Oxidative Stress as a Crucial Factor in Liver Diseases: From Basic Research to Clinical Trials

Dear Colleagues,

Around the world, the incidence and prevalence of diseases affecting the liver have been increasing significantly. It should be noted that some of these diseases will gradually progress to cirrhosis and liver cancer, making it increasingly necessary to better understand the causes, pathophysiology, and prevention, as well as to study and propose new possible effective therapies. Some examples of liver diseases include non-alcoholic and alcoholic liver diseases, steatohepatitis, infectious hepatic diseases, metabolic and genetic diseases, drug or toxin liver failure, ischemia-reperfusion hepatic injury, autoimmune hepatitis, sepsis-related liver injury, liver fibrosis and cirrhosis, hepatocellular carcinoma, and others. The role of oxidative stress in liver dysfunction has been discussed for decades; a quick visit to the PubMed repository can offer an idea of the number of studies involving the combination of the terms “liver disease” and “oxidative stress”, just in the last 20 years. There is no doubt that laboratory, animal, and interventional studies with humans have been and continue to be indispensable and are therefore very welcome in this issue. Furthermore, the enormous amount of information already available in biological datasets makes it possible to integrate the different -omics sciences with relevant particularities of liver diseases and their outcomes; thus, in silico approaches employing bioinformatics tools will also be well received. I invite you to share, from bench to bed, your relevant results as well as your updated information in this Special Issue of the journal Antioxidants.

Prof. Dr. Fábio Rodrigues Ferreira Seiva
Guest Editor

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