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Article

TiAl6V4 Alloy Surface Modifications and Their Impact on Biofilm Development of S. aureus and S. epidermidis

1
Biomedical Sciences, University of Applied Sciences Carinthia, 9020 Klagenfurt, Austria
2
Diagnostic and Research Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, 8010 Graz, Austria
3
Department of Orthopaedics and Trauma, Medical University of Graz, 8036 Graz, Austria
4
Bioinformatics Research Technology Platform, University of Warwick, Coventry CV4 7AL, UK
*
Author to whom correspondence should be addressed.
Academic Editor: John H. T. Luong
J. Funct. Biomater. 2021, 12(2), 36; https://doi.org/10.3390/jfb12020036
Received: 20 April 2021 / Revised: 11 May 2021 / Accepted: 12 May 2021 / Published: 18 May 2021
One of the most serious complications following joint replacement surgeries are periprosthetic infections (PIs) arising from the adhesion of bacteria to the artificial joint. Various types of titanium–aluminum–vanadium (TiAl6V4) alloy surface modifications (coatings with silver (Ag), titanium nitride (TiN), pure titanium (cpTi), combinations of cpTi and hydroxyapatite (HA), combinations of cpTi and tricalcium phosphate (TCP), and a rough-blasted surface of TiAl6V4) have been investigated to assess their effects on biofilm development. Biofilms were grown, collected, and analyzed after 48 h to measure their protein and glucose content and the cell viability. Biofilm-associated genes were also monitored after 48 h of development. There was a distinct difference in the development of staphylococcal biofilms on the surfaces of the different types of alloy. According to the findings of this study, the base alloy TiAl6V4 and the TiN-coated surface are the most promising materials for biofilm reduction. Rough surfaces are most favorable when it comes to bacterial infections because they allow an easy attachment of pathogenic organisms. Of all rough surfaces tested, rough-blasted TiAl6V4 was the most favorable as an implantation material; all the other rough surfaces showed more distinct signs of inducing the development of biofilms which displayed higher protein and polysaccharide contents. These results are supported by RT-qPCR measurements of biofilm associated genes for Staphylococcus aureus (icaA, icaC, fnbA, fnbB, clfB, atl) and Staphylococcus epidermidis (atle, aap). View Full-Text
Keywords: Staphylococcus aureus; Staphylococcus epidermidis; biofilms; titanium alloys; prosthetic infections Staphylococcus aureus; Staphylococcus epidermidis; biofilms; titanium alloys; prosthetic infections
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MDPI and ACS Style

Paulitsch-Fuchs, A.H.; Wolrab, L.; Eck, N.; Dyer, N.P.; Bödendorfer, B.; Lohberger, B. TiAl6V4 Alloy Surface Modifications and Their Impact on Biofilm Development of S. aureus and S. epidermidis. J. Funct. Biomater. 2021, 12, 36. https://doi.org/10.3390/jfb12020036

AMA Style

Paulitsch-Fuchs AH, Wolrab L, Eck N, Dyer NP, Bödendorfer B, Lohberger B. TiAl6V4 Alloy Surface Modifications and Their Impact on Biofilm Development of S. aureus and S. epidermidis. Journal of Functional Biomaterials. 2021; 12(2):36. https://doi.org/10.3390/jfb12020036

Chicago/Turabian Style

Paulitsch-Fuchs, Astrid H., Lukas Wolrab, Nicole Eck, Nigel P. Dyer, Benjamin Bödendorfer, and Birgit Lohberger. 2021. "TiAl6V4 Alloy Surface Modifications and Their Impact on Biofilm Development of S. aureus and S. epidermidis" Journal of Functional Biomaterials 12, no. 2: 36. https://doi.org/10.3390/jfb12020036

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