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Journal of Clinical Medicine, Volume 10, Issue 3

February-1 2021 - 182 articles

Cover Story: Ventricular assist device (VAD)-specific infections, in particular, driveline infections, are a concerning complication of VAD implantation that often results in significant morbidity and even mortality. The presence of a percutaneous driveline at the skin exit-site and in the subcutaneous tunnel allows biofilm formation and migration by many bacterial and fungal pathogens. Biofilm formation is an important microbial strategy, providing a shield against antimicrobial treatment and human immune responses; biofilm migration facilitates the extension of infection to deeper tissues such as the pump pocket and the bloodstream. The purpose of this review is to improve the understanding of VAD-specific infections, from basic “bench” knowledge to clinical “bedside” experience, with a specific focus on the role of biofilms in driveline infections. View this paper
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Articles (182)

  • Review
  • Open Access
41 Citations
10,627 Views
13 Pages

2 February 2021

Postoperative parathyroid failure is the commonest adverse effect of total thyroidectomy, which is a widely used surgical procedure to treat both benign and malignant thyroid disorders. The present review focuses on the scientific gap and lack of dat...

  • Article
  • Open Access
17 Citations
3,989 Views
18 Pages

Unique Metabolomic Profile of Skeletal Muscle in Chronic Limb Threatening Ischemia

  • Ram B. Khattri,
  • Kyoungrae Kim,
  • Trace Thome,
  • Zachary R. Salyers,
  • Kerri A. O’Malley,
  • Scott A. Berceli,
  • Salvatore T. Scali and
  • Terence E. Ryan

2 February 2021

Chronic limb threatening ischemia (CLTI) is the most severe manifestation of peripheral atherosclerosis. Patients with CLTI have poor muscle quality and function and are at high risk for limb amputation and death. The objective of this study was to i...

  • Article
  • Open Access
13 Citations
4,464 Views
13 Pages

Multistate Modeling of COVID-19 Patients Using a Large Multicentric Prospective Cohort of Critically Ill Patients

  • Moreno Ursino,
  • Claire Dupuis,
  • Niccolò Buetti,
  • Etienne de Montmollin,
  • Lila Bouadma,
  • Dany Golgran-Toledano,
  • Stéphane Ruckly,
  • Mathilde Neuville,
  • Yves Cohen and
  • Bruno Mourvillier
  • + 9 authors

2 February 2021

The mortality of COVID-19 patients in the intensive care unit (ICU) is influenced by their state at admission. We aimed to model COVID-19 acute respiratory distress syndrome state transitions from ICU admission to day 60 outcome and to evaluate possi...

  • Article
  • Open Access
5 Citations
3,390 Views
13 Pages

Trends and Clinical Impact of Gastrointestinal Endoscopic Procedures on Acute Heart Failure in Spain (2002–2017)

  • Manuel Méndez-Bailón,
  • Rodrigo Jiménez-García,
  • Nuria Muñoz-Rivas,
  • Valentín Hernández-Barrera,
  • José Maria de Miguel-Yanes,
  • Javier de Miguel-Díez,
  • Emmanuel Andrès,
  • Noel Lorenzo-Villalba and
  • Ana López-de-Andrés

2 February 2021

Introduction: Heart failure decompensation can be triggered by many factors, including anemia. In cases of iron deficiency anemia or iron deficiency without anemia, endoscopic studies are recommended to rule out the presence of gastrointestinal neopl...

  • Article
  • Open Access
27 Citations
6,503 Views
13 Pages

Low-Intensity Resistance Training with Moderate Blood Flow Restriction Appears Safe and Increases Skeletal Muscle Strength and Size in Cardiovascular Surgery Patients: A Pilot Study

  • Hironaga Ogawa,
  • Toshiaki Nakajima,
  • Ikuko Shibasaki,
  • Takahisa Nasuno,
  • Hiroyuki Kaneda,
  • Satoshi Katayanagi,
  • Hayato Ishizaka,
  • Yuta Mizushima,
  • Azusa Uematsu and
  • Tomohiro Yasuda
  • + 6 authors

2 February 2021

We examined the safety and the effects of low-intensity resistance training (RT) with moderate blood flow restriction (KAATSU RT) on muscle strength and size in patients early after cardiac surgery. Cardiac patients (age 69.6 ± 12.6 years, n = 21, M...

  • Article
  • Open Access
2 Citations
3,725 Views
9 Pages

2 February 2021

(1) Background: During the COVID-19 pandemic, shortages in the supply of personal protective equipment (PPE) have become apparent. The idea of using commonly available full-face diving (FFD) masks as a temporary solution was quickly spread across soc...

  • Review
  • Open Access
25 Citations
4,454 Views
15 Pages

2 February 2021

Hepatitis C virus (HCV) is a major cause of death and morbidity globally and is a leading cause of hepatocellular carcinoma (HCC). Incidence of HCV infections, as well as HCV-related liver diseases, are increasing. Although now, with new direct actin...

  • Article
  • Open Access
12 Citations
9,808 Views
14 Pages

Development of a Single-Step Antibody–Drug Conjugate Purification Process with Membrane Chromatography

  • Juan Carlos Cordova,
  • Sheng Sun,
  • Jeffrey Bos,
  • Srinath Thirumalairajan,
  • Sanjeevani Ghone,
  • Miyako Hirai,
  • Ricarda A. Busse,
  • Julia S. v. der Hardt,
  • Ian Schwartz and
  • Jieyu Zhou

2 February 2021

Membrane chromatography is routinely used to remove host cell proteins, viral particles, and aggregates during antibody downstream processing. The application of membrane chromatography to the field of antibody-drug conjugates (ADCs) has been applied...

  • Article
  • Open Access
13 Citations
3,776 Views
9 Pages

2 February 2021

Assessing the harmful consequences of gambling is an area of active investigation. One measure intended to capture gambling-related harm is the 10-item short gambling harm screen (SGHS). Although good psychometric properties have been reported, it ha...

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J. Clin. Med. - ISSN 2077-0383