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Volume 10
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10.3390/brainsci10080548
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Article

Effect of Cladribine on Neuronal Apoptosis: New Insight of In Vitro Study in Multiple Sclerosis Therapy

by
Maddalena Ruggieri
1,
Concetta Domenica Gargano
1,
Anna Ferretta
1,
Alessia Manni
1,
Antonio Capacchione
2,
Antonio Frigeri
1,
Pietro Iaffaldano
1,
Maria Trojano
1 and
Damiano Paolicelli
1,*
1
Department of Basic Medical Science, Neuroscience and Sense Organs, School of Medicine, University of Bari Aldo Moro, 70124 Bari, Italy
2
Medical Affairs Department, Merck Serono S.p.A., 00176 Rome, Italy
*
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(8), 548; https://doi.org/10.3390/brainsci10080548
Submission received: 8 July 2020 / Revised: 11 August 2020 / Accepted: 11 August 2020 / Published: 13 August 2020
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Abstract

Background: Cladribine (2-CdA) can cross the blood–brain barrier, resulting in inhibition of DNA synthesis and repair and disruption of cellular proliferation in actively dividing lymphocytes. No data on effect on neurons are available. Aim: To study “in vitro” 2-CdA apoptotic effects on neurons in healthy donor and multiple sclerosis patient lymphocytes. Methods: Neuroblastoma cells were co-cultured with lymphocytes, with and without 2-CdA. Results: Apoptosis increased in lymphocytes with 2-CdA; increase was also observed when lymphocytes were cultured with neuronal cells. However, neurons were not affected by 2-CdA for apoptosis. Conclusions: 2-CdA causes peripheral and central lymphocyte death preserving neurons, with a reasonable impact on inflammation and neuroprotection.
Keywords: multiple sclerosis; cladribine; apoptosis; neurons multiple sclerosis; cladribine; apoptosis; neurons

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MDPI and ACS Style

Ruggieri, M.; Gargano, C.D.; Ferretta, A.; Manni, A.; Capacchione, A.; Frigeri, A.; Iaffaldano, P.; Trojano, M.; Paolicelli, D. Effect of Cladribine on Neuronal Apoptosis: New Insight of In Vitro Study in Multiple Sclerosis Therapy. Brain Sci. 2020, 10, 548. https://doi.org/10.3390/brainsci10080548

AMA Style

Ruggieri M, Gargano CD, Ferretta A, Manni A, Capacchione A, Frigeri A, Iaffaldano P, Trojano M, Paolicelli D. Effect of Cladribine on Neuronal Apoptosis: New Insight of In Vitro Study in Multiple Sclerosis Therapy. Brain Sciences. 2020; 10(8):548. https://doi.org/10.3390/brainsci10080548

Chicago/Turabian Style

Ruggieri, Maddalena, Concetta Domenica Gargano, Anna Ferretta, Alessia Manni, Antonio Capacchione, Antonio Frigeri, Pietro Iaffaldano, Maria Trojano, and Damiano Paolicelli. 2020. "Effect of Cladribine on Neuronal Apoptosis: New Insight of In Vitro Study in Multiple Sclerosis Therapy" Brain Sciences 10, no. 8: 548. https://doi.org/10.3390/brainsci10080548

APA Style

Ruggieri, M., Gargano, C. D., Ferretta, A., Manni, A., Capacchione, A., Frigeri, A., Iaffaldano, P., Trojano, M., & Paolicelli, D. (2020). Effect of Cladribine on Neuronal Apoptosis: New Insight of In Vitro Study in Multiple Sclerosis Therapy. Brain Sciences, 10(8), 548. https://doi.org/10.3390/brainsci10080548

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