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Volume 12
Issue 3
10.3390/microorganisms12030472
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Article

Bacterial Species Involved in Venous Leg Ulcer Infections and Their Sensitivity to Antibiotherapy—An Alarm Signal Regarding the Seriousness of Chronic Venous Insufficiency C6 Stage and Its Need for Prompt Treatment

by
Sergiu-Ciprian Matei
1,2,
Cristina Stefania Dumitru
3,*,
Ayman Mohamed Fakhry
4,
Nenad Ilijevski
5,6,
Slobodan Pešić
5,
Jovan Petrović
5,
Zorin Petrişor Crăiniceanu
7,
Marius-Sorin Murariu
1,2 and
Sorin Olariu
1,2
1
Abdominal Surgery and Phlebology Research Center, Victor Babeș University of Medicine and Pharmacy, 300041 Timisoara, Romania
2
1st Surgical Department, Pius Brînzeu Emergency County Hospital, 300736 Timisoara, Romania
3
Department of Microscopic Morphology/Histology, Angiogenesis Research Center, Victor Babeș University of Medicine and Pharmacy, 300041 Timisoara, Romania
4
Department of Vascular Surgery, Military Academy, Cairo 1000, Egypt
5
Vascular Surgery Clinic, Institute for Cardiovascular Diseases “Dedinje”, 11040 Belgrade, Serbia
6
Faculty of Medicine, University of Belgrade, 11120 Belgrade, Serbia
7
Department of Plastic and Reconstructive Surgery, Victor Babeș University of Medicine and Pharmacy, 300041 Timisoara, Romania
*
Author to whom correspondence should be addressed.
Microorganisms 2024, 12(3), 472; https://doi.org/10.3390/microorganisms12030472
Submission received: 20 January 2024 / Revised: 20 February 2024 / Accepted: 25 February 2024 / Published: 26 February 2024
(This article belongs to the Special Issue Antimicrobial Resistance: Current Status and Future Directions)
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Abstract

Background: Venous leg ulcers (VLUs) are a common chronic wound condition susceptible to infection by various bacterial species. Understanding bacterial presence and antibiotic sensitivity is crucial for effective treatment. Methodsː Medical records of 60 patients diagnosed with the C6 chronic venous insufficiency stage were analyzed retrospectively. The patients were divided into an active recurrent VLU group (33 cases) and a first-onset active VLU group (27 cases). Bacterial identification, antibiotic sensitivity, and laboratory markers were assessed. Resultsː Pseudomonas aeruginosa was the most prevalent bacterial species in both the study (72.72%) and control (37.03%) groups, along with other common bacteria such as Proteus mirabilis, Enterococcus sp., Staphylococcus aureus, Acinetobacter baumannii, Klebsiella spp., and Escherichia coli. Furthermore, uncommon bacteria, including Providencia rettgeri, Group B Streptococcus, and Salmonella Paratyphi B, and a fungal infection with Candida albicans, were identified only in the study group, while Morganella morganii was found exclusively in the control group. Pseudomonas aeruginosa showed significant sensitivity to several antibiotics, particularly Amikacin and Meropenem. Nonspecific laboratory markers, such as CRP, fibrinogen, ESR, WBC, CK, neutrophils, and lymphocytes, revealed statistically significant differences between groups, indicating their potential as biomarkers for monitoring recurrent VLUs. Conclusionsː These results highlight the need for comprehensive diagnostic approaches to effectively manage VLU infections and improve patient outcomes. Further research is warranted to explore factors influencing the presence of uncommon bacteria and to develop targeted interventions for VLU management.
Keywords: venous leg ulcer; Pseudomonas aeruginosa; bacteria; antibiotic sensitivity; chronic venous insufficiency venous leg ulcer; Pseudomonas aeruginosa; bacteria; antibiotic sensitivity; chronic venous insufficiency

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MDPI and ACS Style

Matei, S.-C.; Dumitru, C.S.; Fakhry, A.M.; Ilijevski, N.; Pešić, S.; Petrović, J.; Crăiniceanu, Z.P.; Murariu, M.-S.; Olariu, S. Bacterial Species Involved in Venous Leg Ulcer Infections and Their Sensitivity to Antibiotherapy—An Alarm Signal Regarding the Seriousness of Chronic Venous Insufficiency C6 Stage and Its Need for Prompt Treatment. Microorganisms 2024, 12, 472. https://doi.org/10.3390/microorganisms12030472

AMA Style

Matei S-C, Dumitru CS, Fakhry AM, Ilijevski N, Pešić S, Petrović J, Crăiniceanu ZP, Murariu M-S, Olariu S. Bacterial Species Involved in Venous Leg Ulcer Infections and Their Sensitivity to Antibiotherapy—An Alarm Signal Regarding the Seriousness of Chronic Venous Insufficiency C6 Stage and Its Need for Prompt Treatment. Microorganisms. 2024; 12(3):472. https://doi.org/10.3390/microorganisms12030472

Chicago/Turabian Style

Matei, Sergiu-Ciprian, Cristina Stefania Dumitru, Ayman Mohamed Fakhry, Nenad Ilijevski, Slobodan Pešić, Jovan Petrović, Zorin Petrişor Crăiniceanu, Marius-Sorin Murariu, and Sorin Olariu. 2024. "Bacterial Species Involved in Venous Leg Ulcer Infections and Their Sensitivity to Antibiotherapy—An Alarm Signal Regarding the Seriousness of Chronic Venous Insufficiency C6 Stage and Its Need for Prompt Treatment" Microorganisms 12, no. 3: 472. https://doi.org/10.3390/microorganisms12030472

APA Style

Matei, S.-C., Dumitru, C. S., Fakhry, A. M., Ilijevski, N., Pešić, S., Petrović, J., Crăiniceanu, Z. P., Murariu, M.-S., & Olariu, S. (2024). Bacterial Species Involved in Venous Leg Ulcer Infections and Their Sensitivity to Antibiotherapy—An Alarm Signal Regarding the Seriousness of Chronic Venous Insufficiency C6 Stage and Its Need for Prompt Treatment. Microorganisms, 12(3), 472. https://doi.org/10.3390/microorganisms12030472

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