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Antioxidants, Volume 10, Issue 1

January 2021 - 138 articles

Cover Story: The enzyme CYP1A2 is responsible for the metabolism of caffeine into paraxanthine. Both molecules are known for their antioxidant and pro-oxidant characteristics, and the paraxanthine-to-caffeine molar ratio is a widely accepted metric for CYP1A2 phenotyping for optimizing dose–response effects in individual patients. This work presents the simultaneous quantification of caffeine and paraxanthine in spiked human saliva samples by differential pulse voltammetry using an anodically pretreated glassy carbon electrode. Potential applicability of the sensing platform was demonstrated by running a small-scale trial on five healthy volunteers. The results were validated by ultra-high-pressure liquid chromatography and shown to have a high correlation factor (r = 0.994). View this paper
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Articles (138)

  • Article
  • Open Access
21 Citations
5,464 Views
19 Pages

Extra Virgin Olive Oil Phenolic Extract on Human Hepatic HepG2 and Intestinal Caco-2 Cells: Assessment of the Antioxidant Activity and Intestinal Trans-Epithelial Transport

  • Martina Bartolomei,
  • Carlotta Bollati,
  • Maria Bellumori,
  • Lorenzo Cecchi,
  • Ivan Cruz-Chamorro,
  • Guillermo Santos-Sánchez,
  • Giulia Ranaldi,
  • Simonetta Ferruzza,
  • Yula Sambuy and
  • Anna Arnoldi
  • + 2 authors

15 January 2021

In the framework of research aimed at promoting the nutraceutical properties of the phenolic extract (BUO) obtained from an extra virgin olive oil of the Frantoio cultivar cultivated in Tuscany (Italy), with a high total phenols content, this study p...

  • Article
  • Open Access
12 Citations
5,450 Views
17 Pages

Propagation of Mitochondria-Derived Reactive Oxygen Species within the Dipodascus magnusii Cells

  • Anton G. Rogov,
  • Tatiana N. Goleva,
  • Khoren K. Epremyan,
  • Igor I. Kireev and
  • Renata A. Zvyagilskaya

15 January 2021

Mitochondria are considered to be the main source of reactive oxygen species (ROS) in the cell. It was shown that in cardiac myocytes exposed to excessive oxidative stress, ROS-induced ROS release is triggered. However, cardiac myocytes have a networ...

  • Article
  • Open Access
35 Citations
5,748 Views
21 Pages

Mitochondrial Metabolism as Target of the Neuroprotective Role of Erythropoietin in Parkinson’s Disease

  • Federica Rey,
  • Sara Ottolenghi,
  • Toniella Giallongo,
  • Alice Balsari,
  • Carla Martinelli,
  • Robert Rey,
  • Raffaele Allevi,
  • Anna Maria Di Giulio,
  • Gian Vincenzo Zuccotti and
  • Serena Mazzucchelli
  • + 3 authors

15 January 2021

Existing therapies for Parkinson’s disease (PD) are only symptomatic. As erythropoietin (EPO) is emerging for its benefits in neurodegenerative diseases, here, we test the protective effect driven by EPO in in vitro (SH-SY5Y cells challenged by...

  • Article
  • Open Access
17 Citations
4,823 Views
19 Pages

Novel Antioxidant, Deethylated Ethoxyquin, Protects against Carbon Tetrachloride Induced Hepatotoxicity in Rats by Inhibiting NLRP3 Inflammasome Activation and Apoptosis

  • Igor Y. Iskusnykh,
  • Evgenii D. Kryl’skii,
  • Darya A. Brazhnikova,
  • Tatyana N. Popova,
  • Khidmet S. Shikhaliev,
  • Konstantin K. Shulgin,
  • Larisa V. Matasova,
  • Sergey S. Popov,
  • Dmitry A. Zhaglin and
  • Anastasia A. Zakharova
  • + 2 authors

15 January 2021

Inflammation and an increase in antioxidant responses mediated by oxidative stress play an important role in the pathogenesis of acute liver injury (ALI). We utilized in silico prediction of biological activity spectra for substances (PASS) analysis...

  • Article
  • Open Access
50 Citations
5,548 Views
15 Pages

Phenolic Profiles, Antioxidant Activity and Phenotypic Characterization of Lonicera caerulea L. Berries, Cultivated in Lithuania

  • Lina Raudonė,
  • Mindaugas Liaudanskas,
  • Gabrielė Vilkickytė,
  • Darius Kviklys,
  • Vaidotas Žvikas,
  • Jonas Viškelis and
  • Pranas Viškelis

15 January 2021

Lonicera caerulea L. is an early fruit-bearing plant that originates from harsh environments. Raw materials contain a body of different phenolic origin compounds that determine the multidirectional antioxidant and pharmacological activities. The aim...

  • Article
  • Open Access
7 Citations
4,705 Views
13 Pages

14 January 2021

Although the hallmarks of Alzheimer’s disease (AD) are amyloid beta plaques and neurofibrillary tangles, there is growing evidence that neuroinflammation, mitochondrial dysfunction and oxidative stress play important roles in disease developmen...

  • Article
  • Open Access
32 Citations
4,332 Views
15 Pages

Potential Antioxidant Properties of Enzymatic Hydrolysates from Stichopus japonicus against Hydrogen Peroxide-Induced Oxidative Stress

  • Hyo-Geun Lee,
  • Hyun-Soo Kim,
  • Jae-Young Oh,
  • Dae-Sung Lee,
  • Hye-Won Yang,
  • Min-Cheol Kang,
  • Eun-A Kim,
  • Nalae Kang,
  • Junseong Kim and
  • Soo-Jin Heo
  • + 1 author

14 January 2021

A comprehensive antioxidant evaluation was performed on enzymatic hydrolysates of Stichopusjaponicus (S. japonicus) using Vero cells and zebrafish models for in vitro and in vivo studies, respectively. S. japonicus was hydrolyzed with food-grade enzy...

  • Article
  • Open Access
10 Citations
3,169 Views
12 Pages

14 January 2021

Protein tyrosine phosphatases (PTPs) can be regulated by several redox-dependent mechanisms and control growth factor-activated receptor tyrosine kinase phosphorylation cascades. Reversible oxidation of PTPs is counteracted by reductive enzymes, incl...

  • Article
  • Open Access
60 Citations
9,665 Views
14 Pages

Antioxidant Effects of Turmeric Leaf Extract against Hydrogen Peroxide-Induced Oxidative Stress In Vitro in Vero Cells and In Vivo in Zebrafish

  • Sera Kim,
  • Mingyeong Kim,
  • Min-Cheol Kang,
  • Hyun Hee L. Lee,
  • Chi Heung Cho,
  • Inwook Choi,
  • Yongkon Park and
  • Sang-Hoon Lee

14 January 2021

Oxidative stress, caused by the excessive production of reactive oxygen species (ROS), results in cellular damage. Therefore, functional materials with antioxidant properties are necessary to maintain redox balance. Turmeric leaves (Curcuma longa L....

  • Article
  • Open Access
14 Citations
9,694 Views
11 Pages

Astaxanthin-, β-Carotene-, and Resveratrol-Rich Foods Support Resistance Training-Induced Adaptation

  • Aki Kawamura,
  • Wataru Aoi,
  • Ryo Abe,
  • Yukiko Kobayashi,
  • Masashi Kuwahata and
  • Akane Higashi

14 January 2021

Resistance training adaptively increases the muscle strength associated with protein anabolism. Previously, we showed that the combined intake of astaxanthin, β-carotene, and resveratrol can accelerate protein anabolism in the skeletal muscle of...

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Antioxidants - ISSN 2076-3921