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Article

Pulmonary Embolism and Coexisting Deep Vein Thrombosis: A Detrimental Association?

1
Department of Hypertension, Vascular Disease and Clinical Pharmacology, Strasbourg Regional University Hospital, 67091 Strasbourg, France
2
UMR 1260 INSERM Nanomédecie Régénérative, Faculté de Pharmacie, Université de Strasbourg, 67401 Illkirch, France
3
Department of vascular surgery and vascular medicine, Reims University Hospital, 51100 Reims, France
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(6), 899; https://doi.org/10.3390/jcm8060899
Received: 24 May 2019 / Revised: 17 June 2019 / Accepted: 19 June 2019 / Published: 23 June 2019
(This article belongs to the Section Vascular Medicine)
Background: The prognostic significance of coexisting deep vein thrombosis (DVT) in acute pulmonary embolism (PE) is controversial. This study aimed to provide routine patient care data on the impact of this association on PE severity and 3-month outcomes in a population presenting with symptomatic venous thromboembolism (VTE) from the REMOTEV registry. Methods and Results: REMOTEV is a prospective, non-interventional study of patients with acute symptomatic VTE, treated with direct oral anticoagulants (DOACs) or standard anticoagulation (vitamin K antagonists (VKA) or parenteral heparin/fondaparinux alone) for at least 3 months. From 1 November 2013 to 28 February 2018, among 1241 consecutive patients included, 1192 had a follow-up of at least 3 months and, among them, 1037 had PE with (727) or without DVT (310). The median age was 69 (55–80, 25th–75th percentiles). Patients with PE-associated DVT had more severe forms of PE (p < 0.0001) and, when DVT was present, proximal location was significantly correlated to PE severity (p < 0.01). However, no difference in all-cause mortality rate (hazard ratio (HR) 1.36 (CI 95% 0.69–2.92)), nor in the composite criterion of all-cause mortality and recurrence rate (HR 1.56 (CI 95% 0.83–3.10)) was noted at 3 months of follow-up. Conclusion: In REMOTEV, coexisting DVT was associated with a higher severity of PE, with no impact on short-term prognosis. View Full-Text
Keywords: venous thromboembolism; deep vein thrombosis; pulmonary embolism; severity venous thromboembolism; deep vein thrombosis; pulmonary embolism; severity
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MDPI and ACS Style

Cordeanu, E.-M.; Lambach, H.; Heitz, M.; Di Cesare, J.; Mirea, C.; Faller, A.-M.; Cavaro, A.-C.; Frantz, A.-S.; Gaertner, S.; Schini-Kerth, V.; Stephan, D. Pulmonary Embolism and Coexisting Deep Vein Thrombosis: A Detrimental Association? J. Clin. Med. 2019, 8, 899. https://doi.org/10.3390/jcm8060899

AMA Style

Cordeanu E-M, Lambach H, Heitz M, Di Cesare J, Mirea C, Faller A-M, Cavaro A-C, Frantz A-S, Gaertner S, Schini-Kerth V, Stephan D. Pulmonary Embolism and Coexisting Deep Vein Thrombosis: A Detrimental Association? Journal of Clinical Medicine. 2019; 8(6):899. https://doi.org/10.3390/jcm8060899

Chicago/Turabian Style

Cordeanu, Elena-Mihaela, Hélène Lambach, Marie Heitz, Julie Di Cesare, Corina Mirea, Alix-Marie Faller, Anne-Cécile Cavaro, Anne-Sophie Frantz, Sebastien Gaertner, Valérie Schini-Kerth, and Dominique Stephan. 2019. "Pulmonary Embolism and Coexisting Deep Vein Thrombosis: A Detrimental Association?" Journal of Clinical Medicine 8, no. 6: 899. https://doi.org/10.3390/jcm8060899

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