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Polyphenols and IUGR Pregnancies: Effects of Maternal Hydroxytyrosol Supplementation on Postnatal Growth, Metabolism and Body Composition of the Offspring

1
Faculty of Veterinary Medicine, UCM, Ciudad Universitaria s/n. 28040 Madrid, Spain
2
SGIT-INIA, Ctra. de La Coruña Km. 7,5. 29040 Madrid, Spain
3
School of Veterinary Medicine and Zootechnics, Faculty of Agricultural Sciences, University of Cuenca, Avda. Doce de Octubre, 010220 Cuenca, Ecuador
4
Micros Veterinaria, Campus de Vegazana, 24007 Leon, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Antioxidants 2019, 8(11), 535; https://doi.org/10.3390/antiox8110535
Received: 4 October 2019 / Revised: 28 October 2019 / Accepted: 6 November 2019 / Published: 8 November 2019
Maternal supplementation with the polyphenol hydroxytyrosol in a swine model of intrauterine growth restriction (IUGR) improves the fetal oxidative status, decreases the appearance of low birth-weight neonates and favors growth during early postnatal stages (lactation). The current study aimed to determine whether hydroxytyrosol supplementation can also improve developmental patterns, metabolic traits, and body composition of the offspring during later postnatal stages (from weaning to adulthood). A total of 21 piglets born from control untreated sows and 20 piglets born from sows treated with hydroxytyrosol during the last two-thirds of pregnancy were selected on the basis of similar body weights at weaning, for avoiding any interfering effects occurred during lactation. The pigs in the treated group had higher average daily weight gain (ADWG) and, therefore, reached higher body weight and corpulence, greater muscle development and higher adiposity than their control counterparts. The following were not found: significant effects on metabolism and body composition except changes in the muscular fatty acid composition of the treated pigs coming from the largest litters; those more affected by IUGR processes. These findings suggest that maternal supplementation with hydroxytyrosol may improve juvenile development of offspring in at-risk pregnancies and pave the way for more specific studies aiming to elucidate effects on adiposity, metabolism, and meat organoleptic characteristics. View Full-Text
Keywords: antioxidants; intrauterine growth restriction; litter-size; pregnancy; swine model antioxidants; intrauterine growth restriction; litter-size; pregnancy; swine model
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Vazquez-Gomez, M.; Heras-Molina, A.; Garcia-Contreras, C.; Pesantez-Pacheco, J.L.; Torres-Rovira, L.; Martinez-Fernandez, B.; Gonzalez, J.; Encinas, T.; Astiz, S.; Ovilo, C.; Isabel, B.; Gonzalez-Bulnes, A. Polyphenols and IUGR Pregnancies: Effects of Maternal Hydroxytyrosol Supplementation on Postnatal Growth, Metabolism and Body Composition of the Offspring. Antioxidants 2019, 8, 535.

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