Membranes, Volume 12, Issue 9
2022 September - 86 articles
Cover Story: Cell membrane–drug interactions influence drugs’ in vivo behavior. However, these interactions are difficult to study due to the complexity of cell membranes. Lipid vesicles are non-complex tools that can be used to mimic membranes in physiological conditions. Thus, in this work, the interaction of an anticancer drug, bortezomib (BTZ), with cell membranes was evaluated using two models with distinct composition and complexity. The findings proved that the membrane’s complexity and composition are major factors influencing the BTZ–membrane interactions, which are mainly regulated by polar forces. Furthermore, these interactions were proven to induce changes in the membrane fluidity, which may promote its toxicity and facilitate drug efflux that mediates drug resistance. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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