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Antioxidants 2018, 7(5), 62; https://doi.org/10.3390/antiox7050062

Glutathione: Antioxidant Properties Dedicated to Nanotechnologies

Université de Lorraine, CITHEFOR, F-54000 Nancy, France
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Received: 28 March 2018 / Revised: 20 April 2018 / Accepted: 25 April 2018 / Published: 27 April 2018
(This article belongs to the Special Issue Inspired by Nature: Antioxidants and Nanotechnology)
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Abstract

Which scientist has never heard of glutathione (GSH)? This well-known low-molecular-weight tripeptide is perhaps the most famous natural antioxidant. However, the interest in GSH should not be restricted to its redox properties. This multidisciplinary review aims to bring out some lesser-known aspects of GSH, for example, as an emerging tool in nanotechnologies to achieve targeted drug delivery. After recalling the biochemistry of GSH, including its metabolism pathways and redox properties, its involvement in cellular redox homeostasis and signaling is described. Analytical methods for the dosage and localization of GSH or glutathiolated proteins are also covered. Finally, the various therapeutic strategies to replenish GSH stocks are discussed, in parallel with its use as an addressing molecule in drug delivery. View Full-Text
Keywords: glutathione; antioxidant; redox signaling; nanotechnologies; repletion; targeted drug delivery glutathione; antioxidant; redox signaling; nanotechnologies; repletion; targeted drug delivery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Gaucher, C.; Boudier, A.; Bonetti, J.; Clarot, I.; Leroy, P.; Parent, M. Glutathione: Antioxidant Properties Dedicated to Nanotechnologies. Antioxidants 2018, 7, 62.

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