Next Article in Journal
Anti-Oxidant and Anti-Inflammatory Activity of Ketogenic Diet: New Perspectives for Neuroprotection in Alzheimer’s Disease
Next Article in Special Issue
Inspired by Nature: Antioxidants and Nanotechnology
Previous Article in Journal
Fruit and Vegetable By-Products to Fortify Spreadable Cheese
Previous Article in Special Issue
Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Intoantimicrobial Materials
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessReview
Antioxidants 2018, 7(5), 62;

Glutathione: Antioxidant Properties Dedicated to Nanotechnologies

Université de Lorraine, CITHEFOR, F-54000 Nancy, France
Author to whom correspondence should be addressed.
Received: 28 March 2018 / Revised: 20 April 2018 / Accepted: 25 April 2018 / Published: 27 April 2018
(This article belongs to the Special Issue Inspired by Nature: Antioxidants and Nanotechnology)
Full-Text   |   PDF [2532 KB, uploaded 3 May 2018]   |  


Which scientist has never heard of glutathione (GSH)? This well-known low-molecular-weight tripeptide is perhaps the most famous natural antioxidant. However, the interest in GSH should not be restricted to its redox properties. This multidisciplinary review aims to bring out some lesser-known aspects of GSH, for example, as an emerging tool in nanotechnologies to achieve targeted drug delivery. After recalling the biochemistry of GSH, including its metabolism pathways and redox properties, its involvement in cellular redox homeostasis and signaling is described. Analytical methods for the dosage and localization of GSH or glutathiolated proteins are also covered. Finally, the various therapeutic strategies to replenish GSH stocks are discussed, in parallel with its use as an addressing molecule in drug delivery. View Full-Text
Keywords: glutathione; antioxidant; redox signaling; nanotechnologies; repletion; targeted drug delivery glutathione; antioxidant; redox signaling; nanotechnologies; repletion; targeted drug delivery

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Gaucher, C.; Boudier, A.; Bonetti, J.; Clarot, I.; Leroy, P.; Parent, M. Glutathione: Antioxidant Properties Dedicated to Nanotechnologies. Antioxidants 2018, 7, 62.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top