Next Article in Journal
Biogas Potential of Wastes and By-Products of the Alcoholic Beverage Production Industries in the Spanish Region of Cantabria
Next Article in Special Issue
“Pull-through” Resection for Total and Subtotal Glossectomy Involving the Posterior Third of Tongue
Previous Article in Journal
Snake Robot with Driving Assistant Mechanism
Previous Article in Special Issue
Tobacco, Alcohol and Family History of Cancer as Risk Factors of Oral Squamous Cell Carcinoma: Case-Control Retrospective Study
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Applied Sciences
Volume 10
Issue 21
10.3390/app10217479
applsci-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Photo-Biomodulation as a Prevention Modality of Oral Mucositis in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

by
Ahmed Mohsen
1,
Gianluca Tenore
1,
Federica Rocchetti
1,
Alessandro Del Vecchio
1,
Roberto Ricci
2,
Walter Barberi
2,
Claudio Cartoni
2,
Anna Paola Iori
2,
Roberto Pippi
1,
Antonella Polimeni
1 and
Umberto Romeo
1,*
1
Department of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, Italy
2
Department of Cellular Biotechnologies and Hematology, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy
*
Author to whom correspondence should be addressed.
Appl. Sci. 2020, 10(21), 7479; https://doi.org/10.3390/app10217479
Submission received: 29 September 2020 / Revised: 21 October 2020 / Accepted: 22 October 2020 / Published: 24 October 2020
(This article belongs to the Special Issue Current Concept and Emerging Treatments in Oral Diseases)
Browse Figures
Versions Notes

Abstract

The aim of the study was to observe the effectiveness of a photo-biomodulation (PBM) protocol for the prevention of oral mucositis (OM) in patients undergoing allogeneic hematopoietic stem cell transplantation (aHSCT). A case-control study was conducted on 40 patients undergoing aHSCT. The patients were divided into two groups; the preventive group (PG) included 20 patients (7 females and 13 males) who were subjected to intra-oral PBM for five sessions a week, starting one day before the conditioning regimen and continuing until the 10th day after transplantation (D+10). In each session, ten points on the at-risk mucosal surfaces were irradiated using a double diode laser that emits two wavelengths simultaneously at 650 nm and at 904–910 nm with the following parameters at each point: energy of 4 J, and power of 88.9 mW. The control group (CG) included 20 patients (10 females and 10 males) who were not subjected to laser therapy and were selected retrospectively to compare the obtained results. For all patients, OM was assessed by the World Health Organization (WHO) grading scale. Eight patients in the PG did not experience OM during their hospitalization period (with grade 0). Severe OM was observed in 40% of the patients in the PG, while in the CG, severe OM was shown in 85% of the patients. The mean duration of OM in the PG was significantly lower than that of CG (4.7 days in the PG and 15 days in the CG) (p < 0.001). The study demonstrated that the preventive PBM protocol reduced the severity and duration of OM in patients undergoing aHSCT.
Keywords: allogeneic hematopoietic stem cell transplantation; chemotherapy; conditioning regimen; diode laser; oral mucositis; photo-biomodulation allogeneic hematopoietic stem cell transplantation; chemotherapy; conditioning regimen; diode laser; oral mucositis; photo-biomodulation

Share and Cite

MDPI and ACS Style

Mohsen, A.; Tenore, G.; Rocchetti, F.; Del Vecchio, A.; Ricci, R.; Barberi, W.; Cartoni, C.; Iori, A.P.; Pippi, R.; Polimeni, A.; et al. Photo-Biomodulation as a Prevention Modality of Oral Mucositis in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. Appl. Sci. 2020, 10, 7479. https://doi.org/10.3390/app10217479

AMA Style

Mohsen A, Tenore G, Rocchetti F, Del Vecchio A, Ricci R, Barberi W, Cartoni C, Iori AP, Pippi R, Polimeni A, et al. Photo-Biomodulation as a Prevention Modality of Oral Mucositis in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. Applied Sciences. 2020; 10(21):7479. https://doi.org/10.3390/app10217479

Chicago/Turabian Style

Mohsen, Ahmed, Gianluca Tenore, Federica Rocchetti, Alessandro Del Vecchio, Roberto Ricci, Walter Barberi, Claudio Cartoni, Anna Paola Iori, Roberto Pippi, Antonella Polimeni, and et al. 2020. "Photo-Biomodulation as a Prevention Modality of Oral Mucositis in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation" Applied Sciences 10, no. 21: 7479. https://doi.org/10.3390/app10217479

APA Style

Mohsen, A., Tenore, G., Rocchetti, F., Del Vecchio, A., Ricci, R., Barberi, W., Cartoni, C., Iori, A. P., Pippi, R., Polimeni, A., & Romeo, U. (2020). Photo-Biomodulation as a Prevention Modality of Oral Mucositis in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. Applied Sciences, 10(21), 7479. https://doi.org/10.3390/app10217479

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop