Expression of Iron Metabolism Proteins in Patients with Chronic Heart Failure

Kozłowska, Bogna; Sochanowicz, Barbara; Kraj, Leszek; Palusińska, Małgorzata; Kołsut, Piotr; Szymański, Łukasz; Lewicki, Sławomir; Śmigielski, Witold; Kruszewski, Marcin; Leszek, Przemysław

doi:10.3390/jcm11030837

Open AccessArticle

Expression of Iron Metabolism Proteins in Patients with Chronic Heart Failure

by

Bogna Kozłowska

¹,

Barbara Sochanowicz

²,

Leszek Kraj

^3,4,

Małgorzata Palusińska

⁴

,

Piotr Kołsut

⁵,

Łukasz Szymański

⁴

,

Sławomir Lewicki

^4,6

,

Witold Śmigielski

⁷,

Marcin Kruszewski

^2,8 and

Przemysław Leszek

^1,*

¹

Department of Heart Failure and Transplantology, The Cardinal Stefan Wyszyński National Institute of Cardiology, Alpejska 42, 04-628 Warsaw, Poland

²

Centre of Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warszawa, Poland

³

Department of Oncology, Medical University of Warsaw, 01-163 Warsaw, Poland

⁴

Department of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Science, Postępu 36A, 05-552 Magdalenka, Poland

⁵

Department of Cardiac Surgery and Transplantology, The Cardinal Stefan Wyszyński National Institute of Cardiology, Alpejska 42, 04-628 Warsaw, Poland

⁶

Faculty of Medical Sciences and Health Sciences, Kazimierz Pulaski University of Technology and Humanities, 26-600 Radom, Poland

⁷

Department of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, The Cardinal Stefan Wyszyński National Institute of Cardiology, Alpejska 42, 04-628 Warsaw, Poland

⁸

Department of Molecular Biology and Translational Research, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland

^*

Author to whom correspondence should be addressed.

J. Clin. Med. 2022, 11(3), 837; https://doi.org/10.3390/jcm11030837

Submission received: 14 December 2021 / Revised: 28 January 2022 / Accepted: 3 February 2022 / Published: 5 February 2022

(This article belongs to the Special Issue Iron Deficiency in Patients with Heart Failure: New Advances in Translational and Clinical Research)

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Abstract

In heart failure, iron deficiency is a common comorbid disease that negatively influences exercise tolerance, number of hospitalizations and mortality rate, and this is why iron iv supplementation is recommended. Little is known about the changes in iron-related proteins in the human HF myocardium. The purpose of this study was to assess iron-related proteins in non-failing (NFH) vs. failing (FH) human myocardium. The study group consisted of 58 explanted FHs; control consisted of 31 NFHs unsuitable for transplantation. Myocardial proteins expressions: divalent metal transporter (DMT-1); L-type calcium channel (L-CH); transferrin receptors (TfR-1/TfR-2); ferritins: heavy (FT-H) or light (FT-L) chain, mitochondrial (FT-MT); ferroportin (FPN), regulatory factors and oxidative stress marker: 4-hydroxynonenal (4-HNE). In FH, the expression in almost all proteins responsible for iron transport: DMT-1, TfR-1, L-CH, except TfR-2, and storage: FT-H/-L/-MT were reduced, with no changes in FPN. Moreover, 4-HNE expression (pg/mg; NFH 10.6 ± 8.4 vs. FH 55.7 ± 33.7; p < 0.0001) in FH was increased. HNE-4 significantly correlated with DMT-1 (r = −0.377, p = 0.036), L-CH (r = −0.571, p = 0.001), FT-H (r = −0.379, p = 0.036), also FPN (r = 0.422, p = 0.018). Reducing iron-gathering proteins and elevated oxidative stress in failing hearts is very unfavorable for myocardiocytes. It should be taken into consideration before treatment with drugs or supplements that elevate free oxygen radicals in the heart.

Keywords: heart failure; myocardial iron metabolism; oxidative stress; myocardial gathering proteins expression; human model

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MDPI and ACS Style

Kozłowska, B.; Sochanowicz, B.; Kraj, L.; Palusińska, M.; Kołsut, P.; Szymański, Ł.; Lewicki, S.; Śmigielski, W.; Kruszewski, M.; Leszek, P. Expression of Iron Metabolism Proteins in Patients with Chronic Heart Failure. J. Clin. Med. 2022, 11, 837. https://doi.org/10.3390/jcm11030837

AMA Style

Kozłowska B, Sochanowicz B, Kraj L, Palusińska M, Kołsut P, Szymański Ł, Lewicki S, Śmigielski W, Kruszewski M, Leszek P. Expression of Iron Metabolism Proteins in Patients with Chronic Heart Failure. Journal of Clinical Medicine. 2022; 11(3):837. https://doi.org/10.3390/jcm11030837

Chicago/Turabian Style

Kozłowska, Bogna, Barbara Sochanowicz, Leszek Kraj, Małgorzata Palusińska, Piotr Kołsut, Łukasz Szymański, Sławomir Lewicki, Witold Śmigielski, Marcin Kruszewski, and Przemysław Leszek. 2022. "Expression of Iron Metabolism Proteins in Patients with Chronic Heart Failure" Journal of Clinical Medicine 11, no. 3: 837. https://doi.org/10.3390/jcm11030837

APA Style

Kozłowska, B., Sochanowicz, B., Kraj, L., Palusińska, M., Kołsut, P., Szymański, Ł., Lewicki, S., Śmigielski, W., Kruszewski, M., & Leszek, P. (2022). Expression of Iron Metabolism Proteins in Patients with Chronic Heart Failure. Journal of Clinical Medicine, 11(3), 837. https://doi.org/10.3390/jcm11030837

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Expression of Iron Metabolism Proteins in Patients with Chronic Heart Failure

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