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Journal of Clinical Medicine, Volume 11, Issue 18

September-2 2022 - 240 articles

Cover Story: Acute idiopathic blind spot enlargement syndrome (AIBSES) predominantly affects young adults and is often misdiagnosed as optic neuritis because of low awareness. Only around 100 cases have been published. A careful taking of history and unprejudiced ophthalmological workup help in diagnosing AIBSES in patients with unilateral visual field loss in the blind spot area, acute onset photopsia, and funduscopically few or no optic disc changes. As it is a disease of the outer retina, optical coherence tomography (OCT) has become the gold standard in diagnosing AIBSES. In our case series, we present three consecutive patients with AIBSES that are followed prospectively with and without steroid therapy. All of the patients reported full recovery of their symptoms and partial restoration of the outer retinal layer anatomy. View this paper
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Articles (240)

  • Article
  • Open Access
3 Citations
2,058 Views
9 Pages

A Program to Reduce Post-Operative Opioid Prescribing at a Veteran’s Affairs Hospital

  • Callie Hlavin,
  • Sruthi Muluk,
  • Visala Muluk,
  • John Ryan,
  • Jeffrey Wagner and
  • Rajeev Dhupar

16 September 2022

Variability in surgeon prescribing patterns is common in the post-operative period and can be the nidus for dependence and addiction. This project aims to reduce opioid overprescribing at the Veteran’s Affairs Pittsburgh Healthcare System (VAPH...

  • Article
  • Open Access
3 Citations
2,112 Views
9 Pages

Functional Investigation of the Tumoural Heterogeneity of Intrahepatic Cholangiocarcinoma by In Vivo PET-CT Navigation: A Proof-of-Concept Study

  • Luca Viganò,
  • Egesta Lopci,
  • Luca Di Tommaso,
  • Annarita Destro,
  • Alessio Aghemo,
  • Lorenza Rimassa,
  • Luigi Solbiati,
  • Arturo Chiti,
  • Guido Torzilli and
  • Francesco Fiz

16 September 2022

Intra-tumoural heterogeneity (IH) is a major determinant of resistance to therapy and outcomes but remains poorly translated into clinical practice. Intrahepatic cholangiocarcinoma (ICC) often presents as large heterogeneous masses at imaging. The pr...

  • Article
  • Open Access
34 Citations
32,589 Views
17 Pages

Detection of Lumbar Spondylolisthesis from X-ray Images Using Deep Learning Network

  • Giam Minh Trinh,
  • Hao-Chiang Shao,
  • Kevin Li-Chun Hsieh,
  • Ching-Yu Lee,
  • Hsiao-Wei Liu,
  • Chen-Wei Lai,
  • Sen-Yi Chou,
  • Pei-I Tsai,
  • Kuan-Jen Chen and
  • Fang-Chieh Chang
  • + 2 authors

16 September 2022

Spondylolisthesis refers to the displacement of a vertebral body relative to the vertrabra below it, which can cause radicular symptoms, back pain or leg pain. It usually occurs in the lower lumbar spine, especially in women over the age of 60. The p...

  • Article
  • Open Access
7 Citations
2,162 Views
13 Pages

Multimorbidity and Frailty Are the Key Characteristics of Patients Hospitalized with COVID-19 Breakthrough Infection during Delta Variant Predominance in Italy: A Retrospective Study

  • Andrea Ticinesi,
  • Alberto Parise,
  • Nicoletta Cerundolo,
  • Antonio Nouvenne,
  • Beatrice Prati,
  • Giulia Chiussi,
  • Angela Guerra and
  • Tiziana Meschi

16 September 2022

The aims of this study were to describe the characteristics of patients hospitalized with delta SARS-CoV-2 breakthrough infection, and to identify factors associated with pneumonia on chest Computed Tomography (CT) and mortality. The clinical records...

  • Article
  • Open Access
7 Citations
2,533 Views
11 Pages

16 September 2022

Background: Chronic otitis media is a major public health burden that can result in a disabling hearing loss. Bone conduction hearing implants are an accepted form of hearing rehabilitation in these patients, but evidence supporting their usage typic...

  • Article
  • Open Access
3 Citations
1,921 Views
10 Pages

16 September 2022

An abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta greater than 50% of the diameter of a healthy aorta. Previous experimental studies confirm the effect of calprotectin (CAL) on the onset of arterial pathology. It has been sugg...

  • Article
  • Open Access
6 Citations
2,923 Views
14 Pages

Downregulation of Mannose-6-Phosphate Receptors in Fabry Disease Cardiomyopathy: A Potential Target for Enzyme Therapy Enhancement

  • Andrea Frustaci,
  • Romina Verardo,
  • Rossella Scialla,
  • Giulia Bagnato,
  • Margherita Verardo,
  • Maria Alfarano and
  • Matteo A. Russo

16 September 2022

Background: The efficacy of enzyme replacement therapy (ERT) in mobilizing globotryaosylceramide (GB-3) from Fabry cardiomyocytes is limited. The mechanism involved is still obscure. Methods: Assessment of M6Pr, M6Pr-mRNA, and Ubiquitin has been obta...

  • Article
  • Open Access
4 Citations
2,470 Views
8 Pages

Assessment of the Refractive Error and Stabilisation of Refraction after Cataract Surgery in Relation to the Length of the Eyeball

  • Małgorzata Mrugacz,
  • Mateusz Olszewski,
  • Magdalena Pony-Uram,
  • Jacek Brymerski and
  • Anna Bryl

16 September 2022

The aim of this study was to analyse the changes in refraction, depending on the length of the eyeball, in patients who had undergone cataract surgery using the phacoemulsification method and to assess the stability of refraction. A total of 90 patie...

  • Article
  • Open Access
23 Citations
2,328 Views
15 Pages

Circulating MicroRNAs Expression Profile in Lung Inflammation: A Preliminary Study

  • Davida Mirra,
  • Erika Cione,
  • Giuseppe Spaziano,
  • Renata Esposito,
  • Mario Sorgenti,
  • Elisabetta Granato,
  • Ida Cerqua,
  • Lucia Muraca,
  • Pasquale Iovino and
  • Luca Gallelli
  • + 1 author

16 September 2022

Background: Bronchial asthma is an inflammatory airway disease with an ever-increasing incidence. Therefore, innovative management strategies are urgently needed. MicroRNAs are small molecules that play a key role in lungs cellular functions and are...

  • Review
  • Open Access
18 Citations
4,521 Views
27 Pages

The Role of Silicone Oil in the Surgical Management of Endophthalmitis: A Systematic Review

  • Fabrizio Sinisi,
  • Marco Della Santina,
  • Pasquale Loiudice,
  • Michele Figus and
  • Giamberto Casini

16 September 2022

(1) Background: We aimed to systematically review the current literature to evaluate if in patients with postoperative endophthalmitis treated with pars plana vitrectomy, silicone oil tamponade could provide a useful contribution to the control and e...

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J. Clin. Med. - ISSN 2077-0383