Vaccines, Volume 11, Issue 5
2023 May - 132 articles
Cover Story: Tropical diseases caused by filarial nematodes such as lymphatic filariasis (elephantiasis) and onchocerciasis (river blindness) affect hundreds of millions of people worldwide. Despite decades of research, no vaccines against any filaria or helminths in general are available for use in human patients as of 2023. In this study by Scheunemann et al., the use of nucleic acid receptor agonists as potential vaccine adjuvants for filarial infections was evaluated in the Litomosoides sigmodontis rodent model. The authors reported that the use of poly(I:C), a TLR-3, MDA5, RIG-I ligand, and 3pRNA, a RIG-I ligand, improved the protective efficacy in comparison to the vaccination with irradiated L3 larvae alone and elicited stronger parasite-specific immune responses, highlighting the use of nucleic acid receptor agonists as promising vaccine strategies for filarial and other helminth infections. View this paper
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Vaccines - ISSN 2076-393X