Animals, Volume 12, Issue 13
2022 July-1 - 141 articles
Cover Story: Juvenile muskellunge are highly susceptible to the Great Lakes strain of viral hemorrhagic septicemia virus (VHSV-IVb). Experimentally infected juvenile muskellunge (Esox masquinongy) were challenged with VHSV-IVb at high, medium, and low doses. Samples of spleen, kidney, heart, liver, gills, pectoral fin, large intestine, and skin/muscle were collected at various time points. Infectious virus levels were highest in liver, heart, and skin/muscle samples. Reduced virus recovery was noted in kidney and spleen samples. Cardiac myocytes, hepatocytes, endothelium, smooth muscle cells, and pectoral fin fibroblast-like cells demonstrated riboprobe labeling by in situ hybridization overlaid in areas of necrosis and degeneration establishing the broad cellular tropism of VHSV-IVb. These results augment our understanding of VHSV-IVb pathogenesis and provide insight to alternate diagnostic samples. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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