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Appl. Sci. 2016, 6(3), 72;

Monitoring Theophylline Concentrations in Saline Using Terahertz ATR Spectroscopy

Department of Electrical and Electronic Engineering Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8603, Japan
Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan
Author to whom correspondence should be addressed.
Academic Editor: Christoph Peter Hauri
Received: 21 November 2015 / Revised: 3 February 2016 / Accepted: 24 February 2016 / Published: 3 March 2016
(This article belongs to the Special Issue Frontiers in Terahertz Science and Technology)
PDF [1182 KB, uploaded 3 March 2016]


To assess the possibility of terahertz technology for the determination of drug concentration in blood, we endeavored to apply a terahertz (THz) attenuated total reflection (ATR) method to measure the levels of theophylline in saline. A change in reflected THz wave amplitude was observed in a theophylline concentration-dependent manner. This result was obtained with simple measurements of comparisons of the amplitude of the reflected wave, and suggests that it is possible to monitor concentration changes of drugs in liquid material using THz ATR measurements. View Full-Text
Keywords: terahertz; attenuated total reflection; therapeutic drug monitoring terahertz; attenuated total reflection; therapeutic drug monitoring

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Takeya, K.; Muto, K.; Ishihara, Y.; Kawase, K. Monitoring Theophylline Concentrations in Saline Using Terahertz ATR Spectroscopy. Appl. Sci. 2016, 6, 72.

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