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Antioxidants, Volume 10, Issue 9

September 2021 - 173 articles

Cover Story: Sepsis, an exaggerated immune response upon infection, annually kills more than 10 million people. The major causative agent is bacterial lipopolysaccharide (LPS), and one of its first targets is the endothelium, the inner lining of all blood vessels, which reacts with activation and apoptosis. We have previously shown that an N-terminal peptide of the apurinic/apyrimidinic endodeoxyribonuclease 1 (APEX1) can inhibit apoptosis of endothelial cells (EC). In the current work, we demonstrate that expression of the endoplasmic reticulum resident selenoprotein T (SELENOT) is upregulated by LPS exclusively in EC expressing the APEX1 peptide. Moreover, SELENOT overexpression protects EC against LPS-induced activation and apoptosis. Thus, the APEX1 peptide or SELENOT could provide new therapeutic approaches in the treatment of sepsis. View this paper.
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Articles (173)

  • Systematic Review
  • Open Access
40 Citations
4,429 Views
14 Pages

Male Disadvantage in Oxidative Stress-Associated Complications of Prematurity: A Systematic Review, Meta-Analysis and Meta-Regression

  • Elke van Westering-Kroon,
  • Maurice J Huizing,
  • Eduardo Villamor-Martínez and
  • Eduardo Villamor

18 September 2021

A widely accepted concept is that boys are more susceptible than girls to oxidative stress-related complications of prematurity, including bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), necrotizing enterocolitis (NEC), intraventr...

  • Article
  • Open Access
22 Citations
4,395 Views
12 Pages

Fisetin Protects HaCaT Human Keratinocytes from Fine Particulate Matter (PM2.5)-Induced Oxidative Stress and Apoptosis by Inhibiting the Endoplasmic Reticulum Stress Response

  • Ilandarage Menu Neelaka Molagoda,
  • Mirissa Hewage Dumindu Kavinda,
  • Yung Hyun Choi,
  • Hyesook Lee,
  • Chang-Hee Kang,
  • Mi-Hwa Lee,
  • Chang-Min Lee and
  • Gi-Young Kim

18 September 2021

Fine particulate matter (PM2.5) originates from the combustion of coal and is found in the exhaust of fumes of diesel vehicles. PM2.5 readily penetrates the skin via the aryl hydrocarbon receptor, causing skin senescence, inflammatory skin diseases,...

  • Article
  • Open Access
57 Citations
5,515 Views
15 Pages

18 September 2021

Deoxynivalenol (DON) is a threatening mycotoxin primarily present in the agricultural environment, especially in food commodities and animal forages, and exerts significant global health hazards. Lycopene (LYC) is a potent antioxidant carotenoid main...

  • Review
  • Open Access
51 Citations
6,815 Views
17 Pages

NRF2 in Viral Infection

  • Angela Herengt,
  • Jacob Thyrsted and
  • Christian K. Holm

18 September 2021

The transcription factor NRF2 is central to redox homeostasis in animal cells and is a well-known driver of chemoresistance in many types of cancer. Recently, new roles have been ascribed to NRF2 which include regulation of antiviral interferon respo...

  • Article
  • Open Access
36 Citations
6,064 Views
18 Pages

Genome-Wide Characterization of Glutathione Peroxidase (GPX) Gene Family in Rapeseed (Brassica napus L.) Revealed Their Role in Multiple Abiotic Stress Response and Hormone Signaling

  • Wei Li,
  • Xuemin Huai,
  • Peitao Li,
  • Ali Raza,
  • Muhammad Salman Mubarik,
  • Madiha Habib,
  • Sajid Fiaz,
  • Binbin Zhang,
  • Jun Pan and
  • Rao Sohail Ahmad Khan

17 September 2021

Plant glutathione peroxidases (GPXs) are the main enzymes in the antioxidant defense system that sustain H2O2 homeostasis and normalize plant reaction to abiotic stress conditions. To understand the major roles of the GPX gene family in rapeseed (Bra...

  • Article
  • Open Access
28 Citations
4,475 Views
14 Pages

Melatonin Enhances the Mitochondrial Functionality of Brown Adipose Tissue in Obese—Diabetic Rats

  • Ahmad Agil,
  • Miguel Navarro-Alarcon,
  • Fatma Abo Zakaib Ali,
  • Ashraf Albrakati,
  • Diego Salagre,
  • Cristina Campoy and
  • Ehab Kotb Elmahallawy

17 September 2021

Developing novel drugs/targets remains a major effort toward controlling obesity-related type 2 diabetes (diabesity). Melatonin controls obesity and improves glucose homeostasis in rodents, mainly via the thermogenic effects of increasing the amount...

  • Article
  • Open Access
10 Citations
4,292 Views
22 Pages

Aryl Hydrocarbon Receptor and Cysteine Redox Dynamics Underlie (Mal)adaptive Mechanisms to Chronic Intermittent Hypoxia in Kidney Cortex

  • Maria João Correia,
  • António B. Pimpão,
  • Filipa Lopes-Coelho,
  • Catarina O. Sequeira,
  • Nuno R. Coelho,
  • Clara Gonçalves-Dias,
  • Robert Barouki,
  • Xavier Coumoul,
  • Jacinta Serpa and
  • Judit Morello
  • + 2 authors

17 September 2021

We hypothesized that an interplay between aryl hydrocarbon receptor (AhR) and cysteine-related thiolome at the kidney cortex underlies the mechanisms of (mal)adaptation to chronic intermittent hypoxia (CIH), promoting arterial hypertension (HTN). Usi...

  • Review
  • Open Access
31 Citations
58,274 Views
79 Pages

17 September 2021

Biomolecular condensates are membraneless organelles (MLOs) that form dynamic, chemically distinct subcellular compartments organizing macromolecules such as proteins, RNA, and DNA in unicellular prokaryotic bacteria and complex eukaryotic cells. Sep...

  • Article
  • Open Access
21 Citations
4,256 Views
19 Pages

Glyoxal-Lysine Dimer, an Advanced Glycation End Product, Induces Oxidative Damage and Inflammatory Response by Interacting with RAGE

  • Hee-Weon Lee,
  • Min Ji Gu,
  • Yoonsook Kim,
  • Jee-Young Lee,
  • Seungju Lee,
  • In-Wook Choi and
  • Sang Keun Ha

17 September 2021

The glyoxal-lysine dimer (GOLD), which is a glyoxal (GO)-derived advanced glycation end product (AGE), is produced by the glycation reaction. In this study, we evaluated the effect of GOLD on the oxidative damage and inflammatory response in SV40 MES...

  • Article
  • Open Access
8 Citations
3,296 Views
17 Pages

An Ascorbate Bluetooth© Analyzer for Quality Control of Fresh-Cut Parsley Supply Chain

  • Ylenia Spissu,
  • Antonio Barberis,
  • Guy D’hallewin,
  • Germano Orrù,
  • Alessandra Scano,
  • Gavina Rita Serra,
  • Milo Pinna,
  • Cristian Pinna,
  • Salvatore Marceddu and
  • Pier Andrea Serra

17 September 2021

This work provides companies in the fresh-cut produce sector with an Ascorbate Bluetooth© Analyzer (ABA), a screen-printed sensor-based device for ascorbic acid (AA) detection, for quality control all along the supply chain. The amperometric detectio...

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Antioxidants - ISSN 2076-3921Creative Common CC BY license