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Journal of Clinical Medicine, Volume 12, Issue 20

October-2 2023 - 272 articles

Cover Story: Cardiovascular diseases are the major cause of death in the Western world. Since current risk stratification systems fail to identify all subjects at high risk, there is an unmet need for more precise risk assessment. P-selectin plays an important role in the pathogenesis of atherosclerosis by mediating leukocyte rolling along the vessel wall. A secreted form, soluble P-selectin, circulates in plasma and has been proposed as a cardiovascular biomarker. Peripheral atherosclerosis can be quantified by measuring the plaque volume in the carotid and femoral artery using three-dimensional ultrasound. The progression of plaque volume is paralleled by increasing soluble P-selectin plasma levels. The inclusion of serial measurements of P-selectin into prediction scores like the ESC-SCORE has the potential to further improve risk stratification. View this paper
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Articles (272)

  • Review
  • Open Access
30 Citations
9,731 Views
12 Pages

23 October 2023

Janus kinase inhibitors (JAKis) are the most recent new drug class to arrive to the market for rheumatoid arthritis (RA) treatment. While they have proven to be a very effective treatment option, there remains significant concern regarding the risk o...

  • Article
  • Open Access
7 Citations
2,089 Views
11 Pages

Effect of Nonsurgical Periodontal Treatment on Salivary and Plasma Superoxide Dismutase Levels of Patients Suffering from Periodontitis

  • Tanja Veljovic,
  • Milanko Djuric,
  • Jelena Mirnic,
  • Ivana Gusic,
  • Aleksandra Maletin,
  • Stojan Ivic,
  • Marija Stojilkovic and
  • Snezana Brkic

23 October 2023

Antioxidant capacity is frequently measured by evaluating superoxide dismutase (SOD) concentration in body fluids. The aim of this study was to compare SOD concentrations in the saliva and plasma of patients with periodontitis to those measured in a...

  • Article
  • Open Access
2 Citations
2,371 Views
11 Pages

Diabetes-Related Mortality in a Developing Country: An Exploration of Tertiary Hospital Data

  • Yanjmaa Sankhuu,
  • Odgarig Altaisaikhan,
  • Munkh-Od Battsogt,
  • Oyuntugs Byambasukh and
  • Altaisaikhan Khasag

23 October 2023

(1) Background: Given the growing global diabetes crisis, this study examined the causes of mortality in diabetic patients at a Mongolian tertiary care hospital. (2) Between 2017 and 2021, data from 100 individuals with diabetes (53% male, mean age 5...

  • Article
  • Open Access
2 Citations
3,072 Views
12 Pages

23 October 2023

Background: Reduced-dose rivaroxaban (10 mg) was used in the J-ROCKET AF trial, demonstrating safety in the Asian population. It remains unclear whether treatment with reduced-dose versus full-dose rivaroxaban (20 mg/15 mg) is associated with all-cau...

  • Review
  • Open Access
7 Citations
18,930 Views
17 Pages

High-Flow Oxygen Therapy in the Perioperative Setting and Procedural Sedation: A Review of Current Evidence

  • Lou’i Al-Husinat,
  • Basil Jouryyeh,
  • Ahlam Rawashdeh,
  • Abdelrahman Alenaizat,
  • Mohammad Abushehab,
  • Mohammad Wasfi Amir,
  • Zaid Al Modanat,
  • Denise Battaglini and
  • Gilda Cinnella

23 October 2023

High-flow oxygen therapy (HFOT) is a respiratory support system, through which high flows of humidified and heated gas are delivered to hypoxemic patients. Several mechanisms explain how HFOT improves arterial blood gases and enhances patients’...

  • Article
  • Open Access
4 Citations
4,490 Views
15 Pages

23 October 2023

Background: Presently, the management of patients with maxilla bone defects of the Cawood V or VI class is achieved using zygomatic or individual implants or through augmentation of the bone. For zygomatic implants, the ORIS criteria represent the mo...

  • Article
  • Open Access
2 Citations
1,546 Views
12 Pages

23 October 2023

The objective of this study was to investigate the variables associated with multimorbidity status among older United States (US) adults with self-reported pain and opioid use. This study used a cross-sectional retrospective database design that incl...

  • Article
  • Open Access
6 Citations
2,679 Views
21 Pages

Celecoxib Suppresses NF-κB p65 (RelA) and TNFα Expression Signaling in Glioblastoma

  • Hina Ahsan,
  • Shaukat Iqbal Malik,
  • Fawad Ali Shah,
  • Hamed A. El-Serehy,
  • Amin Ullah and
  • Zafar Abbas Shah

23 October 2023

Background: Glioblastoma (GBM) harbors significant genetic heterogeneity, high infiltrative capacity, and patterns of relapse following many therapies. The expression of nuclear factor kappa-B (NF-κB p65 (RelA)) and signaling pathways is consti...

  • Article
  • Open Access
1 Citations
2,364 Views
10 Pages

Safety of Pneumatic Dilation in Older Adults with Achalasia: An International Multicenter Cross-Sectional Study

  • Nir Bar,
  • Christopher Vélez,
  • Trisha S. Pasricha,
  • Tamar Thurm,
  • Dana Ben-Ami Shor,
  • Roy Dekel,
  • Yishai Ron,
  • Kyle Staller and
  • Braden Kuo

23 October 2023

Background: Pneumatic dilation (PD) is an effective first line treatment option for many patients with achalasia. PD use may be limited in adults with achalasia who are older than 65 because of concern for adverse events (AE), and less efficacious th...

  • Feature Paper
  • Review
  • Open Access
5 Citations
3,970 Views
12 Pages

23 October 2023

Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by immune dysregulation and progressive fibrosis, typically affecting the skin, with variable internal organ involvement. Interstitial lung disease (ILD), with a preval...

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J. Clin. Med. - ISSN 2077-0383