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Open AccessArticle

Antioxidant, Antimicrobial, Antidiabetic and Cytotoxic Activity of Crocus sativus L. Petals

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Department of Pharmaceutical Chemistry, RAKCOPS, RAK Medical and Health Sciences University, 11172 Ras Al Khaimah, UAE
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Department of Microbiology, RAKCOM, RAK Medical and Health Sciences University, 11172 Ras Al Khaimah, UAE
3
Invasion Biology, Department of Botany, School of Biological Sciences, University of Kashmir, Srinagar, J&K 190006, India
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Department of Clinical Pharmacy, College of Pharmacy, King Saud University, 11451 Riyadh, Saudi Arabia
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Department of Botany and Microbiology, College of Science, King Saud University, 11451 Riyadh, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Appl. Sci. 2020, 10(4), 1519; https://doi.org/10.3390/app10041519
Received: 16 January 2020 / Revised: 11 February 2020 / Accepted: 13 February 2020 / Published: 23 February 2020
(This article belongs to the Special Issue Biomedical Application of Plant Extracts)
The purpose of this research is to examine in vitro antioxidant, antimicrobial, antidiabetic and cytotoxic efficacy of different extracts of Crocus sativus L. petals. Antioxidant activity of extracts was assessed by DPPH and ABTS (2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) assay. Among all extracts, ethanol (SPE) had the maximum radical scavenging activity with IC50 values 86.63 ± 7.53 μg/mL. The antimicrobial activity was determined by the evaluation of the minimum inhibitory concentration using the agar well plate procedure. The most effective extract was SPE with a minimum inhibitory concentration varying between 500 µg/mL, 250 µg/mL, 125 µg/mL, 62.5 µg/mL, 31.25 µg/mL, 15.63 µg/mL. Cytotoxic activity was tested against MDA-MB-231 cell lines using the MTT method whereas, antidiabetic activity was evaluated using an alpha-glucosidase inhibition assay. All extracts were found to have significant antidiabetic activity. View Full-Text
Keywords: anti-diabetic; Crocus sativus L. petals; ABTS assay; cytotoxic; polyphenols; FTIR anti-diabetic; Crocus sativus L. petals; ABTS assay; cytotoxic; polyphenols; FTIR
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Wali, A.F.; Alchamat, H.A.A.; Hariri, H.K.; Hariri, B.K.; Menezes, G.A.; Zehra, U.; Rehman, M.U.; Ahmad, P. Antioxidant, Antimicrobial, Antidiabetic and Cytotoxic Activity of Crocus sativus L. Petals. Appl. Sci. 2020, 10, 1519.

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