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Antioxidants, Volume 10, Issue 8

August 2021 - 173 articles

Cover Story: Sepsis causes high mortality in the context of septic shock. Here, we investigate the effects of Lira in a polymicrobial sepsis model of cecal ligation and puncture (CLP).
Aortic vascular function (isometric tension recording), protein expression (immunohistochemistry and dot blot), and gene expression (qRT-PCR) were determined. We demonstrate that the GLP-1 analog Lira ameliorates sepsis-induced endothelial dysfunction by the reduction of vascular inflammation and oxidative stress. Accordingly, the findings suggest that the antioxidant and anti-inflammatory effects of GLP-1 analogs may be a valuable tool to protect the cardiovascular system from dysbalanced inflammation in polymicrobial sepsis. View this paper.
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Articles (173)

  • Article
  • Open Access
18 Citations
5,548 Views
15 Pages

Bilberry (Vaccinium myrtillus L.) Powder Has Anticarcinogenic Effects on Oral Carcinoma In Vitro and In Vivo

  • Matti Mauramo,
  • Tuulia Onali,
  • Wafa Wahbi,
  • Jenni Vasara,
  • Anniina Lampinen,
  • Elina Mauramo,
  • Anne Kivimäki,
  • Stefan Martens,
  • Hely Häggman and
  • Meeri Sutinen
  • + 1 author

22 August 2021

Previous studies indicate that bilberry with high amounts of phenolic compounds can inhibit carcinogenic processes of colorectal cancer in vitro and in vivo. However, no studies have focused on the effects of bilberry on oral cancer. In this study, w...

  • Review
  • Open Access
144 Citations
83,039 Views
24 Pages

21 August 2021

Vitamin B3 (nicotinic acid, niacin) deficiency causes the systemic disease pellagra, which leads to dermatitis, diarrhea, dementia, and possibly death depending on its severity and duration. Vitamin B3 is used in the synthesis of the NAD+ family of c...

  • Review
  • Open Access
27 Citations
5,509 Views
18 Pages

21 August 2021

In neuronal precursors and immature neurons, the depolarizing (excitatory) effect of γ-Aminobutyric acid (GABA) signaling is associated with elevated [Cl−]i; as brain cells mature, a developmental switch occurs, leading to the decrease of [Cl−]i and...

  • Article
  • Open Access
39 Citations
5,654 Views
19 Pages

21 August 2021

Using ultrasound (US) in proanthocyanidin (PA) extraction has become one of the important emerging technologies. It could be the next generation for studying the US mechnophore impact on the bioactive compound’s functionality. The objective of this s...

  • Review
  • Open Access
6 Citations
2,839 Views
11 Pages

Involvement of microRNAs as a Response to Phototherapy and Photodynamic Therapy: A Literature Review

  • Francesco Borgia,
  • Paolo Custurone,
  • Lucia Peterle,
  • Giovanni Pioggia,
  • Fabrizio Guarneri and
  • Sebastiano Gangemi

20 August 2021

The current knowledge about the mechanisms of action of light-based treatments (chiefly photodynamic therapy and phototherapy) in skin diseases leans to the possible involvement of epigenetic and oxidative stress mechanisms. To better understand and...

  • Article
  • Open Access
23 Citations
3,820 Views
17 Pages

Expression of Endothelial NOX5 Alters the Integrity of the Blood-Brain Barrier and Causes Loss of Memory in Aging Mice

  • Adriana Cortés,
  • Maite Solas,
  • Álvaro Pejenaute,
  • Miguel A. Abellanas,
  • Marcos Garcia-Lacarte,
  • Maria S. Aymerich,
  • Javier Marqués,
  • María J. Ramírez and
  • Guillermo Zalba

20 August 2021

Blood-Brain barrier (BBB) disruption is a hallmark of central nervous system (CNS) dysfunction, and oxidative stress is one of the molecular mechanisms that may underlie this process. NADPH oxidases (NOX) are involved in oxidative stress-mediated vas...

  • Article
  • Open Access
80 Citations
6,306 Views
13 Pages

20 August 2021

This study aimed to investigate the key constituents and preliminary mechanism for the hypolipidemic activity of chrysanthemum flavonoids. Hyperlipidemia (HPL) rats were divided into five groups: the model control group (MC); Chrysanthemum flavone in...

  • Article
  • Open Access
48 Citations
7,457 Views
37 Pages

Impact of Drying Processes on the Nutritional Composition, Volatile Profile, Phytochemical Content and Bioactivity of Salicornia ramosissima J. Woods

  • Sheila C. Oliveira-Alves,
  • Fábio Andrade,
  • Inês Prazeres,
  • Andreia B. Silva,
  • Jorge Capelo,
  • Bernardo Duarte,
  • Isabel Caçador,
  • Júlio Coelho,
  • Ana Teresa Serra and
  • Maria R. Bronze

20 August 2021

Salicornia ramosissima J. Woods is a halophyte plant recognized as a promising natural ingredient and will eventually be recognized a salt substitute (NaCl). However, its shelf-life and applicability in several food matrices requires the use of dryin...

  • Article
  • Open Access
19 Citations
3,403 Views
10 Pages

Effects of Fusarium Mycotoxin Exposure on Lipid Peroxidation and Glutathione Redox System in the Liver of Laying Hens

  • Szabina Kulcsár,
  • Benjámin Kövesi,
  • Krisztián Balogh,
  • Erika Zándoki,
  • Zsolt Ancsin,
  • Balláné Erdélyi Márta and
  • Miklós Mézes

20 August 2021

It has been proven by several studies that Fusarium mycotoxins induce oxidative stress in animals, consequently inducing lipid peroxidation, which the glutathione system can neutralize. A short-term (3-day) in vivo feeding trial was performed with la...

  • Article
  • Open Access
24 Citations
6,027 Views
16 Pages

Curcumin Suppresses the Lipid Accumulation and Oxidative Stress Induced by Benzo[a]pyrene Toxicity in HepG2 Cells

  • Seung-Cheol Lee,
  • Seung-Cheol Jee,
  • Min Kim,
  • Soee Kim,
  • Min Kyoung Shin,
  • Yunkyung Kim and
  • Jung-Suk Sung

20 August 2021

Benzo[a]pyrene (B[a]P) is a potentially hepatotoxic group-1 carcinogen taken up by the body through ingestion of daily foods. B[a]P is widely known to cause DNA and protein damages, which are closely related to cell transformation. Accordingly, studi...

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Antioxidants - ISSN 2076-3921