Animals, Volume 12, Issue 21
2022 November-1 - 173 articles
Cover Story: Carnivora is an order that includes various carnivorous species, yet there is huge variation in food habitat. UDP-glucuronosyltransferases (UGTs) are important enzymes for xenobiotic metabolism or detoxification. This study was conducted to reveal the evolutional history of UGTs in Carnivorans. We found the gene expansion of UGT1As in Canidae, brown bears, and black bears, suggesting the consequences of omnivorous diet adaptation. We also found UGT2Bs duplication in Canidae, brown bears, and black bears. In addition, we discovered the contraction or complete loss of UGT1A7–12 in phocids, some otariids, felids, and some Mustelids. These studies indicate that even closely related species have completely different evolutions of UGTs and further imply the difficulty of the evaluation of pharmacokinetics in wildlife carnivorans. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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