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Review

Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits

1
Ardelyx Inc., Fremont, CA 94555, USA
2
College for Health, Community and Policy, University of Texas, San Antonio, TX 78207, USA
3
Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA
4
Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Silvia M. Arribas
Antioxidants 2021, 10(8), 1161; https://doi.org/10.3390/antiox10081161
Received: 3 May 2021 / Revised: 4 June 2021 / Accepted: 22 June 2021 / Published: 21 July 2021
Ursolic acid (UA) is a well-studied natural pentacyclic triterpenoid found in herbs, fruit and a number of traditional Chinese medicinal plants. UA has a broad range of biological activities and numerous potential health benefits. In this review, we summarize the current data on the bioavailability and pharmacokinetics of UA and review the literature on the biological activities of UA and its closest analogues in the context of inflammation, metabolic diseases, including liver and kidney diseases, obesity and diabetes, cardiovascular diseases, cancer, and neurological disorders. We end with a brief overview of UA’s main analogues with a special focus on a newly discovered naturally occurring analogue with intriguing biological properties and potential health benefits, 23-hydroxy ursolic acid. View Full-Text
Keywords: botanicals; nutraceutical; antioxidants; inflammation; metabolic diseases; atherosclerosis; cancer botanicals; nutraceutical; antioxidants; inflammation; metabolic diseases; atherosclerosis; cancer
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MDPI and ACS Style

Nguyen, H.N.; Ullevig, S.L.; Short, J.D.; Wang, L.; Ahn, Y.J.; Asmis, R. Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits. Antioxidants 2021, 10, 1161. https://doi.org/10.3390/antiox10081161

AMA Style

Nguyen HN, Ullevig SL, Short JD, Wang L, Ahn YJ, Asmis R. Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits. Antioxidants. 2021; 10(8):1161. https://doi.org/10.3390/antiox10081161

Chicago/Turabian Style

Nguyen, Huynh N., Sarah L. Ullevig, John D. Short, Luxi Wang, Yong J. Ahn, and Reto Asmis. 2021. "Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits" Antioxidants 10, no. 8: 1161. https://doi.org/10.3390/antiox10081161

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