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Biomedical Application of Plant Extracts
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Biomedical Application of Plant Extracts

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: closed (31 July 2020) | Viewed by 42075

Special Issue Editors

Dr. Katarzyna Sykłowska-Baranek

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Guest Editor
Department of Pharmaceutical Biology and Medicinal Plants Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland
Interests: medicinal plant biotechnology; molecular biotechnology; phytochemical analysis; evaluation of plant extract biological activity
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Łukasz Kuźma

E-Mail Website
Guest Editor
Department of Biology and Pharmaceutical Botany, Chair of Biology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland
Interests: phytochemical analysis; secondary metabolites isolation; chromatographical methods; medicinal plant biotechnology, bioreactors for medicinal plant cultivation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Plant Kingdom is an abundant and still not fully explored source of diverse bioactive compounds that have since ancient times been used in the treatment of various diseases, including cancer, rheumatism, asthma and bronchitis, and many others, alleviating pain and improving blood circulation.

Extensive research is being conducted to identify new biologically active agents and to elucidate their pharmacological activities. Moreover, a new area of interest is developing very vast—the application of medicinal plant extracts to produce nanoparticles, very promising structures demonstrating antibacterial and anticancer properties.

We are interested in articles that explore the potential of plant resources for the delivery of plant-derived extracts for biomedical applications. Potential topics include but are not limited to the following:

  • The isolation of new bioactive compounds from plants;
  • The application of green synthesis approaches to obtain potent pharmacologically active agents;
  • The application of biotechnological approaches to obtain potent pharmacologically active agents;
  • Biomedical application of plant-derived compounds and extracts.

Dr. Katarzyna Sykłowska-Baranek
Dr. Łukasz Kuźma
Guest Editors

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Plant bioactive compound
  • Biotechnology for bioactive compounds production
  • Green synthesis
  • Adaptogens
  • Antibacterial activity
  • Anticancer activity
  • Anti-inflammatory activity

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Published Papers (7 papers)

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Research

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10 pages, 1906 KiB  
Article
Antioxidant Capacities of Jujube Fruit Seeds and Peel Pulp
by Yung-Sheng Lin, Wen-Shin Lin, Jing-Wen Tung, Ya-Chih Cheng, Min-Yun Chang, Cheng-You Chen and Shu-Ling Huang
Appl. Sci. 2020, 10(17), 6007; https://doi.org/10.3390/app10176007 - 30 Aug 2020
Cited by 17 | Viewed by 6295
Abstract
In this study, the effects of different fruit parts and extraction conditions on the antioxidant properties of jujube (Ziziphus jujuba Mill.) fruit were investigated. Five in vitro antioxidant models and statistical analyses were performed. The results revealed that jujube peel with pulp [...] Read more.
In this study, the effects of different fruit parts and extraction conditions on the antioxidant properties of jujube (Ziziphus jujuba Mill.) fruit were investigated. Five in vitro antioxidant models and statistical analyses were performed. The results revealed that jujube peel with pulp (peel pulp) exhibited better antioxidant capacity than did seeds. Overall, jujube peel pulp extracted using 50% ethanol at 60 °C exhibited the best antioxidant capacity in terms of 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity (0.3 ± 0 mg/mL), 2,2-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging activity (0.5 ± 0 mg/mL), total phenolic content (38.3 ± 0.4 mg gallic acid equivalent per gram dry weight), total flavonoid content (43.8 ± 0.2 mg quercetin equivalent per gram dry weight), and reducing power (41.9 ± 2.2 mg ascorbic acid equivalent per gram dry weight). The results indicated that jujube peel pulp is a more potential natural antioxidant than seeds. Full article
(This article belongs to the Special Issue Biomedical Application of Plant Extracts)
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16 pages, 3424 KiB  
Article
4-Methoxy Sulfonyl Paeonol Inhibits Hepatic Stellate Cell Activation and Liver Fibrosis by Blocking the TGF-β1/Smad, PDGF-BB/MAPK and Akt Signaling Pathways
by Yi-Jen Liao, Yuan-Hsi Wang, Chao-Lien Liu, Cheng-Chieh Fang, Ming-Hua Hsu and Fat-Moon Suk
Appl. Sci. 2020, 10(17), 5941; https://doi.org/10.3390/app10175941 - 27 Aug 2020
Cited by 2 | Viewed by 3294
Abstract
Liver fibrosis initiates the progression of cirrhosis, and, finally, hepatocellular carcinoma (HCC). The increased proliferation and activation of hepatic stellate cells (HSCs) are crucial for hepatic fibrogenesis. Paeonol is the major vigorous component of Cortex Moutan, a traditional herbal medicine widely used for [...] Read more.
Liver fibrosis initiates the progression of cirrhosis, and, finally, hepatocellular carcinoma (HCC). The increased proliferation and activation of hepatic stellate cells (HSCs) are crucial for hepatic fibrogenesis. Paeonol is the major vigorous component of Cortex Moutan, a traditional herbal medicine widely used for treating various diseases. Here, we identified a novel paeonol derivative (4-methoxy sulfonyl paeonol, 4-MSP) that inhibits TGF-β1-induced Smad2/3 phosphorylation and collagen expression in HSCs. 4-MSP pretreatment suppressed the PDGF-BB–induced phosphorylation of MAPK pathway members (MEK/ERK, p38, JNK), Akt/p70S6K, and HSC proliferation. However, 4-MSP treatment had no effect on the induction of apoptosis in HSCs. The microarray experiments showed that 4-MSP treatment affects the TGF-β signaling, MAPK cascade, and other pathways related to HSCs activation and proliferation. The administration of 4-MSP to a liver fibrosis mouse model induced by CCl4 significantly decreased the expression of hepatic fibrosis markers (α-SMA, col1A2, TGF-β, and MMP2), and attenuated hepatic collagen deposition and liver damage. In addition, no adverse effects were observed in 4-MSP exposed mice. In conclusion, this novel paeonol-phenylsulfonyl derivative prevents the progression of liver fibrosis through blocking TGF-β1/Smad, PDGF-BB/MAPK, and Akt signaling, which suggests its use as a novel therapeutic against liver fibrosis. Full article
(This article belongs to the Special Issue Biomedical Application of Plant Extracts)
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7 pages, 374 KiB  
Article
Simultaneous Quantification of Eight Marker Components in Traditional Herbal Formula, Haepyoyijin-Tang Using HPLC–PDA
by Chang-Seob Seo and Mee-Young Lee
Appl. Sci. 2020, 10(11), 3888; https://doi.org/10.3390/app10113888 - 3 Jun 2020
Cited by 7 | Viewed by 2324
Abstract
Haepyoyijin-tang (HPYJT) is a traditional herbal prescription that is composed of 12 medicinal herbs. Although HPYJT is frequently used in patients with asthma in Korea, no quality assessment protocols have been developed. In the present study, qualitative and quantitative analyses were performed using [...] Read more.
Haepyoyijin-tang (HPYJT) is a traditional herbal prescription that is composed of 12 medicinal herbs. Although HPYJT is frequently used in patients with asthma in Korea, no quality assessment protocols have been developed. In the present study, qualitative and quantitative analyses were performed using high-performance liquid chromatography and liquid chromatography–tandem mass spectrometry on the eight main components (mulberroside A, amygalin, liquiritin apioside, liquiritin, narirutin, hesperidin, rosmarinic acid, and glycyrrhizinic acid) to establish a quality control protocol for HPYJT. The simultaneous analysis method developed was satisfactorily validated with respect to linearity, limit of detection, limit of quantification, recovery, and precision. This analytical method thus provides an efficient approach for the evaluation of HPYJT quality. Full article
(This article belongs to the Special Issue Biomedical Application of Plant Extracts)
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11 pages, 655 KiB  
Article
HPLC–PDA and LC–MS/MS Analysis for the Simultaneous Quantification of the 14 Marker Components in Sojadodamgangki-Tang
by Chang-Seob Seo and Mee-Young Lee
Appl. Sci. 2020, 10(8), 2804; https://doi.org/10.3390/app10082804 - 17 Apr 2020
Cited by 7 | Viewed by 3712
Abstract
Sojadodamgangki-tang (SDGT) is a traditional Korean medicine consisting of 12 medicinal herbs that has been used in Korea for the treatment of asthma since ancient times. However, the quality control of herbal formulas that contain two or more herbal medicines remains challenging. In [...] Read more.
Sojadodamgangki-tang (SDGT) is a traditional Korean medicine consisting of 12 medicinal herbs that has been used in Korea for the treatment of asthma since ancient times. However, the quality control of herbal formulas that contain two or more herbal medicines remains challenging. In this study, 14 marker components were analyzed simultaneously by using high-performance liquid chromatography with photodiode array detection in addition to the use of liquid chromatography–tandem mass spectrometry for quality evaluation of SDGT. The simultaneous determination of the 14 marker components was validated in terms of linearity, recovery, and precision. The established methods can provide useful data for the quality control of SDGT and related herbal formulas. Full article
(This article belongs to the Special Issue Biomedical Application of Plant Extracts)
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12 pages, 949 KiB  
Article
Simultaneous Determination of 12 Marker Components in Yeonkyopaedok-san Using HPLC–PDA and LC–MS/MS
by Chang-Seob Seo and Hyeun-Kyoo Shin
Appl. Sci. 2020, 10(5), 1713; https://doi.org/10.3390/app10051713 - 2 Mar 2020
Cited by 9 | Viewed by 2970
Abstract
Yeonkyopaedok-san is a traditional Korean medicine used in the early treatment of boils. In the present study, its 12 marker components for quality control were determined using high-performance liquid chromatography (HPLC) with photodiode array detection and ultra-performance liquid chromatography–mass spectrometry with tandem mass [...] Read more.
Yeonkyopaedok-san is a traditional Korean medicine used in the early treatment of boils. In the present study, its 12 marker components for quality control were determined using high-performance liquid chromatography (HPLC) with photodiode array detection and ultra-performance liquid chromatography–mass spectrometry with tandem mass spectrometry (UPLC–MS/MS). The investigated 12 marker components of Yeonkyopaedok-san were as follows: 3-caffeoylquinic acid, cimifugin 7-glucoside, liquiritin apioside, ferulic acid, narirutin, 5-O-methylvisammioside, naringin, neohesperidin, oxypeucedanin hydrate, arctigenin, glycyrrhizic acid, and 6-gingerol. The analytical column used for the separation of the 12 marker analytes in Yeonkyopaedok-san was a Waters SunFire C18 column (4.6 mm × 250 mm, 5 μm). The two mobile phases used were 0.1% (v/v) aqueous formic acid and 0.1% (v/v) formic acid in acetonitrile. In the UPLC–MS/MS analysis, all components were separated using a Waters ACQUITY UPLC BEH C18 column (2.1 mm × 100 mm, 1.7 μm). The two mobile phases used were 0.1% (v/v) aqueous formic acid and acetonitrile. The coefficient of determination of the calibration curves in both analysis systems showed good linearity (>0.99). The amounts of the 12 marker components in Yeonkyopaedok-san determined using HPLC–photodiode array detection and UPLC–MS/MS analyses were found to be 0.14–9.00 mg/g and 2.35–853.11 μg/g, respectively. Full article
(This article belongs to the Special Issue Biomedical Application of Plant Extracts)
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12 pages, 991 KiB  
Article
Antioxidant, Antimicrobial, Antidiabetic and Cytotoxic Activity of Crocus sativus L. Petals
by Adil Farooq Wali, Houda Ahmed Abou Alchamat, Huda Khaled Hariri, Bushra Khaled Hariri, Godfred A. Menezes, Uzma Zehra, Muneeb U. Rehman and Parvaiz Ahmad
Appl. Sci. 2020, 10(4), 1519; https://doi.org/10.3390/app10041519 - 23 Feb 2020
Cited by 31 | Viewed by 4852
Abstract
The purpose of this research is to examine in vitro antioxidant, antimicrobial, antidiabetic and cytotoxic efficacy of different extracts of Crocus sativus L. petals. Antioxidant activity of extracts was assessed by DPPH and ABTS (2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) assay. Among all extracts, ethanol (SPE) [...] Read more.
The purpose of this research is to examine in vitro antioxidant, antimicrobial, antidiabetic and cytotoxic efficacy of different extracts of Crocus sativus L. petals. Antioxidant activity of extracts was assessed by DPPH and ABTS (2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) assay. Among all extracts, ethanol (SPE) had the maximum radical scavenging activity with IC50 values 86.63 ± 7.53 μg/mL. The antimicrobial activity was determined by the evaluation of the minimum inhibitory concentration using the agar well plate procedure. The most effective extract was SPE with a minimum inhibitory concentration varying between 500 µg/mL, 250 µg/mL, 125 µg/mL, 62.5 µg/mL, 31.25 µg/mL, 15.63 µg/mL. Cytotoxic activity was tested against MDA-MB-231 cell lines using the MTT method whereas, antidiabetic activity was evaluated using an alpha-glucosidase inhibition assay. All extracts were found to have significant antidiabetic activity. Full article
(This article belongs to the Special Issue Biomedical Application of Plant Extracts)
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Review

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12 pages, 1695 KiB  
Review
Uncaria tomentosa (Willd. ex Schult.) DC.: A Review on Chemical Constituents and Biological Activities
by Gaber El-Saber Batiha, Amany Magdy Beshbishy, Lamiaa Wasef, Yaser H. A. Elewa, Mohamed E. Abd El-Hack, Ayman E. Taha, Adham Abdullah Al-Sagheer, Hari Prasad Devkota and Vincenzo Tufarelli
Appl. Sci. 2020, 10(8), 2668; https://doi.org/10.3390/app10082668 - 13 Apr 2020
Cited by 42 | Viewed by 17407
Abstract
Uncaria tomentosa (Willd. ex Schult.) DC. (Family: Rubiaceae), commonly known as cat’s claw, is a tropical medicinal vine originating at the Amazon rainforest and other areas of South and Central America. It has been traditionally used to treat asthma, abscesses, fever, urinary tract [...] Read more.
Uncaria tomentosa (Willd. ex Schult.) DC. (Family: Rubiaceae), commonly known as cat’s claw, is a tropical medicinal vine originating at the Amazon rainforest and other areas of South and Central America. It has been traditionally used to treat asthma, abscesses, fever, urinary tract infections, viral infections, and wounds and found to be effective as an immune system rejuvenator, antioxidant, antimicrobial, and anti-inflammatory agent. U. tomentosa is rich in many phytoconstituents such as oxindole and indole alkaloids, glycosides, organic acids, proanthocyanidins, sterols, and triterpenes. Biological activities of U. tomentosa have been examined against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium, Babesia and Theileria parasites. Several formulations of cat’s claw (e.g., tinctures, decoctions, capsules, extracts, and teas) are recently available in the market. The current review covers the chemical constituents, biological activities, pharmacokinetics, and toxic properties of U. tomentosa extracts. Full article
(This article belongs to the Special Issue Biomedical Application of Plant Extracts)
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