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Paraoxonase 1, HDL Subclasses and Post Surgery Acute Inflammation: A Pilot Study

Glycation, Oxidation and Disease Lab, Research Department, Touro California College of Osteopathic Medicine, Vallejo, CA 94592, USA
Division of Community and Family Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-City, Tochigi 329-0498, Japan
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(6), 192;
Received: 25 May 2019 / Revised: 20 June 2019 / Accepted: 21 June 2019 / Published: 22 June 2019
(This article belongs to the Special Issue Paraoxonases in Oxidation and Inflammation)
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High density lipoproteins (HDL) structure and function studies are needed to better understand the heterogeneous nature of the HDL particle, and its interaction with associated proteins such as apolipoprotein A-1 (ApoA-1), paraoxonase 1 (PON1) and the environment. Our study assesses the effects of acute inflammation on PON1 and HDL subclasses in post-surgical colorectal cancer patients. PON1 was measured kinetically through its arylesterase and lactonase activity and HDL sub-classes were measured using Quantimetrix Lipoprint® System. White blood cells (WBC) counts, c-reactive protein (CRP) and serum amyloid A (SAA) levels were also analyzed using standard techniques. Our findings show that baseline PON1 activity is lower in colorectal cancer patients and significant reductions are observed in the acute inflammatory state post-surgery. PON1 changes are also inversely related to inflammatory markers such as SAA and CRP. In addition, our preliminary findings show that small and intermediate HDL decreases post-op Day 1. In conclusion, our study demonstrates the effects of chronic and acute inflammation on PON1. Specifically, PON1 arylesterase and lactonase activity is lower in states of chronic inflammation and further decreased in the acute inflammatory state. Additionally, in our limited sample size, while changes in PON1 and HDL subclasses may be variable in the acute inflammatory period, small HDL decreased with a loss of PON1 activity in the subacute phase. View Full-Text
Keywords: PON1; HDL subclasses; Acute inflammation; Chronic Inflammation; Colorectal Cancer; ApoA-1; CRP; SAA PON1; HDL subclasses; Acute inflammation; Chronic Inflammation; Colorectal Cancer; ApoA-1; CRP; SAA

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Bains, Y.; Caccavello, R.; Kotani, K.; Gugliucci, A. Paraoxonase 1, HDL Subclasses and Post Surgery Acute Inflammation: A Pilot Study. Antioxidants 2019, 8, 192.

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