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Antioxidants, Volume 10, Issue 12

December 2021 - 175 articles

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Cover Story: Glutathione plays a key role in maintaining a physiological balance between prooxidants and antioxidants in the human body. This work presents the influence of maternal smoking as a source of oxidative stress measured by total oxidant capacity (TOC) on reduced glutathione (GSH), oxidized glutathione (GSSG), glutathione peroxidase (GPx-3), and reductase (GR) amount in maternal and umbilical cord blood. We found that oxidative stress generated by the toxic compounds in cigarette smoke impairs the homeostasis of glutathione in both mother and newborn. A twice lower value of the cell’s redox status index expressed by the GSH/GSSG ratio in neonates of smoking mothers compared to the non-smoking group may confirm the negative influence of maternal smoking on the oxidative–antioxidant balance in newborns. View this paper

Articles (175)

  • Article
  • Open Access
24 Citations
4,464 Views
16 Pages

CCN2 Aggravates the Immediate Oxidative Stress–DNA Damage Response following Renal Ischemia–Reperfusion Injury

  • Floris A. Valentijn,
  • Sebastiaan N. Knoppert,
  • Georgios Pissas,
  • Raúl R. Rodrigues-Diez,
  • Laura Marquez-Exposito,
  • Roel Broekhuizen,
  • Michal Mokry,
  • Lennart A. Kester,
  • Lucas L. Falke and
  • Roel Goldschmeding
  • + 3 authors

20 December 2021

AKI, due to the fact of altered oxygen supply after kidney transplantation, is characterized by renal ischemia–reperfusion injury (IRI). Recent data suggest that AKI to CKD progression may be driven by cellular senescence evolving from prolonge...

  • Article
  • Open Access
5 Citations
3,904 Views
18 Pages

20 December 2021

European beech is an important component of European lowland forests in terms of ecology, and produces irregular seeds categorized as intermediate due to their limited longevity. Removal of the excess of reactive oxygen species is crucial for redox h...

  • Article
  • Open Access
19 Citations
6,264 Views
13 Pages

Mild Coronavirus Disease 2019 (COVID-19) Is Marked by Systemic Oxidative Stress: A Pilot Study

  • Larissa E. van Eijk,
  • Adriana Tami,
  • Jan-Luuk Hillebrands,
  • Wilfred F. A. den Dunnen,
  • Martin H. de Borst,
  • Peter H. J. van der Voort,
  • Marian L. C. Bulthuis,
  • Alida C. M. Veloo,
  • Karin I. Wold and
  • María F. Vincenti González
  • + 3 authors

20 December 2021

Oxidative stress has been implicated to play a critical role in the pathophysiology of coronavirus disease 2019 (COVID-19) and may therefore be considered as a relevant therapeutic target. Serum free thiols (R-SH, sulfhydryl groups) comprise a robust...

  • Article
  • Open Access
8 Citations
3,563 Views
17 Pages

20 December 2021

Grafting with pumpkin rootstock could improve chilling tolerance in watermelon, and salicylic acid (SA) as a signal molecule is involved in regulating plant tolerance to chilling and other abiotic stresses. To clarify the mechanism in pumpkin rootsto...

  • Article
  • Open Access
27 Citations
6,942 Views
16 Pages

20 December 2021

Skin ageing is influenced by several factors including environmental exposure and hormonal changes. Reactive oxygen species (ROS), which mediate many of the effects of these factors, induce inflammatory processes in the skin and increase the producti...

  • Article
  • Open Access
8 Citations
3,532 Views
14 Pages

20 December 2021

Recent studies have highlighted the potential of utilizing carob kibbles as a bioactive-rich food ingredient associated with substantial health benefits. Roasting is a key process in enhancing the sensory characteristics of carob kibbles, also affect...

  • Article
  • Open Access
6 Citations
3,619 Views
11 Pages

Dried Blood Spot Biomarkers of Oxidative Stress and Inflammation Associated with Blood Pressure in Rural Senegalese Women with Incident Hypertension

  • Yan Lin,
  • Xiangtian Wang,
  • Luciane Lenz,
  • Ousmane Ndiaye,
  • Jian Qin,
  • Xiaoli Wang,
  • Hui Huang,
  • Marc A. Jeuland and
  • Junfeng Zhang

20 December 2021

Blood biomarkers of oxidative stress and inflammation have been associated with increased risk of hypertension development; yet their application in sub-Saharan Africa has been limited due to the lack of blood collection facilities. In this study, we...

  • Article
  • Open Access
10 Citations
3,113 Views
20 Pages

A Correlation Study on In Vitro Physiological Activities of Soybean Cultivars, 19 Individual Isoflavone Derivatives, and Genetic Characteristics

  • Han-Na Chu,
  • Su-Ji Lee,
  • Xiaohan Wang,
  • Sang-Hoon Lee,
  • Hye-Myeong Yoon,
  • Yu-Jin Hwang,
  • Eun-Suk Jung,
  • Yongseok Kwon,
  • Chi-Do Wee and
  • Kyeong-A Jang
  • + 1 author

20 December 2021

The functionality of soybeans is an important factor in the selection and utilization of excellent soybean cultivars, and isoflavones are representative functional substances in soybeans, which exhibit effects on antioxidants, estrogen activity, and...

  • Article
  • Open Access
11 Citations
4,098 Views
20 Pages

Long-Term Effects of Biliverdin Reductase a Deficiency in Ugt1−/− Mice: Impact on Redox Status and Metabolism

  • Giulia Bortolussi,
  • Xiaoxia Shi,
  • Lysbeth ten Bloemendaal,
  • Bhaswati Banerjee,
  • Dirk R. De Waart,
  • Gabriele Baj,
  • Weiyu Chen,
  • Ronald P. Oude Elferink,
  • Ulrich Beuers and
  • Coen C. Paulusma
  • + 3 authors

20 December 2021

Accumulation of neurotoxic bilirubin due to a transient neonatal or persistent inherited deficiency of bilirubin glucuronidation activity can cause irreversible brain damage and death. Strategies to inhibit bilirubin production and prevent neurotoxic...

  • Review
  • Open Access
14 Citations
6,143 Views
14 Pages

Preventing Oxidative Stress in the Liver: An Opportunity for GLP-1 and/or PASK

  • Verónica Hurtado-Carneiro,
  • Pilar Dongil,
  • Ana Pérez-García,
  • Elvira Álvarez and
  • Carmen Sanz

20 December 2021

The liver’s high metabolic activity and detoxification functions generate reactive oxygen species, mainly through oxidative phosphorylation in the mitochondria of hepatocytes. In contrast, it also has a potent antioxidant mechanism for counterb...

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