Antioxidant Therapy for Cardiovascular Diseases
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 20737
Special Issue Editors
Interests: developing novel organelle-targeting strategies for precise delivery of bioimaging and therapeutic agents
Special Issues, Collections and Topics in MDPI journals
Interests: Professor Gibson’s research focus includes understanding the pathophysiology of selected disorders and developing novel pre-clinical treatment approaches with translational relevance.
Interests: diabetes; insulin; pancreatic beta cell; artificial pancreas system; glucose-insulin homeostasis
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Special Issue Information
Dear Colleagues,
Cardiovascular oxidative damage occurs when endogenous antioxidant levels are too insufficient to neutralize reactive oxygen species (ROS) and associated free radicals. ROS is associated with the pathophysiology of cardiovascular disorders, including cardiac hypertrophy, cardiomyopathy, heart failure, ventricular remodeling, and myocardial infarction. Due to its high energetic demand, the heart has the highest rate of production of ROS, yet in comparison to other mammalian organs, the heart has a significantly lower level of antioxidants and total antioxidant enzyme activities. It is widely agreed that ROS and oxidative damage are pathological components of cardiovascular diseases (CVDs). Historically, free radicals were merely considered toxins that induce oxidative stress and concomitant cellular damage, and for decades, considerable research has focused on approaches to eliminate excess free radicals generated in the body. Yet, experimental and clinical studies focused on the use of antioxidant therapy to mitigate myocardial damage have yielded mixed results. Moreover, decreasing the systemic level of ROS by using antioxidant therapy may in fact be detrimental in certain instances. Homeostatic mechanisms that maintain the balance between ROS generation and antioxidant production and consumption in CVD require fine tuning for optimal therapeutic outcomes. Our objectives in this Special Issue of Antioxidants are twofold: 1) to re-evaluate the utility and value of antioxidants in the prevention and treatment of CVD; 2) to highlight the expanding efficacy of naturally occurring antioxidants and synthetic antioxidants toward improvement of the functional and structural changes of CVD.
As Guest Editors, we invite you to contribute to the Special Issue on “Antioxidant Therapy for Cardiovascular Diseases”. Original research reports and reviews will be published online in Antioxidants.
Dr. Lanrong Bi
Prof. Dr. K. Michael Gibson
Prof. Dr. Guim Kwon
Guest Editors
Manuscript Submission Information
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Keywords
- Oxidative stress
- Free radicals
- Antioxidant
- Cardiovascular diseases
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