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Journal of Clinical Medicine, Volume 14, Issue 9

May-1 2025 - 406 articles

Cover Story: This review examines acute cardiorenal syndrome (CRS) through a clinical lens, providing practical diagnostic and treatment strategies. It incorporates thoracic and venous excess ultrasound to assess congestion at the bedside and clarifies the clinical significance of rising serum creatinine during diuresis, distinguishing transient changes from true renal injury. It outlines a systematic approach to overcoming diuretic resistance, including natriuresis-guided sequential nephron blockade, ultrafiltration, and inotropic support. We also discuss emerging trials that address renal hypoperfusion and systemic venous congestion. This paper provides evidence-based guidance to support clinicians in making timely and effective decisions to improve patient outcomes in acute CRS. View this paper
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Articles (406)

  • Review
  • Open Access
1 Citations
2,360 Views
21 Pages

Postoperative infection following anterior cervical spine surgery, particularly when complicated by esophageal injury, is a rare but serious condition associated with significant morbidity and mortality. This review elucidates the complex interplay b...

  • Article
  • Open Access
779 Views
22 Pages

Comparison of Dimensional Accuracy of Diagnostic Trial Restoration Transfer with Four Different Methods: A Randomized Clinical Trial

  • Lucas Queiroz Caponi,
  • Pilar Fenoy-Illacer,
  • Oscar Figueras-Álvarez,
  • Eduardo de Lima Flor,
  • Carla Vidal-Ponsoda and
  • Miguel Roig

Background/Objective: Diagnostic trial restorations play a crucial role in restorative dentistry by allowing clinicians to evaluate aesthetics, function, and phonetics before finalizing definitive restorations. These restorations facilitate communica...

  • Article
  • Open Access
694 Views
11 Pages

Background/Objectives: To investigate the impact of pachychoroid on the clinical features of neovascular age-related macular degeneration (nAMD) in Japan using the deep learning-based Hokkaido University pachychoroid index (HUPI), which has a high di...

  • Article
  • Open Access
1 Citations
1,349 Views
9 Pages

Background/Objectives: Sepsis has a high mortality rate, with septic shock exceeding 50%. The most common score for diagnosis and prognosis in sepsis is the Sepsis-related Organ Failure Assessment (SOFA). This study aimed to identify hematological pa...

  • Article
  • Open Access
1,130 Views
13 Pages

A Multicenter Study by the DENO Research Group on the Use of Denosumab in Giant-Cell Tumors of the Bone

  • DENO Research Group,
  • Carolina de la Calva,
  • Manuel Angulo,
  • Paula González-Rojo,
  • Ana Peiró,
  • Pau Machado,
  • Juan Luis Cebrián,
  • Roberto García-Maroto,
  • Antonio Valcárcel and
  • Pablo Puertas
  • + 11 authors

Background/Objectives: Despite the therapeutic potential of denosumab for the treatment of giant-cell tumors of the bone (GCTBs), there is a lack of standardization in treatment protocols. Methods: We present a multicenter, retrospective, descriptive...

  • Article
  • Open Access
1 Citations
1,275 Views
10 Pages

Prevalence and Risk Factors of Metabolic-Associated Fatty Liver Disease in Children with Down Syndrome at a Tertiary Care Center

  • Maria D. Karaceper,
  • Maria-Jose Villegas,
  • Sanathan Sadh,
  • Sierra Kawesa,
  • Jamie Strain,
  • Asha Nair,
  • Alissa Dupuis,
  • Mary Pothos,
  • Ming-Hua Zheng and
  • Mohit Kehar

Background: The global rise of metabolic-associated fatty liver disease (MAFLD) in children is particularly concerning in high-risk groups such as those with Down Syndrome (DS), who have an elevated risk of obesity and insulin resistance. Despite inc...

  • Systematic Review
  • Open Access
1 Citations
6,108 Views
22 Pages

Oral Dydrogesterone Versus Vaginal Progesterone for Luteal Phase Support in Frozen–Thawed Embryo Transfer Cycles: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

  • Konstantinos Stavridis,
  • Dimitrios Balafoutas,
  • Theodoros Kalampokas,
  • Vassiliki Benetou,
  • Evangelia Samoli,
  • Nikolaos Vlahos and
  • Maria-Iosifina Kasdagli

Background/Objectives: Until recently, oral dydrogesterone has only been established in fresh in vitro fertilization (IVF) cycles, whereas its role in luteal phase support (LPS) for frozen embryo transfer (FET) cycles remains unclear. The aim of this...

  • Systematic Review
  • Open Access
5 Citations
7,854 Views
13 Pages

Reducing Infections and Improving Healing in Complex Wounds: A Systematic Review and Meta-Analysis

  • María Juana Millán-Reyes,
  • Diego Fernando Afanador-Restrepo,
  • María del Carmen Carcelén-Fraile,
  • Agustín Aibar-Almazán,
  • Marcelina Sánchez-Alcalá,
  • Javier Cano-Sánchez,
  • María Aurora Mesas-Aróstegui and
  • Yolanda Castellote-Caballero

Background and Objectives: Wound management in complex and traumatic injuries remains a significant clinical challenge, with a high risk of surgical site infections (SSIs) and associated complications. This systematic review and meta-analysis aim to...

  • Article
  • Open Access
2 Citations
1,903 Views
10 Pages

Introduction: The present study investigates the five-year outcomes of hip arthroscopy for cam or pincer-type femoroacetabular impingement (FAI) and associated labral tears in a defined patient population. Methods: Patients who underwent hip arthrosc...

  • Systematic Review
  • Open Access
985 Views
11 Pages

Matrix Metalloproteinase-9 and Postoperative Outcomes in Carotid Endarterectomy: A Systematic Review

  • João Gonçalves-Silva,
  • Mariana Fragão-Marques,
  • Hugo Ribeiro,
  • Susana I. Sá and
  • João Rocha-Neves

Background/Objectives: Carotid endarterectomy (CEA) is the treatment of choice for severe symptomatic and asymptomatic carotid artery stenosis. Nonetheless, it carries risks and several complications, including stroke and death. Previous studies have...

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J. Clin. Med. - ISSN 2077-0383