- Article
CRFB5a, a Subtype of Japanese Eel (Anguilla japonica) Type I IFN Receptor, Regulates Host Antiviral and Antimicrobial Functions through Activation of IRF3/IRF7 and LEAP2
- Tianyu Wang,
- Peng Lin,
- Yilei Wang,
- Xiaojian Lai,
- Pengyun Chen,
- Fuyan Li and
- Jianjun Feng
IFNAR1, one of the type I IFN receptors, is crucial to mammalian host defense against viral invasion. However, largely unknown is the immunological role of the fish teleost protein IFNAR1, also known as CRFB5. We have successfully cloned the whole cD...

