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Antioxidants, Volume 7, Issue 5 (May 2018)
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Cover Story (view full-size image) The philothion “glutathione” (GSH) was first discovered in yeast 130 years ago. GSH roles, from [...] Read more. The philothion “glutathione” (GSH) was first discovered in yeast 130 years ago. GSH roles, from reactive oxygen species scavenging to post-translational modifications of proteins, are related to its redox role and its cellular cycle. GSH depletion associated with oxidative stress occurs in the majority of diseases. A low bioavailability of GSH and its prodrugs leads to the development of glutathione delivery systems to replenish the stock. GSH is also being investigated as a molecular tool for targeted drug delivery to the brain or to the intracellular compartment. View Paper here.