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Antioxidants, Volume 10, Issue 9

September 2021 - 173 articles

Cover Story: Sepsis, an exaggerated immune response upon infection, annually kills more than 10 million people. The major causative agent is bacterial lipopolysaccharide (LPS), and one of its first targets is the endothelium, the inner lining of all blood vessels, which reacts with activation and apoptosis. We have previously shown that an N-terminal peptide of the apurinic/apyrimidinic endodeoxyribonuclease 1 (APEX1) can inhibit apoptosis of endothelial cells (EC). In the current work, we demonstrate that expression of the endoplasmic reticulum resident selenoprotein T (SELENOT) is upregulated by LPS exclusively in EC expressing the APEX1 peptide. Moreover, SELENOT overexpression protects EC against LPS-induced activation and apoptosis. Thus, the APEX1 peptide or SELENOT could provide new therapeutic approaches in the treatment of sepsis. View this paper.
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Articles (173)

  • Article
  • Open Access
24 Citations
4,356 Views
20 Pages

Role of Oxidative Stress in the Senescence Pattern of Auditory Cells in Age-Related Hearing Loss

  • Luz del Mar Rivas-Chacón,
  • Sofía Martínez-Rodríguez,
  • Raquel Madrid-García,
  • Joaquín Yanes-Díaz,
  • Juan Ignacio Riestra-Ayora,
  • Ricardo Sanz-Fernández and
  • Carolina Sánchez-Rodríguez

21 September 2021

Age-related hearing loss (ARHL) is an increasing and gradual sensorineural hearing dysfunction. Oxidative stress is an essential factor in developing ARHL; additionally, premature senescence of auditory cells induced by oxidative stress can produce h...

  • Article
  • Open Access
26 Citations
4,996 Views
16 Pages

Sulfane Sulfur Regulates LasR-Mediated Quorum Sensing and Virulence in Pseudomonas aeruginosa PAO1

  • Guanhua Xuan,
  • Chuanjuan Lv,
  • Huangwei Xu,
  • Kai Li,
  • Huaiwei Liu,
  • Yongzhen Xia and
  • Luying Xun

21 September 2021

Sulfane sulfur, such as inorganic and organic polysulfide (HSn− and RSn−, n > 2), is a common cellular component, produced either from hydrogen sulfide oxidation or cysteine metabolism. In Pseudomonas aeruginosa PAO1, LasR is a quorum sensing mast...

  • Review
  • Open Access
2 Citations
3,014 Views
15 Pages

21 September 2021

Marine species deteriorate rapidly post-mortem as a consequence of a variety of biochemical and microbial breakdown mechanisms. Due to the increasing demand for high-quality fresh seafood, different strategies are now available to retard spoilage for...

  • Review
  • Open Access
21 Citations
6,540 Views
13 Pages

21 September 2021

Plants evolved specialized metabolic pathways through gene duplication and functional divergence of enzymes involved in primary metabolism. The results of this process are varied pathways that produce an array of natural products useful to both plant...

  • Article
  • Open Access
7 Citations
5,033 Views
10 Pages

Alpha-Ketoglutarate: A Potential Inner Mitochondrial and Cytosolic Protector against Peroxynitrite and Peroxynitrite-Induced Nitration?

  • Joachim Greilberger,
  • Michaela Greilberger,
  • Reinhold Wintersteiger,
  • Klaus Zangger and
  • Ralf Herwig

21 September 2021

The generation of peroxynitrite (ONOO−) is associated with several diseases, including atherosclerosis, hypertension, neurodegeneration, cancer, inflammation, and sepsis. Alpha-ketoglutarate (αKG) is a known potential highly antioxidative agent for r...

  • Article
  • Open Access
17 Citations
4,121 Views
24 Pages

Peroxisomal PEX7 Receptor Affects Cadmium-Induced ROS and Auxin Homeostasis in Arabidopsis Root System

  • Diego Piacentini,
  • Federica Della Rovere,
  • Ilaria Bertoldi,
  • Lorenzo Massimi,
  • Adriano Sofo,
  • Maria Maddalena Altamura and
  • Giuseppina Falasca

20 September 2021

Peroxisomes are important in plant physiological functions and stress responses. Through the production of reactive oxygen and nitrogen species (ROS and RNS), and antioxidant defense enzymes, peroxisomes control cellular redox homeostasis. Peroxin (P...

  • Article
  • Open Access
11 Citations
3,021 Views
11 Pages

20 September 2021

Inflammation and oxidative stress after hypoxic-ischemic brain injury may be modified by genetic variability in addition to therapeutic hypothermia. The aim of our study was to evaluate the association between the polymorphisms in genes of antioxidan...

  • Review
  • Open Access
5 Citations
7,389 Views
21 Pages

Management of Feline Hyperthyroidism and the Need to Prevent Oxidative Stress: What Can We Learn from Human Research?

  • Alessia Candellone,
  • Vittorio Saettone,
  • Paola Badino,
  • Flavia Girolami,
  • Elisabetta Radice,
  • Domenico Bergero,
  • Rosangela Odore and
  • Giorgia Meineri

20 September 2021

Feline hyperthyroidism is a clinical syndrome related to an excessive production of thyroid hormones, and it is considered as a spontaneous animal model for human thyrotoxicosis. Many shared features between the feline and the human disease have been...

  • Article
  • Open Access
8 Citations
3,657 Views
24 Pages

Transcriptomics Underlying Pulmonary Ozone Pathogenesis Regulated by Inflammatory Mediators in Mice

  • Hye-Youn Cho,
  • Anne E. Jedlicka,
  • Frederick H. Chang,
  • Jacqui Marzec,
  • Alison K. Bauer and
  • Steven R. Kleeberger

18 September 2021

Ozone (O3) is the predominant oxidant air pollutant associated with airway inflammation, lung dysfunction, and the worsening of preexisting respiratory diseases. We previously demonstrated the injurious roles of pulmonary immune receptors, tumor necr...

  • Article
  • Open Access
13 Citations
3,759 Views
18 Pages

H2O2-Mediated Oxidative Stress Enhances Cystathionine γ-Lyase-Derived H2S Synthesis via a Sulfenic Acid Intermediate

  • Jun Wang,
  • Guanya Jia,
  • Heng Li,
  • Shasha Yan,
  • Jing Qian,
  • Xin Guo,
  • Ge Li,
  • Haizhen Qi,
  • Zhilong Zhu and
  • Yanjun Wu
  • + 2 authors

18 September 2021

Hydrogen sulfide (H2S), which is generated mainly by cystathionine γ-lyase (CSE) in the cardiovascular system, plays a pivotal role in a wide range of physiological and pathological processes. However, the regulatory mechanism of the CSE/H2S system i...

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Antioxidants - ISSN 2076-3921Creative Common CC BY license