Cardiovascular Remodeling in Metabolic Disorders

Dear Colleagues,

Cardiovascular remodeling is the response of specific cardiovascular cells (cardiomyocytes, endothelial, smooth muscle cells) as well as interstitial cells to different metabolic, hemodynamic, and inflammatory stimuli. Although the process is initially compensatory and functional, when damaging stimuli become chronic, it progresses to structural alterations that manifest clinically as change in size, mass, geometry, and functions of the heart and vessels.

Obesity is often associated with a clustering of cardiovascular risk factors that includes dyslipidemia, diabetes mellitus, inflammation, and hypertension. Alone or in association, these disorders typically predispose to an increased heart rate and stroke volume, which may lead to compensatory left ventricular remodeling, non-ischemic dilated cardiomyopathy, fibrosis, and apoptosis.

Despite novel therapeutic options, the prognosis of the affected patients remains poor. Therefore, understanding novel disease mechanisms, identifying disease biomarkers, and implementing imaging diagnostic tools can lead to early diagnosis and new therapeutic options for these patients.

This Special Issue entitled “Cardiovascular Remodeling in Metabolic Disorders” is open to basic, clinical, and translational original studies and review articles focused on exploring molecular mechanisms, diagnostic and prognostic tools, as well as new therapeutic approaches to improve the management of cardiovascular remodeling and clinical outcome of patients suffering from metabolic disorders such as obesity, diabetes mellitus, and dyslipidemia.

Dr. Elena Dozio
Guest Editor

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