Intrapartum Maternal Fever and Long-Term Infectious Morbidity of the Offspring
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion and Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristic | Peripartum Fever (n = 538) | No Peripartum Fever (n = 355,818) | p-Value a |
---|---|---|---|
Maternal age at index birth (years ± SD) | 27.2 ± 5.5 | 28.3 ± 5.8 | <0.001 |
Primiparity (%) | 53.3 | 24.1 | <0.001 |
Maternal diabetes mellitus (%) | 5.9 | 4.8 | 0.201 |
Hypertensive disorders of pregnancy (%) b | 6.3 | 4.7 | 0.071 |
Pregnancy following fertility treatments (%) c | 3.2 | 1.7 | 0.007 |
Mean gestational age (weeks ± SD) | 38.4 ± 3.1 | 39.0 ± 2.0 | <0.001 |
Epidural labor analgesia | 43.1 | 19.6 | <0.001 |
Preterm delivery (<37 weeks, %) | 13.4 | 6.9 | <0.001 |
IUGR (%) d | 1.3 | 1.7 | 0.43 |
Oligohydramnios (%) | 3.5 | 2.2 | 0.036 |
Prelabor rupture of membranes (%) | 3.3 | 0.5 | <0.001 |
Induction of labor (%) | 45.7 | 21.2 | <0.001 |
Maternal GBS colonization (%) | 0.1 | 0.8 | 1.0 |
Non-reassuring fetal heart rate patterns (%) | 25.8 | 5.3 | <0.001 |
Meconium-stained amniotic fluid (%) | 24.7 | 12.0 | <0.001 |
Placental abruption (%) | 1.1 | 0.5 | 0.065 |
Prolonged second stage of labor (%) | 4.5 | 1.2 | <0.001 |
Cesarean delivery (%) | 36.4 | 14.0 | <0.001 |
Apgar score < 7 at 5 min (%) | 2.5 | 0.6 | <0.001 |
Birthweight (grams ± SD) | 3153.0 ± 649 | 3200.4 ± 519 | 0.09 |
Cord blood pH < 7.0 (%) | 6.7% | 0.4% | 0.059 |
Low birth weight ≤ 2500 g (%) | 10.0 | 6.9 | 0.004 |
Very low birth weight ≤ 1500 g (%) | 3.3 | 0.8 | <0.001 |
SGA (%) e | 2.0 | 4.6 | 0.05 |
Perinatal mortality (%) | 2.8 | 0.8 | <0.001 |
Infectious Condition | Peripartum Fever (n = 538) | No Peripartum Fever (n = 355,818) | p-Value |
---|---|---|---|
Bacterial infections (%) | 2.0 | 1.5 | 0.26 |
Viral infections (%) | 5.2 | 3.2 | 0.009 |
Fungal infections (%) | 0.4 | 0.1 | 0.045 |
CNS infections a (%) | 0.7 | 0.5 | 0.37 |
ENT infections b (%) | 8.6 | 6.4 | 0.044 |
Respiratory infections (%) | 16.5 | 13.8 | 0.067 |
Gastrointestinal infections (%) | 4.3 | 3.0 | 0.07 |
Total hospitalizations (%) | 30.1 | 24.1 | 0.001 |
Characteristic | HR | 95% CI | p-Value |
---|---|---|---|
Maternal fever | 1.21 | 1.04–1.41 | 0.016 |
Gestational age (weeks) | 0.95 | 0.94–0.95 | <0.001 |
Maternal age at birth | 0.99 | 0.98–1.0 | <0.001 |
Maternal diabetes mellitus a | 1.07 | 1.04–1.11 | <0.001 |
Hypertensive disorders of pregnancy b | 1.04 | 1.01–1.07 | 0.02 |
Maternal GBS d colonization | 1.21 | 1.12–1.32 | <0.001 |
Non-reassuring fetal heart rate patterns | 1.04 | 1.01–1.07 | 0.008 |
Cesarean delivery | 1.11 | 1.09–1.13 | <0.001 |
Very low birth weight ≤ 1500 g | 0.59 | 0.54–0.65 | <0.001 |
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Zamstein, O.; Wainstock, T.; Sheiner, E. Intrapartum Maternal Fever and Long-Term Infectious Morbidity of the Offspring. J. Clin. Med. 2023, 12, 3329. https://doi.org/10.3390/jcm12093329
Zamstein O, Wainstock T, Sheiner E. Intrapartum Maternal Fever and Long-Term Infectious Morbidity of the Offspring. Journal of Clinical Medicine. 2023; 12(9):3329. https://doi.org/10.3390/jcm12093329
Chicago/Turabian StyleZamstein, Omri, Tamar Wainstock, and Eyal Sheiner. 2023. "Intrapartum Maternal Fever and Long-Term Infectious Morbidity of the Offspring" Journal of Clinical Medicine 12, no. 9: 3329. https://doi.org/10.3390/jcm12093329
APA StyleZamstein, O., Wainstock, T., & Sheiner, E. (2023). Intrapartum Maternal Fever and Long-Term Infectious Morbidity of the Offspring. Journal of Clinical Medicine, 12(9), 3329. https://doi.org/10.3390/jcm12093329