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Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

Council for Agricultural Research and Economics. Rome 00185, Italy
Department of Agriculture, University Federico II of Naples, Via Università 100, Portici 80055, Italy
Department of Environmental Biological and Pharmaceutical Sciences and Technologies, Second University of Naples, Via Vivaldi 43, Caserta 81100, Italy
Author to whom correspondence should be addressed.
Academic Editor: Anna Andolfi
Agriculture 2015, 5(4), 918-970;
Received: 13 May 2015 / Revised: 17 September 2015 / Accepted: 21 September 2015 / Published: 29 September 2015
(This article belongs to the Special Issue Phytotoxic Fungal Metabolites)
PDF [452 KB, uploaded 29 September 2015]


It is known that plant-based ethnomedicine represented the foundation of modern pharmacology and that many pharmaceuticals are derived from compounds occurring in plant extracts. This track still stimulates a worldwide investigational activity aimed at identifying novel bioactive products of plant origin. However, the discovery that endophytic fungi are able to produce many plant-derived drugs has disclosed new horizons for their availability and production on a large scale by the pharmaceutical industry. In fact, following the path traced by the blockbuster drug taxol, an increasing number of valuable compounds originally characterized as secondary metabolites of plant species belonging to the Spermatophyta have been reported as fermentation products of endophytic fungal strains. Aspects concerning sources and bioactive properties of these compounds are reviewed in this paper. View Full-Text
Keywords: plant-derived drugs; bioactive compounds; endophytic fungi plant-derived drugs; bioactive compounds; endophytic fungi

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Nicoletti, R.; Fiorentino, A. Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta. Agriculture 2015, 5, 918-970.

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