Antioxidant Agents for the Prevention and Therapy of Oxidative Stress in Hepatic Diseases

Dear Colleagues,

Oxidative stress has been implicated in diverse pathological mechanisms, and may contribute to the initiation and progression of liver injury. Risk factors including drugs and alcohol, environmental pollutants and irradiation, and exposure to viruses and bacteria may generate reactive oxygen species (ROS). This results in severe hepatic diseases, such as alcoholic liver disease and non-alcoholic fatty liver disease (NAFLD). Increased ROS production is also involved in ischemia–reperfusion injury (IRI) pathology. IRI is an inherent syndrome associated with liver surgery and organ transplantation where deleterious injury is due to ischemia (oxygen deprivation) and reperfusion (blood and oxygen restoration).

Antioxidant therapy would mean a rational healing strategy in the treatment of liver diseases that involve ROS production. There is a growing interest in the application of natural antioxidants and in the use of antioxidant chemicals to improve or prevent liver disease. For potential new therapeutic targets, more emphasis should be placed on deeper mechanistic investigations of hepatic ischemia–reperfusion injury and on translational research to refine current strategies in the use of antioxidants.

This Special Issue calls for original research and full reviews that address the progress and current knowledge on the mechanism of ROS-mediated liver injury, therapeutic strategies, and the protective role of antioxidants.

Detailed investigations on the mechanism of ROS-mediated liver disease could open new insights for the development of biomarkers and therapeutic approaches.

Contributions need not be limited to the fields mentioned in the keywords.

Dr. Teresa Carbonell Camós
Prof. Dr. Joan Roselló-Catafau
Guest Editors

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