Next Article in Journal
Immunohistochemical Analysis of 4-HNE, NGAL, and HO-1 Tissue Expression after Apocynin Treatment and HBO Preconditioning in Postischemic Acute Kidney Injury Induced in Spontaneously Hypertensive Rats
Next Article in Special Issue
Antioxidant Effect of Lonicera caerulea L. in the Cardiovascular System of Obese Zucker Rats
Previous Article in Journal
Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits
Previous Article in Special Issue
Addition of Olive Leaf Extract to a Mixture of Algae and Extra Virgin Olive Oils Decreases Fatty Acid Oxidation and Synergically Attenuates Age-Induced Hypertension, Sarcopenia and Insulin Resistance in Rats
Review

Blueberry as An Attractive Functional Fruit to Prevent (Pre)Diabetes Progression

by 1,2,3, 1,2,3, 1,2,3,4,5, 1,2,3,6,* and 1,2,3,*
1
Institute of Pharmacology & Experimental Therapeutics & Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal
2
Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3004-504 Coimbra, Portugal
3
Clinical Academic Center of Coimbra (CACC), 3004-504 Coimbra, Portugal
4
Department of Biomedicine, Faculty of Medicine, University of Porto, 4200-450 Porto, Portugal
5
CINTESIS—Center for Health Technology and Services Research, University of Porto, 4200-450 Porto, Portugal
6
Pharmacy/Biomedical Laboratory Sciences, Polytechnic Institute of Coimbra, ESTESC-Coimbra Health School, 3046-854 Coimbra, Portugal
*
Authors to whom correspondence should be addressed.
Academic Editors: Silvia M. Arribas and Maria Angeles Martín-Cabrejas
Antioxidants 2021, 10(8), 1162; https://doi.org/10.3390/antiox10081162
Received: 16 June 2021 / Revised: 16 July 2021 / Accepted: 19 July 2021 / Published: 22 July 2021
(This article belongs to the Special Issue Antioxidant Foods and Cardiometabolic Health)
Prediabetes, a subclinical impairment between euglycemia and hyperglycemia, is a risk factor for the development of type 2 diabetes mellitus (T2DM) and associated micro- and macrovascular complications. Lifestyle therapy, the first-line treatment of prediabetes, includes physical exercise and dietary regimens enriched in phytochemicals with health-related properties. Blueberries (Vaccinium spp.), given their pleasant taste and great abundance in beneficial phytochemicals, have gained public interest all over the world. Along with a high antioxidant activity, this functional fruit is also well-recognized due to its hypoglycemic and insulin-sensitizing effects and has been recommended for overt T2DM management. Yet blueberries target several other pathophysiological traits, namely gut microbiota dysbiosis and hepatic dysmetabolism, that ensue when prediabetes begins and for which pharmacological interventions tend to be delayed. In this work, we revisited preclinical data from in vitro assays, animal models and human studies, aiming to disclose the potential mechanisms by which blueberries may be a fruitful source of phytochemicals able to prevent (pre)diabetes progression. Collectively, future efforts should focus on longer-term studies with standardized interventions and readouts, particularly in humans, that will hopefully bring more robust evidence and concrete guidance for blueberries’ effective use in prediabetes. View Full-Text
Keywords: blueberries; antioxidants; prediabetes; hepatic dysmetabolism; gut microbiota dysbiosis blueberries; antioxidants; prediabetes; hepatic dysmetabolism; gut microbiota dysbiosis
Show Figures

Figure 1

MDPI and ACS Style

Nunes, S.; Vieira, P.; Gomes, P.; Viana, S.D.; Reis, F. Blueberry as An Attractive Functional Fruit to Prevent (Pre)Diabetes Progression. Antioxidants 2021, 10, 1162. https://doi.org/10.3390/antiox10081162

AMA Style

Nunes S, Vieira P, Gomes P, Viana SD, Reis F. Blueberry as An Attractive Functional Fruit to Prevent (Pre)Diabetes Progression. Antioxidants. 2021; 10(8):1162. https://doi.org/10.3390/antiox10081162

Chicago/Turabian Style

Nunes, Sara, Pedro Vieira, Pedro Gomes, Sofia D. Viana, and Flávio Reis. 2021. "Blueberry as An Attractive Functional Fruit to Prevent (Pre)Diabetes Progression" Antioxidants 10, no. 8: 1162. https://doi.org/10.3390/antiox10081162

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop