Special Issue "Cardiovascular Remodeling in Metabolic Disorders"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Endocrinology & Metabolism".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Dr. Elena Dozio
Guest Editor
Affiliation: Department of Biomedical Sciences for Health, Università degli Studi di Milano, Via L. Mangiagalli 31, 20133 Milan, Italy
Interests: obesity; metabolic disorders; biomarkers of cardiovascular diseases; advanced glycation end products

Special Issue Information

Dear Colleagues,

Cardiovascular remodeling is the response of specific cardiovascular cells (cardiomyocytes, endothelial, smooth muscle cells) as well as interstitial cells to different metabolic, hemodynamic, and inflammatory stimuli. Although the process is initially compensatory and functional, when damaging stimuli become chronic, it progresses to structural alterations that manifest clinically as change in size, mass, geometry, and functions of the heart and vessels.

Obesity is often associated with a clustering of cardiovascular risk factors that includes dyslipidemia, diabetes mellitus, inflammation, and hypertension. Alone or in association, these disorders typically predispose to an increased heart rate and stroke volume, which may lead to compensatory left ventricular remodeling, non-ischemic dilated cardiomyopathy, fibrosis, and apoptosis.

Despite novel therapeutic options, the prognosis of the affected patients remains poor. Therefore, understanding novel disease mechanisms, identifying disease biomarkers, and implementing imaging diagnostic tools can lead to early diagnosis and new therapeutic options for these patients.

This Special Issue entitled “Cardiovascular Remodeling in Metabolic Disorders” is open to basic, clinical, and translational original studies and review articles focused on exploring molecular mechanisms, diagnostic and prognostic tools, as well as new therapeutic approaches to improve the management of cardiovascular remodeling and clinical outcome of patients suffering from metabolic disorders such as obesity, diabetes mellitus, and dyslipidemia.

Dr. Elena Dozio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Cardiac and vascular remodeling
  • Cardiomyopathy
  • Fibrosis
  • Obesity
  • Diabetes
  • Dyslipidemia
  • Disease biomarkers
  • Diagnostic imaging
  • Therapies
  • Prognosis
  • Disease mechanisms

Published Papers

This special issue is now open for submission.
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