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Journal of Functional Biomaterials, Volume 12, Issue 2

2021 June - 20 articles

Cover Story: β-d-N-acetyl-hexosaminidase A (HexA) is an acid hydrolase that is capable of degrading many biological substrates; additionally, it can play an important role in the biomedical field for the treatment of Tay–Sachs and Sandhoff diseases. A device with a stable enzyme was obtained with a method of covalent immobilization on polylactic acid (PLA) films. The results obtained showed an improvement in terms of kinetic parameters and stability to heat for the enzyme with an unexpected ability to maintain its functionality for a long period of time (over a year). The stability and functionality of the enzyme in its immobilized form are, therefore, extremely promising for potential biotechnological and biomedical applications. View this paper
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Articles (20)

  • Feature Paper
  • Review
  • Open Access
105 Citations
29,246 Views
17 Pages

Electrical Stimulation to Enhance Wound Healing

  • Saranya B. Rajendran,
  • Kirsty Challen,
  • Karen L. Wright and
  • John G. Hardy

Electrical stimulation (ES) can serve as a therapeutic modality accelerating the healing of wounds, particularly chronic wounds which have impaired healing due to complications from underlying pathology. This review explores how ES affects the cellul...

  • Feature Paper
  • Article
  • Open Access
10 Citations
4,063 Views
12 Pages

Bioactivity of an Experimental Dental Implant with Anodized Surface

  • Maria Fernanda Lima Villaça-Carvalho,
  • Juliani Caroline Ribeiro de Araújo,
  • Juliana Mariano Beraldo,
  • Renata Falchete do Prado,
  • Mari Eli Leonelli de Moraes,
  • Luiz Roberto Coutinho Manhães Junior,
  • Eduardo Norberto Codaro,
  • Heloisa Andrea Acciari,
  • João Paulo Barros Machado and
  • Luana Marotta Reis de Vasconcellos
  • + 3 authors

Background: Several studies proved that anodic oxidation improves osseointegration. This study aimed to optimize osseointegration through anodization in dental implants, obtaining anatase phase and controlled nanotopography. Methods: The division of...

  • Article
  • Open Access
120 Citations
7,587 Views
14 Pages

The Effect of Bottom Profile Dimples on the Femoral Head on Wear in Metal-on-Metal Total Hip Arthroplasty

  • J. Jamari,
  • Muhammad Imam Ammarullah,
  • Amir Putra Md Saad,
  • Ardiyansyah Syahrom,
  • Mohammad Uddin,
  • Emile van der Heide and
  • Hasan Basri

Wear and wear-induced debris is a significant factor in causing failure in implants. Reducing contact pressure by using a textured surface between the femoral head and acetabular cup is crucial to improving the implant’s life. This study presented th...

  • Article
  • Open Access
29 Citations
6,049 Views
17 Pages

Physico-Chemical Properties and Biocompatibility of Thermosensitive Chitosan Lactate and Chitosan Chloride Hydrogels Developed for Tissue Engineering Application

  • Katarzyna Pieklarz,
  • Grzegorz Galita,
  • Michał Tylman,
  • Waldemar Maniukiewicz,
  • Ewa Kucharska,
  • Ireneusz Majsterek and
  • Zofia Modrzejewska

Recently, the modification of the initial structure of biopolymers, mainly chitosan, has been gaining importance with a view to obtain functional forms with increased practicality and specific properties enabling their use in tissue engineering. Ther...

  • Article
  • Open Access
9 Citations
4,408 Views
15 Pages

TiAl6V4 Alloy Surface Modifications and Their Impact on Biofilm Development of S. aureus and S. epidermidis

  • Astrid H. Paulitsch-Fuchs,
  • Lukas Wolrab,
  • Nicole Eck,
  • Nigel P. Dyer,
  • Benjamin Bödendorfer and
  • Birgit Lohberger

One of the most serious complications following joint replacement surgeries are periprosthetic infections (PIs) arising from the adhesion of bacteria to the artificial joint. Various types of titanium–aluminum–vanadium (TiAl6V4) alloy surface modific...

  • Article
  • Open Access
11 Citations
4,646 Views
8 Pages

Single tooth implant restorations in the aesthetic area are a demanding challenge. If a complete osseointegration is mandatory, the final result has to result in a higher standard of biomimetic and soft tissue health among natural teeth. This outcome...

  • Article
  • Open Access
22 Citations
4,593 Views
18 Pages

EtoGel for Intra-Articular Drug Delivery: A New Challenge for Joint Diseases Treatment

  • Maria Chiara Cristiano,
  • Antonia Mancuso,
  • Elena Giuliano,
  • Donato Cosco,
  • Donatella Paolino and
  • Massimo Fresta

Ethosomes® have been proposed as potential intra-articular drug delivery devices, in order to obtain a longer residence time of the delivered drug in the knee joint. To this aim, the conventional composition and preparation method were modified. Etho...

  • Article
  • Open Access
9 Citations
3,523 Views
10 Pages

Endothelial Cell Responses to a Highly Deformable Titanium Alloy Designed for Vascular Stent Applications

  • Raluca Ion,
  • Gaëtan Cabon,
  • Doina-Margareta Gordin,
  • Elena Ionica,
  • Thierry Gloriant and
  • Anisoara Cimpean

Titanium alloys are widely used for biomedical applications due to their good biocompatibility. Nevertheless, they cannot be used for balloon expandable stents due to a lack of ductility compared to cobalt-chromium (Co-Cr) alloys and stainless steels...

  • Feature Paper
  • Article
  • Open Access
11 Citations
3,528 Views
17 Pages

β-d-N-acetyl-hexosaminidase (Hex, EC 3.2.1.52) is an acid hydrolase that catalyzes the cleavage of the β-1,4 bond in N-acetyl-d-galactosamine (Gal-NAc) and N-acetyl-d-glucosamine (Glc-NAc) from the non-reducing end of oligosaccharides and glycoconjug...

  • Article
  • Open Access
10 Citations
4,069 Views
27 Pages

Oral diseases and periodontitis in particular are a major health burden worldwide, because of their association with various systemic diseases and with conditions such as peri-implantitis. Attempts have been made over the years to reverse bone loss d...

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J. Funct. Biomater. - ISSN 2079-4983