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Antioxidants, Volume 14, Issue 2

February 2025 - 124 articles

Cover Story: Diabetic patients experience hyperglycemia, which can affect multiple organs, including brain function, leading to disabling neurological complications. Hyperglycemia plays a key role in promoting neuroinflammation, the most common complication in diabetic individuals, through the activation of microglia. Attenuating hyperglycemia-related neuroinflammation in microglia may reduce diabetes-associated neurological comorbidities. Natural remedies containing phenolic compounds have shown efficacy in mitigating microglia-mediated neuroinflammation. This study describes the efficacy of a Melissa officinalis L. phytocomplex, obtained from plant cell cultures and enriched in rosmarinic acid, in attenuating hyperglycemia-induced neuroinflammation in microglia and its potential neuroprotective action. View this paper
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Articles (124)

  • Article
  • Open Access
1 Citations
1,737 Views
16 Pages

Is High-Dose Ubiquinone Therapy Before Cardiac Surgery Enough to Reduce the Incidence of Cardiac Surgery-Associated Acute Kidney Injury? A Randomized Controlled Trial

  • Hrvoje Vučemilović,
  • Ruben Kovač,
  • Lada Stanišić,
  • Ana Sanader Vučemilović,
  • Dina Mrčela,
  • Benjamin Benzon and
  • Mladen Carev

19 February 2025

Cardiac surgery-related acute kidney injury (CS-AKI) is a decrease in kidney function after open-heart surgery, affecting up to 50% of patients. The pathophysiology of CS-AKI involves ischemia–reperfusion injury, inflammation, and oxidative str...

  • Article
  • Open Access
6 Citations
1,366 Views
20 Pages

19 February 2025

With global climate warming, enhancing the heat stress tolerance of rice seeds is critical for ensuring crop yields and maintaining global food security. 2,4-Epibrassionolide (EBR) has been shown to effectively alleviate the adverse effects of heat s...

  • Article
  • Open Access
2 Citations
1,678 Views
23 Pages

19 February 2025

In traditional Chinese medicine, the root bark and leaves of Schima argentea are utilized to treat dysentery, parasitic infections, and digestive disorders. In this study, the n-butanol extract of S. argentea (NBA) exhibited potent antioxidant proper...

  • Article
  • Open Access
1 Citations
1,244 Views
15 Pages

Unlocking Fertility: How Nitric Oxide Pathways Connect Obesity and Reproductive Health—The Role of Bariatric Surgery

  • Charalampos Voros,
  • Despoina Mavrogianni,
  • Kyriakos Bananis,
  • Antonia Varthaliti,
  • Anthi-Maria Papahliou,
  • Vasileios Topalis,
  • Panagiota Kondili,
  • Menelaos Darlas,
  • Maria Anastasia Daskalaki and
  • Agni Pantou
  • + 6 authors

19 February 2025

This study examines the relationship between obesity, oxidative stress, and reproductive dysfunction. It focuses on the effects of sleeve gastrectomy on gene expression and hormone profiles in 29 women with severe obesity (BMI ≥ 40 kg/m2). Pre- an...

  • Article
  • Open Access
4 Citations
1,524 Views
19 Pages

Genome-Wide Identification and Drought-Responsive Functional Analysis of the GST Gene Family in Potato (Solanum tuberosum L.)

  • Ningfan Shi,
  • Youfang Fan,
  • Wei Zhang,
  • Zhijia Zhang,
  • Zhuanfang Pu,
  • Zhongrun Li,
  • Lijun Hu,
  • Zhenzhen Bi,
  • Panfeng Yao and
  • Yuhui Liu
  • + 3 authors

19 February 2025

Glutathione S-transferases (GSTs) play crucial roles in crop stress tolerance through protection against oxidative damage. In this study, we conducted genome-wide identification and expression analysis of the GST gene family in the autotetraploid pot...

  • Review
  • Open Access
2 Citations
3,202 Views
16 Pages

Pharmacological Mechanism and Drug Research Prospects of Ginsenoside Rb1 as an Antidepressant

  • Shuhui Zhuang,
  • Fuqiang Shi,
  • Nazzareno Cannella,
  • Massimo Ubaldi,
  • Roberto Ciccocioppo,
  • Hongwu Li and
  • Di Qin

19 February 2025

This review explores the antidepressant effects of ginsenoside Rb1, a natural compound in traditional Chinese medicine, and its potential for treating major depressive disorder (MDD). The aetiology of depression was reviewed up to 2024, focusing on t...

  • Review
  • Open Access
9 Citations
3,201 Views
24 Pages

18 February 2025

Olive oil is widely recognized for its cancer-prevention properties, and its by-products, such as pomace and leaves, offer an opportunity for compound extraction. This study comprehensively reviews the antitumor activities of olive extracts and compo...

  • Article
  • Open Access
3 Citations
1,626 Views
14 Pages

Naringin Suppresses CoCl2-Induced Ferroptosis in ARPE-19 Cells

  • Yuchang Yang,
  • Manting Liu,
  • Xiaoxv Dong,
  • Jie Bai,
  • Wenjuan Shi,
  • Qian Zhu,
  • Juan Liu,
  • Ziheng Wang,
  • Lisa Yi and
  • Xingbin Yin
  • + 2 authors

18 February 2025

Hypoxic damage to retinal pigment epithelial (RPE) cells and subsequent neovascularization are key factors in the pathogenesis of branch retinal vein occlusion (BRVO). Naringin (NG), a naturally occurring flavanone glycoside, has demonstrated signifi...

  • Article
  • Open Access
1 Citations
1,851 Views
42 Pages

18 February 2025

Hydrogen peroxide (H2O2) plays a crucial role in cell signaling in response to physiological and environmental perturbations. H2O2 can oxidize typical 2-Cys peroxiredoxin (PRX) first into a sulfenic acid, which resolves into a disulfide that can be r...

  • Article
  • Open Access
974 Views
18 Pages

Deciphering Antioxidant Responses in Tomato Autografts

  • Carlos Frey,
  • Andrés Hernández-Barriuso,
  • José Luis Acebes and
  • Antonio Encina

18 February 2025

Grafting is a horticultural technique that involves a healing process that requires grafted plants to develop physiological responses to overcome oxidative stress. In this study, oxidative damage, total antioxidant capacity and antioxidant enzymatic...

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Antioxidants - ISSN 2076-3921