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Antioxidants, Volume 7, Issue 3 (March 2018)
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Cover Story (view full-size image) Lipophilic superoxide dismutase mimetics are effective mitigators of many disease processes that [...] Read more. Lipophilic superoxide dismutase mimetics are effective mitigators of many disease processes that involve oxidative injury. New data presented here demonstrate the development of a nonhuman primate model of radiation-induced lung injury, with high genetic and phenotypic similarity to human beings. The findings indicate the potential of MnTnHex-2-PyP5+ to mitigate radiation-induced lung injury. Both inflammation and pro-fibrotic mechanisms are involved, and further studies are needed to understand and maximize the mitigating effects. View this paper