Table of Contents
Med. Sci., Volume 6, Issue 4 (December 2018)
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Cover Story (view full-size image) This study showed that human dermal fibroblasts produce significant levels of NO depending on [...] Read more. This study showed that human dermal fibroblasts produce significant levels of NO depending on stimulation and glucose conditions. The nitrite level in the media is not a reliable proxy for the actual level of NO produced by the cells. Using the CellNO trap, a novel measurement system developed in our lab, we are able to accurately measure NO produced by cells grown in culture without changing established culturing protocols. If we accurately measure the actual levels of NO produced by cells cultured under specific conditions, including the temporal NO release profile, we can understand and mimic the physiological NO release at different stages of wound healing and in different pathological states. This will facilitate a smooth transition of the wound from a chronic state into resolution, consequently shortening the time to complete the healing process of diabetic foot ulcers. View this paper.