDMS is widely used for biomedical purposes. This...

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J. Funct. Biomater. - ISSN 2079-4983