Special Issue "Biomedical Application of Plant Extracts"

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemistry".

Deadline for manuscript submissions: closed (31 July 2020).

Special Issue Editors

Dr. Katarzyna Sykłowska-Baranek

Guest Editor
Department of Pharmaceutical Biology and Medicinal Plant Biotechnology, Faculty of Pharmacy with Division of Laboratory Medicine, Medicinal University of Warsaw, Banacha 1 str., 02-097 Warsaw, Poland
Interests: cytotoxic activity; plant extracts; plant biotechnology
Dr. Łukasz Kuźma

Guest Editor
Department of Biology and Pharmaceutical Botany, Medical University of Łodz, Łodz, Poland
Interests: Essential Oils; Agrobacterium; Biotechnology

Special Issue Information

Dear Colleagues,

The Plant Kingdom is an abundant and still not fully explored source of diverse bioactive compounds that have since ancient times been used in the treatment of various diseases, including cancer, rheumatism, asthma and bronchitis, and many others, alleviating pain and improving blood circulation.

Extensive research is being conducted to identify new biologically active agents and to elucidate their pharmacological activities. Moreover, a new area of interest is developing very vast—the application of medicinal plant extracts to produce nanoparticles, very promising structures demonstrating antibacterial and anticancer properties.

We are interested in articles that explore the potential of plant resources for the delivery of plant-derived extracts for biomedical applications. Potential topics include but are not limited to the following:

  • The isolation of new bioactive compounds from plants;
  • The application of green synthesis approaches to obtain potent pharmacologically active agents;
  • The application of biotechnological approaches to obtain potent pharmacologically active agents;
  • Biomedical application of plant-derived compounds and extracts.

Dr. Katarzyna Sykłowska-Baranek
Dr. Łukasz Kuźma
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Plant bioactive compound
  • Biotechnology for bioactive compounds production
  • Green synthesis
  • Adaptogens
  • Antibacterial activity
  • Anticancer activity
  • Anti-inflammatory activity

Published Papers (5 papers)

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Research

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Open AccessArticle
Simultaneous Quantification of Eight Marker Components in Traditional Herbal Formula, Haepyoyijin-Tang Using HPLC–PDA
Appl. Sci. 2020, 10(11), 3888; https://doi.org/10.3390/app10113888 - 03 Jun 2020
Abstract
Haepyoyijin-tang (HPYJT) is a traditional herbal prescription that is composed of 12 medicinal herbs. Although HPYJT is frequently used in patients with asthma in Korea, no quality assessment protocols have been developed. In the present study, qualitative and quantitative analyses were performed using [...] Read more.
Haepyoyijin-tang (HPYJT) is a traditional herbal prescription that is composed of 12 medicinal herbs. Although HPYJT is frequently used in patients with asthma in Korea, no quality assessment protocols have been developed. In the present study, qualitative and quantitative analyses were performed using high-performance liquid chromatography and liquid chromatography–tandem mass spectrometry on the eight main components (mulberroside A, amygalin, liquiritin apioside, liquiritin, narirutin, hesperidin, rosmarinic acid, and glycyrrhizinic acid) to establish a quality control protocol for HPYJT. The simultaneous analysis method developed was satisfactorily validated with respect to linearity, limit of detection, limit of quantification, recovery, and precision. This analytical method thus provides an efficient approach for the evaluation of HPYJT quality. Full article
(This article belongs to the Special Issue Biomedical Application of Plant Extracts)
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Open AccessArticle
HPLC–PDA and LC–MS/MS Analysis for the Simultaneous Quantification of the 14 Marker Components in Sojadodamgangki-Tang
Appl. Sci. 2020, 10(8), 2804; https://doi.org/10.3390/app10082804 - 17 Apr 2020
Cited by 1
Abstract
Sojadodamgangki-tang (SDGT) is a traditional Korean medicine consisting of 12 medicinal herbs that has been used in Korea for the treatment of asthma since ancient times. However, the quality control of herbal formulas that contain two or more herbal medicines remains challenging. In [...] Read more.
Sojadodamgangki-tang (SDGT) is a traditional Korean medicine consisting of 12 medicinal herbs that has been used in Korea for the treatment of asthma since ancient times. However, the quality control of herbal formulas that contain two or more herbal medicines remains challenging. In this study, 14 marker components were analyzed simultaneously by using high-performance liquid chromatography with photodiode array detection in addition to the use of liquid chromatography–tandem mass spectrometry for quality evaluation of SDGT. The simultaneous determination of the 14 marker components was validated in terms of linearity, recovery, and precision. The established methods can provide useful data for the quality control of SDGT and related herbal formulas. Full article
(This article belongs to the Special Issue Biomedical Application of Plant Extracts)
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Open AccessArticle
Simultaneous Determination of 12 Marker Components in Yeonkyopaedok-san Using HPLC–PDA and LC–MS/MS
Appl. Sci. 2020, 10(5), 1713; https://doi.org/10.3390/app10051713 - 02 Mar 2020
Abstract
Yeonkyopaedok-san is a traditional Korean medicine used in the early treatment of boils. In the present study, its 12 marker components for quality control were determined using high-performance liquid chromatography (HPLC) with photodiode array detection and ultra-performance liquid chromatography–mass spectrometry with tandem mass [...] Read more.
Yeonkyopaedok-san is a traditional Korean medicine used in the early treatment of boils. In the present study, its 12 marker components for quality control were determined using high-performance liquid chromatography (HPLC) with photodiode array detection and ultra-performance liquid chromatography–mass spectrometry with tandem mass spectrometry (UPLC–MS/MS). The investigated 12 marker components of Yeonkyopaedok-san were as follows: 3-caffeoylquinic acid, cimifugin 7-glucoside, liquiritin apioside, ferulic acid, narirutin, 5-O-methylvisammioside, naringin, neohesperidin, oxypeucedanin hydrate, arctigenin, glycyrrhizic acid, and 6-gingerol. The analytical column used for the separation of the 12 marker analytes in Yeonkyopaedok-san was a Waters SunFire C18 column (4.6 mm × 250 mm, 5 μm). The two mobile phases used were 0.1% (v/v) aqueous formic acid and 0.1% (v/v) formic acid in acetonitrile. In the UPLC–MS/MS analysis, all components were separated using a Waters ACQUITY UPLC BEH C18 column (2.1 mm × 100 mm, 1.7 μm). The two mobile phases used were 0.1% (v/v) aqueous formic acid and acetonitrile. The coefficient of determination of the calibration curves in both analysis systems showed good linearity (>0.99). The amounts of the 12 marker components in Yeonkyopaedok-san determined using HPLC–photodiode array detection and UPLC–MS/MS analyses were found to be 0.14–9.00 mg/g and 2.35–853.11 μg/g, respectively. Full article
(This article belongs to the Special Issue Biomedical Application of Plant Extracts)
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Open AccessArticle
Antioxidant, Antimicrobial, Antidiabetic and Cytotoxic Activity of Crocus sativus L. Petals
Appl. Sci. 2020, 10(4), 1519; https://doi.org/10.3390/app10041519 - 23 Feb 2020
Abstract
The purpose of this research is to examine in vitro antioxidant, antimicrobial, antidiabetic and cytotoxic efficacy of different extracts of Crocus sativus L. petals. Antioxidant activity of extracts was assessed by DPPH and ABTS (2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) assay. Among all extracts, ethanol (SPE) [...] Read more.
The purpose of this research is to examine in vitro antioxidant, antimicrobial, antidiabetic and cytotoxic efficacy of different extracts of Crocus sativus L. petals. Antioxidant activity of extracts was assessed by DPPH and ABTS (2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) assay. Among all extracts, ethanol (SPE) had the maximum radical scavenging activity with IC50 values 86.63 ± 7.53 μg/mL. The antimicrobial activity was determined by the evaluation of the minimum inhibitory concentration using the agar well plate procedure. The most effective extract was SPE with a minimum inhibitory concentration varying between 500 µg/mL, 250 µg/mL, 125 µg/mL, 62.5 µg/mL, 31.25 µg/mL, 15.63 µg/mL. Cytotoxic activity was tested against MDA-MB-231 cell lines using the MTT method whereas, antidiabetic activity was evaluated using an alpha-glucosidase inhibition assay. All extracts were found to have significant antidiabetic activity. Full article
(This article belongs to the Special Issue Biomedical Application of Plant Extracts)
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Review

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Open AccessReview
Uncaria tomentosa (Willd. ex Schult.) DC.: A Review on Chemical Constituents and Biological Activities
Appl. Sci. 2020, 10(8), 2668; https://doi.org/10.3390/app10082668 - 13 Apr 2020
Abstract
Uncaria tomentosa (Willd. ex Schult.) DC. (Family: Rubiaceae), commonly known as cat’s claw, is a tropical medicinal vine originating at the Amazon rainforest and other areas of South and Central America. It has been traditionally used to treat asthma, abscesses, fever, urinary tract [...] Read more.
Uncaria tomentosa (Willd. ex Schult.) DC. (Family: Rubiaceae), commonly known as cat’s claw, is a tropical medicinal vine originating at the Amazon rainforest and other areas of South and Central America. It has been traditionally used to treat asthma, abscesses, fever, urinary tract infections, viral infections, and wounds and found to be effective as an immune system rejuvenator, antioxidant, antimicrobial, and anti-inflammatory agent. U. tomentosa is rich in many phytoconstituents such as oxindole and indole alkaloids, glycosides, organic acids, proanthocyanidins, sterols, and triterpenes. Biological activities of U. tomentosa have been examined against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium, Babesia and Theileria parasites. Several formulations of cat’s claw (e.g., tinctures, decoctions, capsules, extracts, and teas) are recently available in the market. The current review covers the chemical constituents, biological activities, pharmacokinetics, and toxic properties of U. tomentosa extracts. Full article
(This article belongs to the Special Issue Biomedical Application of Plant Extracts)
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