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Blueberry as an Attractive Functional Fruit to Prevent (Pre)Diabetes Progression

by 1,2,3, 1,2,3, 1,2,3,4,5, 1,2,3,6,* and 1,2,3,*
Institute of Pharmacology & Experimental Therapeutics & Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal
Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3004-504 Coimbra, Portugal
Clinical Academic Center of Coimbra (CACC), 3004-504 Coimbra, Portugal
Department of Biomedicine, Faculty of Medicine, University of Porto, 4200-450 Porto, Portugal
CINTESIS—Center for Health Technology and Services Research, University of Porto, 4200-450 Porto, Portugal
Pharmacy/Biomedical Laboratory Sciences, Polytechnic Institute of Coimbra, ESTESC-Coimbra Health School, 3046-854 Coimbra, Portugal
Authors to whom correspondence should be addressed.
Academic Editors: Silvia M. Arribas and Maria Angeles Martín-Cabrejas
Antioxidants 2021, 10(8), 1162;
Received: 16 June 2021 / Revised: 16 July 2021 / Accepted: 19 July 2021 / Published: 22 July 2021
(This article belongs to the Special Issue Antioxidant Foods and Cardiometabolic Health)
Prediabetes, a subclinical impairment between euglycemia and hyperglycemia, is a risk factor for the development of type 2 diabetes mellitus (T2DM) and associated micro- and macrovascular complications. Lifestyle therapy, the first-line treatment of prediabetes, includes physical exercise and dietary regimens enriched in phytochemicals with health-related properties. Blueberries (Vaccinium spp.), given their pleasant taste and great abundance in beneficial phytochemicals, have gained public interest all over the world. Along with a high antioxidant activity, this functional fruit is also well-recognized due to its hypoglycemic and insulin-sensitizing effects and has been recommended for overt T2DM management. Yet blueberries target several other pathophysiological traits, namely gut microbiota dysbiosis and hepatic dysmetabolism, that ensue when prediabetes begins and for which pharmacological interventions tend to be delayed. In this work, we revisited preclinical data from in vitro assays, animal models and human studies, aiming to disclose the potential mechanisms by which blueberries may be a fruitful source of phytochemicals able to prevent (pre)diabetes progression. Collectively, future efforts should focus on longer-term studies with standardized interventions and readouts, particularly in humans, that will hopefully bring more robust evidence and concrete guidance for blueberries’ effective use in prediabetes. View Full-Text
Keywords: blueberries; antioxidants; prediabetes; hepatic dysmetabolism; gut microbiota dysbiosis blueberries; antioxidants; prediabetes; hepatic dysmetabolism; gut microbiota dysbiosis
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MDPI and ACS Style

Nunes, S.; Vieira, P.; Gomes, P.; Viana, S.D.; Reis, F. Blueberry as an Attractive Functional Fruit to Prevent (Pre)Diabetes Progression. Antioxidants 2021, 10, 1162.

AMA Style

Nunes S, Vieira P, Gomes P, Viana SD, Reis F. Blueberry as an Attractive Functional Fruit to Prevent (Pre)Diabetes Progression. Antioxidants. 2021; 10(8):1162.

Chicago/Turabian Style

Nunes, Sara, Pedro Vieira, Pedro Gomes, Sofia Domingues Viana, and Flávio Reis. 2021. "Blueberry as an Attractive Functional Fruit to Prevent (Pre)Diabetes Progression" Antioxidants 10, no. 8: 1162.

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